You have no items in your shopping cart.
Search results for 'contract number'
-
SR 2640 hydrochloride
SR 2640 hydrochloride is a potent and selective competitive leukotriene D4 and E4 receptor antagonist,which Inhibits LTD4-, trachea contraction (pA2 = 8.7) and LTD4-attenuation of human PMN chemotaxis. Learn MoreStarting at: $95.00
-
Cevimeline hydrochloride
Cevimeline hydrochloride is a selective M1 receptor agonist which induces atropine-sensitive contractions of isolated guinea pig ilea and trachea preparations (EC50 values are 3.5 and 3 μM respectively). Learn MoreStarting at: $95.00
-
Amlodipine besylate
Amlodipine besylate is a L-type calcium channel blocker that displays antihypertensive properties, which inhibits Ca2+-induced contractions in depolarized rat aorta (IC50 = 1.9 nM) and displays vasoprotective effects in cardiovascular disease. Learn MoreStarting at: $50.00
-
MK 571
MK 571 is a potent CysLT1 (LTD4) leukotriene receptor inverse agonist (EC50 = 1.3 nM), which antagonizes LTD4-induced contractions of guinea pig trachea and ileum (pA2 values are 9.4 and 10.5 respectively). Learn MoreStarting at: $110.00
-
ICI 192,605
ICI 192,605 is a potent thromboxane A2 receptor (TP receptor) antagonist. Competitively inhibits contractile responses to U 46619. Learn MoreStarting at: $95.00
-
LP 12 hydrochloride
LP 12 hydrochloride is a 5-HT7 receptor agonist displaying selectivity over D2, 5-HT1A and 5-HT2A receptors (Ki values are 0.22, 7.3, 52.7 and 326 nM respectively), which induces relaxation of substance P-induced contractions in guinea pig ileum (EC50 = 1.77 μM). Learn MoreStarting at: $135.00
-
L-670,596
L-670,596 is a potent and selective thromboxane A2/prostaglandin endoperoxide receptor antagonist (IC50 = 5.5 nM), which inhibits U-44069-induced contractions of guinea pig trachea (pA2 = 9.0) and human platelet aggregation in vitro (IC50 = 6.5 nM). Learn MoreStarting at: $135.00
-
Penitrem A
Penitrem A is a potent and selective blocker of BKCa (KCa1.1) channels (IC50 values are 6.4 and 64.4 nM for BKCa channels containing α subunits only, and those containing α and β1 respectively), which blocks BKCa channels in both inside-out and cell-attached patches. Shown to enhance smooth muscle contraction in vitro and increase total peripheral resistance in vivo. Learn MoreStarting at: $75.00
-
Y-26763
Y-26763 is a kir6 (KATP) channel opener and active metabolite of Y-27152, which relaxes contracted rat aortic rings (IC50 = 0.027 mM) and inhibits glucose-induced insulin secretion in isolated human pancreatic β-cells in vitro. Learn MoreStarting at: $130.00
-
FK 888
FK 888 is a selective, high affinity tachykinin NK1 receptor antagonist (Ki = 0.69 nM) that displays 320-fold selectivity for human over rat NK1 receptors which inhibits substance P-induced contraction of isolated guinea pig trachea (IC50 = 32 nM) and inhibits substance P-induced airway constriction in vivo following i.v. and oral administration. Learn MoreStarting at: $195.00
-
BMS 182874 hydrochloride
BMS 182874 hydrochloride is a potent, selective and competitive non-peptide endothelin ETA receptor antagonist (Ki = 48 nM) which displays > 1000-fold selectivity over ETB receptors. Inhibits ET-1-induced pressor response following oral or intravenous administration in vivo and inhibits ET-1-induced longitudinal muscle contraction in the mouse colon in vitro. Learn MoreStarting at: $140.00
-
SNAP 5089
SNAP 5089 is a subtype-selective α1A-adrenoceptor antagonist that displays > 600-fold selectivity over other adrenoceptors (Kivalues are 0.35, 220, 370, 540, 800 and 1200 nM for α1A, α1B, α2C, α1D, α2B and α2A subtypes respectively and 540 nM for L-type Ca2+ channels), which inhibits noradrenalin-induced contractions in rabbit vascular and lower urinary tissues. Learn MoreStarting at: $105.00
-
GR 55562 dihydrochloride
GR 55562 dihydrochloride is a selective competitive 5-HT1B (5-HT1Dβ) silent antagonist with pKB values of 7.3 and 6.3 for human cloned 5-HT1B and 5-HT1D receptors respectively and only weak binding at a number of other 5-HT subtypes. Learn MoreStarting at: $120.00
-
KC 12291 hydrochloride
KC 12291 hydrochloride is an orally active atypical voltage-gated sodium channel blocker which inhibits sustained sodium currents (INaL) and prevents diastolic contracture in isolated atria in vitro (IC50 values are 9.6 and 0.55 - 0.79 μM respectively). Learn MoreStarting at: $135.00
-
EMD 66684
EMD 66684 is a highly potent and very selective non-peptide angiotensin AT1 receptor antagonist (IC50 values are 0.7 and > 10000 nM for AT1 and AT2 receptors respectively), which potently inhibits angiotensin II-induced contractions in isolated rabbit aorta (IC50 = 0.2 nM) and reduces blood pressure in hypertensive rats. Learn MoreStarting at: $135.00
-
Phosphocreatine disodium salt
Phosphocreatine disodium salt is a phosphate reservoir; used to regenerate ATP during skeletal muscle contraction. Learn MoreStarting at: $45.00
-
BAY 41-2272
BAY 41-2272 is an activator of soluble guanylyl cyclase (sGC)which acts at a nitric oxide (NO)-independent regulatory site in the sGC α1 subunit and inhibits platelet aggregation (IC50 = 36 nM) and phenylephrine-induced contractions of rabbit aorta (IC50 = 0.30 μM). Learn MoreStarting at: $139.00
-
Phorbol 12,13-dibutyrate
Phorbol 12,13-dibutyrate is a protein kinase C activator, which induces contraction of vascular smooth muscle and inhibits MLC phosphatase (MLCP) in vascular smooth muscle. Learn MoreStarting at: $55.00
-
FPL 55712
FPL 55712 is a leukotriene receptor antagonist which inhibits contraction of guinea pig trachealis induced by leukotrienes C4, D4, E4 and F4. Learn MoreStarting at: $149.00
-
SB 657510
SB 657510 is a selective urotensin-II (UT) receptor antagonist (Ki values are 61, 17, 30, 65 and 56 nM at human, monkey, cat, rat and mouse receptors respectively), which inhibits U-II-induced intracellular Ca2+ mobilization (IC50 = 180 nM) and antagonizes the contractile action of U-II in isolated mammalian arteries and aortae (EC50 = 50 - 189 nM). Learn MoreStarting at: $139.00
