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Search results for 'inhibitor'
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Galanthamine hydrobromide
Galanthamine hydrobromide is a long-acting, centrally active acetylcholinesterase inhibitor (IC50 = 410 nM) and allosteric potentiator at neuronal nicotinic ACh receptors. Learn MoreStarting at: $75.00
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2,4-Diamino-6-hydroxypyrimidine
2,4-Diamino-6-hydroxypyrimidine is a GTP cyclohydrolase I (GCH1) inhibitor, which exhibits more potent inhibition of GCH1 in the presence of GFRP (GTP cyclohydrolase feedback-regulatory protein). Learn MoreStarting at: $69.00
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GABA
GABA is an endogenous inhibitory neurotransmitter. Learn MoreStarting at: $45.00
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Cucurbitacin I
Cucurbitacin I is a selective inhibitor of STAT3/JAK2 signaling, which inhibits the activation of STAT3 and JAK2 and displays no activity on Src, Akt, ERK and JNK. Learn MoreStarting at: $169.00
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Chicago Sky Blue 6B
Chicago Sky Blue 6B is a potent inhibitor of L-glutamate uptake into synaptic vesicles, which inhibits macrophage migration inhibitory factor (MIF) (IC50 = 0.81 μM) and MIF proinflammatory activity. Learn MoreStarting at: $49.00
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S-Trityl-L-cysteine
S-Trityl-L-cysteine is a potent, cell-permeable, selective inhibitor of mitotic kinesin Eg5, inhibits basal ATPase activity (IC50 = 1 mM) and microtubule-activated ATPase activity of Eg5 (IC50 = 140 nM). Learn MoreStarting at: $65.00
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ZM 449829
Potent is a selective inhibitor of Janus tyrosine kinase 3 (JAK3), which binds competitively to the JAK3 ATP site. And inhibits STAT-5 phosphorylation and T-cell proliferation. Learn MoreStarting at: $89.00
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SU 4312
SU 4312 is a potent and selective inhibitor of VEGFR and PDGFR tyrosine kinases (IC50 values are 0.8 and 19.4 μM respectively). Learn MoreStarting at: $189.00
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Pentoxifylline
Pentoxifylline is a phosphodiesterase inhibitor that blocks production of TNF-&alpha and other cytokines. Learn MoreStarting at: $69.00
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CPT 11
CPT 11 is an inhibitor of DNA topoisomerase I that displays antitumor activity against a range of tumor types. Learn MoreStarting at: $139.00
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TCS 2002
TCS 2002 is a potent inhibitor of GSK-3β (IC50 = 35 nM), that inhibits cold water stress-induced tau hyperphosphorylation in the mouse brain. Learn MoreStarting at: $129.00
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TC ASK 10
TC ASK 10 is a potent ASK1 inhibitor (IC50 = 14 nM) Learn MoreStarting at: $159.00
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NSC 687852
NSC 687852 is an inhibitor of 19S regulatory particle associated deubiquitylating enzymes (DUBs), UCHL5 and USP14. Learn MoreStarting at: $95.00
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PF 04691502
PF 04691502 is an potent and selective dual ATP-competitive PI 3-K/mTOR inhibitor (Ki values are 1.6, 1.8, 1.9, 2.1 and 16 nM for human PI 3-K δ, α, γ, β, and mTOR, respectively). Learn MoreStarting at: $145.00
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Olomoucine
Olomoucine is a cyclin-dependent kinase inhibitor that competes for the ATP binding site of the kinase and selectively inhibits cdc2/cyclin B (IC50 = 7 μM), cdk2/cyclin A (IC50 = 7 μM), cdk2/cyclin E (IC50 = 7 μM), cdk/p35 kinase (IC50 = 3 μM) and ERK1/MAP kinase (IC50 = 25 μM). Arrests human fibroblasts in the G1 phase. Learn MoreStarting at: $99.00
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PK 44 phosphate
PK 44 phosphate is a potent inhibitor of dipeptidyl peptidase IV (DPP-IV) (IC50 = 15.8 nM). Learn MoreStarting at: $195.00
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PSB 06126
PSB 06126 is a nucleoside triphosphate diphosphohydrolase 3 (NTPDase 3) inhibitor, which inhibits rat NTPDase 3 at low micromolar concentrations and display selectivity over NTPDase 1 and NTPDase 2. Learn MoreStarting at: $120.00
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(R)-DRF053 dihydrochloride
(R)-DRF053 dihydrochloride is a potent, ATP-competitive inhibitor of cyclin-dependent kinase (cdk) and casein kinase 1 (CK1) (IC50 values are 220, 80 and 14 nM for cdk1/cyclin B, cdk5/p25 and CK1 respectively), which also shown to inhibit amyloid-β production in N2A-APP695 cells. Learn MoreStarting at: $140.00
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ML 9 hydrochloride
ML 9 hydrochloride is a selective inhibitor of myosin light chain kinase (MLCK). Ki values are 32, 4, and 54 μM for PKA, MLCK, and PKC respectively, which inhibits STIM1-plasma membrane interactions, and preventing store-operated Ca2+ entry (SOCE). Learn MoreStarting at: $90.00
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EIT hydrobromide
EIT hydrobromide is a potent, selective and reversible inhibitor of isoform II NO synthase (IC50 = 13 nM; approximately 20- and 30-fold selective over isoforms I and III respectively). Learn MoreStarting at: $50.00
