You have no items in your shopping cart.
Search results for 'AP 24534'
-
CHM 1
CHM 1 is an inducer of apoptosis; displays potent antitumor ability in human hepatocellular carcinoma which inhibits tubulin polymerization in vitro and in vivo. Causes cell cycle arrest at G2/M phase by activation of Cdc2 kinase activity. Learn MoreStarting at: $100.00
-
DIPPA hydrochloride
DIPPA hydrochloride is an irreversible and selective antagonist at the κ receptor, with persistent effect in vivo. Learn MoreStarting at: $100.00
-
SNAP 5089
SNAP 5089 is a subtype-selective α1A-adrenoceptor antagonist that displays > 600-fold selectivity over other adrenoceptors (Kivalues are 0.35, 220, 370, 540, 800 and 1200 nM for α1A, α1B, α2C, α1D, α2B and α2A subtypes respectively and 540 nM for L-type Ca2+ channels), which inhibits noradrenalin-induced contractions in rabbit vascular and lower urinary tissues. Learn MoreStarting at: $105.00
-
Donitriptan hydrochloride
Donitriptan hydrochloride is a brain penetrant 5-HT1B/1D agonist (pKi values are 9.3 and 9.4 for 5-HT1D and 5-HT1B respectively) which inhibits capsaicin-induced external carotid vasodilation and produces selective carotid vasoconstriction in various animal species. Learn MoreStarting at: $105.00
-
EGLU
EGLU is a selective antagonist of presynaptically-mediated (1S,3S)-ACPD-induced depression of motoneuron excitation in neonatal rat spinal cord; presumed group II mGlu receptor antagonist. Learn MoreStarting at: $110.00
-
FR 171113
FR 171113 is a protease-activated receptor 1 (PAR1) antagonist which exhibits potent antiplatelet activity in vitro; inhibits thrombin TRAP-6-induced platelet aggregation (IC50 = 2.5 μM). Learn MoreStarting at: $140.00
-
PPAHV
PPAHV is a non-pungent vanilloid TRPV1 (VR1) receptor agonist (Ki = 3.1 μM) that displays non-cooperative binding and induces apoptosis via a non-VR1 mechanism in Jurkat cells and causes vasoconstriction in vivo. Learn MoreStarting at: $98.00
-
TAME hydrochloride
TAME hydrochloride is a competitive inhibitor of the ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C); promotes Cdc20 autoubiquitination. Learn MoreStarting at: $39.00
-
7-Chlorokynurenic acid
7-Chlorokynurenic acid is a NMDA receptor antagonist acting at the glycine site. Potent competitive inhibitor of L-glutamate transport into synaptic vesicles. Learn MoreStarting at: $60.00
-
CPPG
CPPG is a potent group II/III mGlu receptor antagonist, with approximately 20-fold selectivity for group III over group II (IC50 values of 2.2 and 46.2 nM respectively). Learn MoreStarting at: $115.00
-
TFM-4AS-1
TFM-4AS-1 is a potent selective androgen receptor modulator (SARM) (IC50 = 30 nM), which exhibits limited effects on reproductive tissues and sebaceous glands; does not repress AP-1-sensitive MMP-1 reporter. Learn MoreStarting at: $140.00
-
C 75
C 75 is a synthetic inhibitor of fatty acid synthase (FAS) which inhibits fatty acid synthesis in vitro and in vivo and displays anorectic effects. Induces apoptosis in MCF-7 xenografts and exhibits anti-tumor activity. Learn MoreStarting at: $135.00
-
UCL 1684
UCL 1684 is a highly potent, non-peptidic blocker of the apamin-sensitive Ca2+-activated K+ channel (KCa2.1) (IC50 = 3 nM in rat sympathetic neurons) which blocks hKCa2.1 and rKCa2.2 channels expressed in HEK 293 cells with IC50 values of 762 and 364 pM respectively. Learn MoreStarting at: $119.00
-
Valinomycin
Valinomycin is a selective K+ ionophore (K0.5 values are 48, 73, 75, 93 and 246 mM for K+, Rb+, Cs+, Na+ and Li+ respectively) that transports K+ across biological and artificial lipid membranes, which inhibits Ca2+-ATPase activity and induces apoptosis through mitochondrial membrane depolarization, caspase-3 activation and phosphatidylserine translocation in vitro. Learn MoreStarting at: $50.00
-
DL-AP3
DL-AP3 is a competitive group I metabotropic glutamate receptor antagonist and inhibitor of phosphoserine phosphatase. Learn MoreStarting at: $75.00
-
DL-AP4
DL-AP4 is a broad spectrum EAA ligand. Learn MoreStarting at: $65.00
-
Ralfinamide mesylate
Ralfinamide mesylate is a sodium channel blocker, which suppresses tetrodotoxin (TTX)-resistant Na+ currents approximately twice as selectively as TTX-sensitive currents. Learn MoreStarting at: $65.00
-
NS 2028
NS 2028 is a potent soluble guanylyl cyclase (sGC) inhibitor (Ki = 8 nM), which inhibits VEGF-induced cGMP accumulation; abolishes VEGF-induced migration in postcapillary venular endothelial cells (CVEC). Learn MoreStarting at: $139.00
-
N-MPPP Hydrochloride
N-MPPP Hydrochloride is a high affinity κ agonist with no measured binding at μ or δ sites. Learn MoreStarting at: $110.00
-
5-Iodo-A-85380 dihydrochloride
5-Iodo-A-85380 dihydrochloride is a highly potent and subtype-selective agonist for the α4β2 and α6β2 nicotinic acetylcholine receptors, which activates α-CTx-MII-sensitive and -insensitive components of [3H]dopamine release from rat striatal synaptosomes, corresponding to α6β2 and α4β2 (EC50 values are 12.7 and ~35 nM respectively). ~5000- , 25000- and 140000-fold selective over α3β4, α7 and muscle nAChR receptors respectively. Learn MoreStarting at: $195.00
