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NSC 109555 ditosylate
NSC 109555 ditosylate is a selective, reversible, ATP-competitive Chk2 inhibitor that displays no effect on a range of other kinases including Chk1. Learn MoreStarting at: $119.00
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Terazosin hydrochloride
Terazosin hydrochloride is an α1- and α2B-adrenoceptor antagonist with Ki values of 3.3, 0.7, 1.1, 7.7, 1510 and 78.2 nM for α1A, α1B, α1D, α2B, α2A and α2C receptors respectively. Learn MoreStarting at: $70.00
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HPI 1
HPI 1, a Hedgehog (Hh) signaling inhibitor, inhibits Sonic hedgehog (Shh)-, SAG- and Gli-induced Hh pathway activation in Shh-LIGHT2 cells with IC50 values of 1.5, 1.5, 4 and 6 μM for Shh-, SAG-, Gli2- and Gli1-induced activation. Learn MoreStarting at: $129.00
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Citalopram hydrobromide
Citalopram hydrobromide is a highly selective and potent 5-HT uptake inhibitor with no effect on noradrenalin or dopamine uptake with IC50 values of 1.8, 8800 and 41000 nM respectively. Learn MoreStarting at: $105.00
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Paxilline
Paxilline, a potent blocker of high-conductance Ca2+-activated K+ (BKCa, KCa1.1) channels, binds to the α-subunit of BKCa (Ki = 1.9 nM for block of currents in α-subunit-expressing oocytes) and enhances binding of charybdotoxin to BKCa channels in vascular smooth muscle. Learn MoreStarting at: $198.00
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T16Ainh-A01
T16Ainh-A01 is an inhibitor of Ca2+-dependent Cl- channel (CaCC) transmembrane protein 16A (TMEM16A) (IC50 = 1.8 μM in A253 salivary gland epithelial cells). Learn MoreStarting at: $119.00
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PD 334581
PD 334581, an analog of PD 184352, is an inhibitor of MEK1. Learn MoreStarting at: $198.00
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EMD 386088 hydrochloride
EMD 386088 hydrochloride is a potent 5-HT6 receptor agonist (EC50 = 1.0 nM) that displays selectivity over other 5-HT receptors (IC50 values are 7.4, 110, 180, 240, 450, 620, 660 and 3000 nM for 5-HT6, 5-HT1D, 5-HT1B, 5-HT2A, 5-HT2C, 5-HT4, 5-HT1A and 5-HT7 receptors respectively). Learn MoreStarting at: $99.00
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Conessine
Conessine is a potent and selective histamine H3 receptor antagonist. It is a steroidal alkaloid that displays in vitro antiplasmodial activity (IC50 = 1.04 μM). Learn MoreStarting at: $92.00
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MRS 1845
MRS 1845 is potent blocker of store-operated Ca2+ channels and inhibits capacitative Ca2+ influx in HL-60 cells (IC50 = 1.7 mM). Learn MoreStarting at: $120.00
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PIT 1
PIT 1, a selective PIP3 antagonist, blocks the binding of PIP3 to the pleckstrin homology (PH) domain of Akt (IC50 = 31.03;M) and also inhibits cancer cell survival and induces apoptosis by inhibition of PIP3-dependent PI 3-kinase/Akt signaling. Learn MoreStarting at: $119.00
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(R)-DPN
(R)-DPN, a enantiomer of DPN, displays higher affinity for estrogen receptor (ER) β over ERα with Ki values of 1.82 and 147 nM respectively . Learn MoreStarting at: $186.00
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BMS 453
R-96544 hydrochloride is a potent, selective 5-HT2 receptor antagonist which displays some selectivity for 5-HT2A receptors (Ki = 1.6 nM) and inhibits 5-HT-induced platelet aggregation and pressor responses in vivo. Learn MoreStarting at: $135.00
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LY 311727
AM 630 is a CB2 antagonist/inverse agonist (Ki = 31.2 nM) that displays 165-fold selectivity over CB1 receptors. Learn MoreStarting at: $140.00
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ZK 200775
Benzamil is a Na+/Ca2+ exhanger (NCX) inhibitor (IC50 ~ 100 nM); TRPP3 channel blocker (IC50 = 1.1 μM for inhibition of Ca2+-activated TRPP3 channel activity). Learn MoreStarting at: $140.00
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SB 205384
A selective, competitive and orally active GABAB antagonist which displays an IC50 of 1.1 μM at GABAB, approximately 60 times that of CGP 35348 and no binding affinity for GABAA at concentrations up to 100 μM. Learn MoreStarting at: $135.00
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8-Hydroxy-PIPAT oxalate
SCH 58261 is a potent and selective A2A adenosine receptor competitive antagonist (Ki = 1.3 nM). Displays 323-, 53- and 100-fold selectivity over A1, A2B and A3 receptors, respectively. Learn MoreStarting at: $120.00
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L-745,870 trihydrochloride
BIBP 3226 trifluoroacetate is a mixed non-peptide neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor antagonist (Ki values are 1.1, 79, 108, > 1000, > 1000 and >1000 for rNPY Y1, hNPFF2, rNPFF, rNPY Y2, rNPY Y4 and rNPY Y5 respectively). Learn MoreStarting at: $95.00
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Terfenadine
Terfenadine is a histamine H1 receptor antagonist, which also blocks KV11.1 (hERG) and Kir6 (KATP) channels (IC50 values are 204 nM and 1.2 μM respectively). Learn MoreStarting at: $49.00
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4-Aminopyridine
4-Aminopyridine is a non-selective voltage-dependent K+-channel blocker (IC50 values are 170 and 230 μM at KV1.1 and KV1.2 respectively). Learn MoreStarting at: $55.00
