You have no items in your shopping cart.
Search results for '263'
-
IDE 2
IDE 2 is a cell-permeable inducer of definitive endoderm formation in mouse and human embryonic stem cells (ESCs) (EC50 = 223 nM for induction of Sox17 expression in ESCs). It has been reported to activate TGF-β signaling and downstream Smad2 phosphorylation; upregulates Nodal expression. Learn MoreStarting at: $110.00
-
Calphostin C
Calphostin C is a potent, selective and photo-dependent inhibitor of protein kinase C that targets the regulatory domain (IC50 = 50 nM). Learn MoreStarting at: $165.00
-
DL-AP4 Sodium salt
DL-AP4 Sodium salt is a sodium salt of the broad spectrum EAA ligand DL-AP4 . Learn MoreStarting at: $65.00
-
7-Chlorokynurenic acid sodium salt
7-Chlorokynurenic acid sodium salt is a sodium salt of 7-Chlorokynurenic acid, an NMDA receptor antagonist acting at the glycine site. Learn MoreStarting at: $65.00
-
PNU 142633
PNU 142633 is a very selective, high affinity 5-HT1D receptor agonist (Ki values are 6 and > 18000 nM at human 5-HT1D and 5-HT1B receptors respectively), which inhibits sympathetically-induced tachycardic responses and blocks neurogenic plasma protein extravasation in vivo. Learn MoreStarting at: $149.00
-
DL-AP3
DL-AP3 is a competitive group I metabotropic glutamate receptor antagonist and inhibitor of phosphoserine phosphatase. Learn MoreStarting at: $75.00
-
DL-AP4
DL-AP4 is a broad spectrum EAA ligand. Learn MoreStarting at: $65.00
-
PD 198306
PD 198306 is a potent inhibitor of MEK1/2, which inhibits isolated enzyme at a concentration of 8 nM and inhibits MEK activity in synovial fibroblasts at concentrations of 30 - 100 nM. Learn MoreStarting at: $189.00
-
(S)-(-)-Pindolol
(S)-(-)-Pindolol is a 5-HT1A/1Breceptor antagonist, with roughly equal affinity for each subtype. Learn MoreStarting at: $135.00
-
MS 245 oxalate
MS 245 oxalate is a high affinity 5-HT6 antagonist (Ki = 2.1 nM), which potentiates the hypolocomotor actions of (-)-nicotine in mice. Learn MoreStarting at: $139.00
-
PPT
PPT is a potent, subtype-selective estrogen receptor agonist (EC50 ~ 200 pM) which displays 410-fold selectivity for ERα over ER&beta, and prevents ovariectomy-induced weight gain and loss of bone mineral density, and induces gene expression in the hypothalamus following systemic administration in vivo. Learn MoreStarting at: $119.00
-
EMDT oxalate
EMDT oxalate is a selective 5-HT6 agonist (with a Ki value of 16 nM at human 5-HT6 receptors) which exhibits potency comparable to serotonin for the activation of adenylate cyclase, and displays antidepressant-like effects. Learn MoreStarting at: $119.00
-
AG 045572
AG 045572 is a selective gonadotropin-releasing hormone (GnRH) receptor antagonist (Ki values are 2.2, 3.8 and 6.0 nM for mouse, rat and human receptors respectively). Learn MoreStarting at: $79.00
-
S 25585
S 25585 is a potent neuropeptide Y (NPY) Y5 receptor antagonist (IC50 values are 5.4, > 1000, > 10 000 and > 10 000 nM at Y5, Y1, Y2 and Y4 receptors respectively) that displays no affinity for a wide range of other receptors. Learn MoreStarting at: $139.00
-
L-685,458
L-685,458 is a potent and selective γ-secretase inhibitor (IC50 = 17 nM) that displays > 50-fold selectivity over a range of aspartyl, serine and cysteine proteases. Learn MoreStarting at: $189.00
-
SKI II
SKI II is a selective non-lipid inhibitor of sphingosine kinase (IC50 = 0.5 μM); does not act at ATP-binding site. Learn MoreStarting at: $99.00
-
SANT-2
SANT-2 is an inhibitor of Sonic hedgehog (Shh) signaling; antagonizes smoothened receptor activity (KD = 12 nM), which displays allosteric binding characteristics similar to SANT-1. Displaces smo-[3H]SAG-1.3 and -[3H]Cyclopamine binding (Ki values are 7.8 nM and 8.4 nM respectively). Learn MoreStarting at: $139.00
-
FPR A14
FPR A14 is a formyl peptide receptor (FPR) agonist that potently activates neutrophils in vitro (EC50 values are 42 and 630 nM for neutrophil chemotaxis and Ca2+ mobilization respectively). Learn MoreStarting at: $119.00
-
Viomycin
Viomycin is a member of the tuberactinomycin family of antibiotics, which inhibits group I intron splicing and prokaryotic protein synthesis. Learn MoreStarting at: $109.00
-
TC HSD 21
TC HSD 21 is a potent 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) inhibitor (IC50 values are 6 and 40 nM at human and mouse 17β-HSD3 respectively). Learn MoreStarting at: $109.00
