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Search results for 'PI'
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Spironolactone
Spironolactone is a competitive mineralocorticoid (aldosterone) receptor antagonist that exhibits antihypertensive activity in vivo, displays antiandrogen activity and inhibits steroid hormone biosynthesis. Learn MoreStarting at: $45.00
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Caffeine
Caffeine is a central nervous system stimulant, which mobilizes calcium from intracellular stores and inhibits benzodiazepine binding to GABA receptors. Learn MoreStarting at: $69.00
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m-Chlorophenylbiguanide hydrochloride
m-Chlorophenylbiguanide hydrochloride is a prototypical potent and selective 5-HT3 receptor agonist. Learn MoreStarting at: $69.00
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(±)-Acetylcarnitine chloride
(±)-Acetylcarnitine chloride is weak cholinergic agonist and important intermediates in lipid metabolism. Learn MoreStarting at: $49.00
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AS 19
AS 19 is a potent 5-HT7 receptor agonist (IC50 = 0.83 nM), that enhances memory consolidation and reverses scopolamine- or dizocilpine-induced amnesia in vivo. Learn MoreStarting at: $109.00
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1-EBIO
1-EBIO is an activator of epithelial KCa channels, stimulates a large and sustained trans-epithelial Cl- secretory response across T84 monolayers. And it also induces hyperpolarization to the same magnitude as ACh in aortic value endothelial cells. Learn MoreStarting at: $65.00
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PF 04691502
PF 04691502 is an potent and selective dual ATP-competitive PI 3-K/mTOR inhibitor (Ki values are 1.6, 1.8, 1.9, 2.1 and 16 nM for human PI 3-K δ, α, γ, β, and mTOR, respectively). Learn MoreStarting at: $145.00
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Jasplakinolide
Jasplakinolide Rapidly stabilizes pre-formed actin filaments and inhibits their disassembly in vitro.It also induces polymerization of actin monomers into F-actin in vivo. Learn MoreStarting at: $205.00
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RO-3
RO-3 is a selective homomeric P2X3 and heteromeric P2X2/3 receptor antagonist (pIC50 values are 7.0 and 5.9 respectively) that exhibits no activity at P2X1, P2X2, P2X4, P2X5 and P2X7 receptors (IC50 > 10 μM). Learn MoreStarting at: $105.00
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L-655,240
L-655,240 is a potent and selective thromboxane A2/prostaglandin endoperoxide receptor antagonist. pA2 values are 8 - 8.4 in guinea pig smooth muscle; IC50 = 7 nM for inhibition of human platelet aggregation. Orally active in vivo. Learn MoreStarting at: $105.00
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Taltirelin
Taltirelin is a synthetic thyrotropin-releasing hormone (TRH) analog which displays ~ 30 - 100-fold more potent CNS activity and ~ 50-fold weaker endocrine activity than TRH. Learn MoreStarting at: $69.00
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Devazepide
Devazepide is a potent, orally active CCK1 (CCK-A) receptor antagonist that displays appetite-stimulant effects. Devazepide blocks the anorectic response to CCK-8 and increases food intake in rats following systemic and i.c.v administration. Learn MoreStarting at: $149.00
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Linopirdine dihydrochloride
Linopirdine dihydrochloride is a blocker of KV7 (KCNQ) voltage-gated potassium channels; blocks KV7.1+7.3 (KCNQ2+3) / M-currents (IC50 = 4 - 7 μM) and KV7.1 (KCNQ1) homomeric channels (IC50 = 8.9 μM). Learn MoreStarting at: $115.00
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Spiroxatrine
Spiroxatrine is a 5-HT1A antagonist, which is more active and selective than spiperone. Learn MoreStarting at: $85.00
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nor-Binaltorphimine dihydrochloride
nor-Binaltorphimine dihydrochloride is a selective κ-opioid receptor antagonist. Learn MoreStarting at: $90.00
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Cyanopindolol hemifumarate
Cyanopindolol hemifumarate is a 5-HT1A/1B antagonist with roughly equal affinity at each receptor; also a β-adrenoceptor antagonist. Learn MoreStarting at: $99.00
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Cevimeline hydrochloride
Cevimeline hydrochloride is a selective M1 receptor agonist which induces atropine-sensitive contractions of isolated guinea pig ilea and trachea preparations (EC50 values are 3.5 and 3 μM respectively). Learn MoreStarting at: $95.00
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IT1t dihydrochloride
IT1t dihydrochloride is a potent CXCR4 antagonist (IC50 = 1.1 nM in calcium mobilization assays), which blocks interaction with the HIV envelope protein, gp120 (IC50 = 7 nM, inhibition of X4-tropic HIV-1IIIB attachment). Learn MoreStarting at: $120.00
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Ch 55
Ch 55 is a highly potent synthetic retinoid that has high affinity for RAR-α and RAR-β receptors and low affinity for cellular retinoic acid binding protein (CRABP) and Inhibits rabbit tracheal epithelial cell differentiation by inhibiting transglutaminase and increasing cholesterol sulfate (EC50 values are 0.02 and 0.03 nM respectively). Learn MoreStarting at: $90.00
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BYK 204165
BYK 204165 is a potent and selective poly(ADP-ribose) polymerase (PARP)-1 inhibitor (pIC50 values are 5.38 and 7.35 for PARP-2 and PARP-1 respectively). Learn MoreStarting at: $95.00
