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Search results for 'inhibit'
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JNJ 28871063 hydrochloride
JNJ 28871063 hydrochloride is a potent and selective ErbB receptor family inhibitor with IC50 values of 21, 22 and 38 nM for ErbB4, EGFR and ErbB2 respectively. Learn MoreStarting at: $139.00
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KC7F2
KC7F2 is an inhibitor of HIF-1α that reduces phosphorylation of eIF4E binding protein 1 (4EBP1) and p70 S6K in hypoxic conditions. Learn MoreStarting at: $69.00
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HDS 029
HDS 029 is a potent inhibitor of the ErbB receptor family that inhibits EGF-induced erbB1 autophosphorylation in NIH3T3 cells and heregulin-stimulated ErbB autophosphorylation in MDA-MB-453 human breast carcinoma cells. Learn MoreStarting at: $85.00
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OGT 2115
OGT 2115 is a heparanase inhibitor that displays no major inhibition of human cytochrome P450 isoenzymes. Learn MoreStarting at: $59.00
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HKI 357
HKI 357 is a potent, irreversible inhibitor of ErbB2 (HER2) and EGFR that suppresses ligand-induced EGFR autophosphorylation and cell proliferation in NCI-H1975 cells containing L858R and T790M mutations. Learn MoreStarting at: $189.00
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BIBU 1361 dihydrochloride
BIBU 1361 dihydrochloride is a potent inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase that inhibits growth of established human xenografts in athymic mice. Learn MoreStarting at: $85.00
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Methyl 2,5-dihydroxycinnamate
Methyl 2,5-dihydroxycinnamate is an inhibitor of EGF receptor-associated tyrosine kinases. Learn MoreStarting at: $81.00
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DMH4
DMH4 is a selective VEGFR-2 inhibitor (IC50 values are 161, 3558, 8038 and > 30000 nM for VEGFR-2, BMPR-I, AMPK and TGFβR-I respectively). Learn MoreStarting at: $140.00
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GW 583340 dihydrochloride
GW 583340 dihydrochloride is a potent dual EGFR/ErbB2 tyrosine kinase inhibitor (IC50 values are 0.01 and 0.014 μM respectively), which selectively inhibits growth of human tumor cells overexpressing EGFR and ErbB2 (IC50 values are 0.11 μM for inhibition of HN5, N87 and BT474 tumor cell lines vs. > 30 μM for inhibition of non-tumor cell line HFF). Learn MoreStarting at: $139.00
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SU 16f
SU 16f is a potent and selective platelet-derived growth factor receptor β (PDGFRβ) inhibitor (IC50 = 10 nM) that displays > 14-fold, > 229-fold and > 10000-fold selectivity over VEGFR2, FGFR1 and EGFR respectively. Learn MoreStarting at: $140.00
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PD 161570
PD 161570 is a selective FGFR inhibitor (IC50 values are 40, 262 and 3700 nM for FGFR, PDGFR and EGFR respectively), which inhibits FGFR receptor phosphorylation (IC50 = 622 nM) and growth of A121 cells in vitro. Learn MoreStarting at: $160.00
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PD 158780
PD 158780 is a potent inhibitor of ErbB receptor family tyrosine kinases (IC50 values are 0.008, 49 and 52 nM for EGFR, ErbB2 and ErbB2/ErbB4 respectively), which induces G1 cell cycle arrest in MCF10A cells and is antiproliferative in A431 human epidermal carcinoma cells. Learn MoreStarting at: $135.00
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AG 825
AG 825 is a selective ErbB2 inhibitor (IC50 values are 0.15 and 19 μM at ErbB2 and ErbB1 respectively). Learn MoreStarting at: $90.00
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Chetomin
Chetomin targets the CH1 domain of CBP/p300; inhibits interaction of HIF-1α, HIF-2α and STAT2 with CBP/p300. Attenuates hypoxia-induced gene expression in vitro and in vivo; radiosensitizes human HT 1080 fibrosarcoma cells in vitro. Learn MoreStarting at: $125.00
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DMPQ dihydrochloride
DMPQ dihydrochloride is a potent and selective inhibitor of human vascular β-type platelet derived growth factor receptor tyrosine kinase (PDGFRβ) (IC50 = 80 nM) which displays > 100-fold selectivity over EGFR tyrosine kinase, erbB2, p56, protein kinase A and protein kinase C. Learn MoreStarting at: $95.00
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ML 228
ML 228 is a HIF pathway activator (EC50 values are 1.23 and 1.4 μM for HRE gene reporter assay and HIF-1α nuclear translocation assay respectively); acts via chelation of iron, independently of PHD. Also exhibits > 80% inhibition of the human A3 receptor, dopamine transporter, μ receptor, hERG and 5-HT2B receptor, and rat sodium channel site 2, at a concentration of 10 μM. Learn MoreStarting at: $135.00
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AG 556
Epidermal growth factor receptor (EGFR) kinase inhibitor (IC50 = 1.1 μM) and selective over ErbB2 (IC50 > 500 μM). Learn MoreStarting at: $80.00
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Tyrphostin B44, (+) enantiomer
Tyrphostin B44, (+) enantiomer is an epidermal growth factor receptor (EGFR) kinase inhibitor (IC50 = 0.86 μM). Learn MoreStarting at: $105.00
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AG 494
AG 494 is a potent inhibitor of epidermal growth factor receptor (EGFR) kinase (IC50 = 0.7 μM). Learn MoreStarting at: $85.00
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AG 555
AG 555 is a potent epidermal growth factor receptor (EGFR) kinase inhibitor (IC50 = 0.7 μM) that displays 50-fold and >140-fold selectivity over ErbB2 and insulin receptor kinase respectively. Learn MoreStarting at: $80.00
