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Search results for 'AP 24534'
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DCA
DCA is an inhibitor of mitochondrial pyruvate dehydrogenase kinase (PDK), which shifts pyruvate metabolism from glycolysis and lactate production to glucose oxidation in the mitochondria, and induces mitochondrial-dependent apoptosis and reverses the inhibition/downregulation of KV1.5 channels in cancer but not normal cells. Learn MoreStarting at: $55.00
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(±)-J 113397
(±)-J 113397 is a potent and selective NOP receptor antagonist (IC50 values are 2.3, 1400, 2200 and > 10000 nM for NOP, κ, μ and δ-opioid receptors respectively), which inhibits nociceptin/orphanin FQ-induced hyperalgesia in the mouse tail-flick test. Learn MoreStarting at: $189.00
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YM 58483
YM 58483 is a blocker of store-operated Ca2+ entry (SOCE), which mediates the activation of non-excitable cells (e.g. lymphocytes) and inhibits calcium release-activated calcium (CRAC) channels; suppresses thapsigargin-induced sustained Ca2+ influx (IC50 = 100 nM). Learn MoreStarting at: $145.00
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L-AP4
L-AP4 is a selective group III metabotropic glutamate receptor agonist. Synaptic depressant. Agonist at the quisqualate-sensitized AP6 site in hippocampus. Learn MoreStarting at: $60.00
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Carbetapentane citrate
Carbetapentane citrate is a selective ligand for the σ1 -site. Learn MoreStarting at: $69.00
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Dimaprit dihydrochloride
Dimaprit dihydrochloride is a selective H2 agonist with central effects upon systemic administration, which also inhibits nNOS (IC50 = 49 μM). Learn MoreStarting at: $90.00
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Probucol
Probucol is an antioxidant, anti-inflammatory and hypocholesterolemic agent, which inhibits atherogenesis in genetically hypercholesterolemic rabbits (Watanabe) and attenuates ischemia/reperfusion-induced cardiomyocyte apoptosis. Learn MoreStarting at: $59.00
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Adaphostin
Adaphostin is a p210bcr/abl tyrosine kinase inhibitor (IC50 = 14 μM), which induces apoptosis in T-lymphoblastic human leukemia cell lines (IC50 values range from 16.8 to 216.3 nM) in vitro and displays selectivity for chronic myelogenous leukemia (CML) myeloid progenitors in vitro. Learn MoreStarting at: $98.00
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CGH 2466 dihydrochloride
Adenosine A1, A2B and A3 receptor antagonist (IC50 values are 19, 21, and 80 nM respectively). Also inhibits p38 MAPK (IC50 = 187 - 400 nM) and phosphodiesterase type 4D (IC50 = 22 nM). Learn MoreStarting at: $99.00
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RWJ 56110
RWJ 56110 is a selective protease-activated receptor-1 (PAR1) antagonist which displays no activity at PAR2, PAR3, or PAR4 subtypes and blocks thrombin-induced platelet aggregation and activation of MAPK in HUVECs. Learn MoreStarting at: $119.00
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PD 180970
PD 180970 is a ATP-competitive inhibitor of p210bcr/abl tyrosine kinase; selectively induces apoptosis in chronic myeloid leukemia (CML) K562 cells, and inhibits in vivo tyrosine phosphorylation of Gab2, CrkL and p210bcr/abl (IC50 values are 80, 80 and 170 nM respectively). Learn MoreStarting at: $155.00
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Licarbazepine
Licarbazepine is an active metabolite of oxcarbazepine which produces dose-dependent inhibition of glutamatergic excitatory postsynaptic potentials (EPSPs). Learn MoreStarting at: $85.00
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Narciclasine
Narciclasine exhibits antiproliferative and pro-apoptotic effects in carcinoma cells and displays cytotoxic activity against a panel of 60 cancer cell lines (mean IC50 = 47 nM). Learn MoreStarting at: $109.00
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MNI-caged-L-glutamate
MNI-caged-L-glutamate is a MNI-caged glutamate that rapidly and efficiently releases glutamate when photolysed (300 - 380 nm excitation). Learn MoreStarting at: $139.00
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Ochratoxin A
Ochratoxin A is a mycotoxin that increases activity of the endoplasmic reticulum ATP-dependent calcium pump which induces JNK activation and apoptosis in MDCK-C7 cells at nanomolar concentrations. Learn MoreStarting at: $69.00
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Ceramide
Ceramide is a potent modulator of cell proliferation and differentiation, which activates protein phosphatase-1 (PP1) and -2A (PP2A), as well as ceramide-activated protein phosphatase (CAPP) in vitro. Learn MoreStarting at: $95.00
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UA 62784
UA 62784 is an inhibitor of microtubule polymerization in vitro, which interacts with tubulin dimers and promotes the accumulation of mammalian cells in apoptosis. Learn MoreStarting at: $139.00
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Evans Blue tetrasodium salt
Evans Blue tetrasodium salt is a potent inhibitor of L-glutamate uptake into synaptic vesicles, which inhibits AMPA and kainate receptor-mediated currents (IC50 values are 220 and 150 nM respectively). Learn MoreStarting at: $65.00
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(R)-(-)-Apomorphine hydrochloride
(R)-(-)-Apomorphine hydrochloride is a prototypical dopamine agonist (pKi values are 6.43, 7.08, 7.59, 8.36 and 7.83 for human recombinant D1, D2L, D3, D4 and D5 receptors respectively). Learn MoreStarting at: $79.00
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Imetit dihydrobromide
Imetit dihydrobromide is an extremely potent, high affinity agonist at H3 and H4 receptors (Ki values are 0.3 and 2.7 nM respectively), which induces shape change in eosinophils with an EC50 of 25 nM. Learn MoreStarting at: $90.00
