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Search results for 'AP 24534'
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Chicago Sky Blue 6B
Chicago Sky Blue 6B is a potent inhibitor of L-glutamate uptake into synaptic vesicles, which inhibits macrophage migration inhibitory factor (MIF) (IC50 = 0.81 μM) and MIF proinflammatory activity. Learn MoreStarting at: $49.00
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NSC 687852
NSC 687852 is an inhibitor of 19S regulatory particle associated deubiquitylating enzymes (DUBs), UCHL5 and USP14. Learn MoreStarting at: $95.00
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Phenserine
Phenserine is a Physostigmine analog that inhibits acetylcholinesterase.Phenserin also inhibits production of amyloid precursor protein (APP) and A&beta and improves morris water maze performance of scopolamine-treated rats. Learn MoreStarting at: $95.00
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Olomoucine
Olomoucine is a cyclin-dependent kinase inhibitor that competes for the ATP binding site of the kinase and selectively inhibits cdc2/cyclin B (IC50 = 7 μM), cdk2/cyclin A (IC50 = 7 μM), cdk2/cyclin E (IC50 = 7 μM), cdk/p35 kinase (IC50 = 3 μM) and ERK1/MAP kinase (IC50 = 25 μM). Arrests human fibroblasts in the G1 phase. Learn MoreStarting at: $99.00
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Jasplakinolide
Jasplakinolide Rapidly stabilizes pre-formed actin filaments and inhibits their disassembly in vitro.It also induces polymerization of actin monomers into F-actin in vivo. Learn MoreStarting at: $205.00
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Devazepide
Devazepide is a potent, orally active CCK1 (CCK-A) receptor antagonist that displays appetite-stimulant effects. Devazepide blocks the anorectic response to CCK-8 and increases food intake in rats following systemic and i.c.v administration. Learn MoreStarting at: $149.00
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Z-Cyclopentyl-AP4
Z-Cyclopentyl-AP4 is a group III mGlu receptor agonist that exhibits higher potency at mGlu4 than mGlu8 (EC50 values are 49 and 124 μM respectively) with no activity at mGlu7. And selectively inhibits synaptic activity in the lateral perforant pathway (IC50 values are 130 and 1859 μM in the lateral and medial perforant pathways respectively). Learn MoreStarting at: $129.00
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D-myo-Inositol 1,4,5-trisphosphate, hexapotassium salt
D-myo-Inositol 1,4,5-trisphosphate, hexapotassium salt, as an important second messenger involved in Ca2+ mobilization from intracellular stores (EC50 = 0.1 μM), is formed from the enzymatic hydrolysis of phosphatidyl inositol-4,5-bisphosphate. . Learn MoreStarting at: $119.00
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WEB 2086
WEB 2086 is a potent, selective platelet-activating factor (PAF) receptor antagonist (Ki = 16.3 nM). Which inhibits growth and proliferation of MCF-7 breast cancer cells. Learn MoreStarting at: $75.00
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(R)-DRF053 dihydrochloride
(R)-DRF053 dihydrochloride is a potent, ATP-competitive inhibitor of cyclin-dependent kinase (cdk) and casein kinase 1 (CK1) (IC50 values are 220, 80 and 14 nM for cdk1/cyclin B, cdk5/p25 and CK1 respectively), which also shown to inhibit amyloid-β production in N2A-APP695 cells. Learn MoreStarting at: $140.00
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nor-Binaltorphimine dihydrochloride
nor-Binaltorphimine dihydrochloride is a selective κ-opioid receptor antagonist. Learn MoreStarting at: $90.00
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Thioperamide
Thioperamide is a potent histamine H3 and H4 antagonist/inverse agonist, which blocks eosinophil shape change (IC50 = 1.4 μM) and chemotaxis (IC50 = 519 nM) induced by histamine. Learn MoreStarting at: $90.00
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EIT hydrobromide
EIT hydrobromide is a potent, selective and reversible inhibitor of isoform II NO synthase (IC50 = 13 nM; approximately 20- and 30-fold selective over isoforms I and III respectively). Learn MoreStarting at: $50.00
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SK1-I
SK1-I is a sphingosine kinase (SphK) inhibitor which inhibits the growth of both U937 and Jurkat T cells, and suppresses proliferation and induces apoptosis in several human glioblastoma cell lines. Learn MoreStarting at: $180.00
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KT 5720
KT 5720 is a potent, selective inhibitor of protein kinase A (Ki = 60 nM). Learn MoreStarting at: $165.00
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U0126
U0126 is a Potent and selective non-competitive inhibitor of MAP kinase kinase, which inhibits MEK-1 and MEK-2 (IC50 values of 0.07 and 0.06 μM respectively) with little or no effect on the activities of PKC, Abl, Raf, MEKK, ERK, JNK, MKK-3, MKK-4/SEK, MKK-6, Cdk2 or Cdk4. Learn MoreStarting at: $135.00
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Ruthenium Red
Ruthenium Red Blocks Ca2+ uptake and release from mitochondria, and Ca2+ release from ryanodine-sensitive intracellular stores. Also blocks cell membrane-located capsaicin-activated cation channels (IC50 = 14 nM) and voltage-sensitive Ca2+ channels to inhibit neurotransmitter release. Learn MoreStarting at: $65.00
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Naltrindole hydrochloride
Naltrindole hydrochloride is a highly selective non-peptide δ opioid antagonist, showing 223- and 346-fold greater activity at δ than at μ and κ opioid receptors. Learn MoreStarting at: $95.00
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Naltriben mesylate
Naltriben mesylate is a selective and potent δ-opioid receptor antagonist (Ki values are 0.013, 19 and 152 nM for δ, μ and κ receptors respectively), which displays selectivity for the δ2 subtype in vivo. Learn MoreStarting at: $100.00
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U-54494A hydrochloride
U-54494A hydrochloride is a κ-opioid agonist and anticonvulsant, which acts as an NMDA antagonist. Learn MoreStarting at: $105.00
