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PF 04691502
PF 04691502 is an potent and selective dual ATP-competitive PI 3-K/mTOR inhibitor (Ki values are 1.6, 1.8, 1.9, 2.1 and 16 nM for human PI 3-K δ, α, γ, β, and mTOR, respectively). Learn MoreStarting at: $145.00
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MRS 2768 tetrasodium salt
MRS 2768 tetrasodium salt is a selective P2Y2 agonist (EC50 = 1.89 μM). Learn MoreStarting at: $195.00
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SER 601
SER 601 is a potent and selective CB2 receptor agonist (Ki values are 6.3 nM and 1.2 μM for CB2 and CB1 receptors respectively). Learn MoreStarting at: $109.00
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OLDA
OLDA is a potent endogenous vanilloid TRPV1 (VR1) receptor agonist (EC50 = 36 nM at hVR1) with low affinity for rCB1 receptors (Ki = 1.6 μM). Learn MoreStarting at: $75.00
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Thioperamide
Thioperamide is a potent histamine H3 and H4 antagonist/inverse agonist, which blocks eosinophil shape change (IC50 = 1.4 μM) and chemotaxis (IC50 = 519 nM) induced by histamine. Learn MoreStarting at: $90.00
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CD 1530
CD 1530 is a potent and selective RARγ receptor agonist (Ki values are 150, 1500 and 2750 nM for RARγ, RARβ and RARα receptors respectively). Activates transcriptional activity (AC50 = 1.8 nM). Learn MoreStarting at: $95.00
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MDL 11,939
MDL 11,939 is an Orally active 5-HT2A receptor antagonist, which displays selectivity for 5-HT2A receptors over 5-HT2C receptors (Ki values are 0.54, 2.5, 81.6 and ~10,000 nM at rabbit 5-HT2A, human 5-HT2A, rabbit 5-HT2C and human 5-HT2C receptors respectively). Learn MoreStarting at: $105.00
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IT1t dihydrochloride
IT1t dihydrochloride is a potent CXCR4 antagonist (IC50 = 1.1 nM in calcium mobilization assays), which blocks interaction with the HIV envelope protein, gp120 (IC50 = 7 nM, inhibition of X4-tropic HIV-1IIIB attachment). Learn MoreStarting at: $120.00
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CYM 5442 hydrochloride
CYM 5442 hydrochloride is a potent and selective S1P1 agonist in vitro (EC50 = 1.35 nM), which induces acute lymphopenia in mice. Learn MoreStarting at: $135.00
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CI 966 hydrochloride
CI 966 hydrochloride is a selective inhibitor of the GABA transporter GAT-1 (IC50 values are 0.26 and 1.2 μM at cloned human and rat GAT-1 respectively). Learn MoreStarting at: $120.00
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CGS 20625
CGS 20625 is a selective, partial agonist for the benzodiazepine binding site of the GABAA receptor which potently inhibits [3H]-flunitrazepam binding to central benzodiazepine receptors (IC50 = 1.3 nM) and displays weak affinity for peripheral benzodiazepine (IC50 = 0.68 - 2.25 μM) and GABA binding sites (IC50 > 10000 μM). Learn MoreStarting at: $135.00
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Amlodipine besylate
Amlodipine besylate is a L-type calcium channel blocker that displays antihypertensive properties, which inhibits Ca2+-induced contractions in depolarized rat aorta (IC50 = 1.9 nM) and displays vasoprotective effects in cardiovascular disease. Learn MoreStarting at: $50.00
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OctMAB
OctMAB is a dynamin inhibitor (IC50 = 1.9 μM for dynamin I) which inhibits receptor-mediated endocytosis (IC50 = 16 μM). Learn MoreStarting at: $50.00
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exo-IWR 1
exo-IWR 1 is negative control for endo-IWR 1. It also exhibits decreased activity against the Wnt/β-catenin pathway. Learn MoreStarting at: $90.00
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Dynole 34-2
Dynole 34-2 is a dynamin I inhibitor (IC50 = 1.3 μM) and inhibits receptor-mediated endocytosis (RME) (IC50 = 5.0 μM). Learn MoreStarting at: $135.00
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PPPA
PPPA is a competitive NMDA receptor antagonist that displays moderate selectivity for NR2A-containing receptors (Ki values are 0.13, 0.47, 1.10 and 3.86 μM for NR2A, NR2B, NR2C and NR2D subunits respectively). Learn MoreStarting at: $130.00
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MK 571
MK 571 is a potent CysLT1 (LTD4) leukotriene receptor inverse agonist (EC50 = 1.3 nM), which antagonizes LTD4-induced contractions of guinea pig trachea and ileum (pA2 values are 9.4 and 10.5 respectively). Learn MoreStarting at: $110.00
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VU 0238429
VU 0238429 is a selective positive allosteric modulator of M5 receptors (EC50 values are 1.16, >30 and >30 μM at M5, M1 and M3 receptors respectively), which displays no activity at M2 and M4 receptors. Learn MoreStarting at: $90.00
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Clocinnamox mesylate
Clocinnamox mesylate is a systemically active, irreversible μ-opioid receptor antagonist (apparent Ki values are 0.7, 1.9 and 5.7 nM for mouse μ, δ and κ receptors respectively). Learn MoreStarting at: $95.00
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SMANT hydrochloride
SMANT hydrochloride is an inhibitor of Smoothened (Smo) signaling via a unique mechanism, which inhibits Shh-induced accumulation of Smo::EGFP fusion protein in the primary cilium (IC50 = 1.1 μM). Learn MoreStarting at: $95.00
