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Search results for 'as'
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RuBi-Glutamate
RuBi-Glutamate is a Ruthenium-bipyridine-triphenylphosphine caged glutamate that can be excited by visible wavelengths and releases glutamate after one- or two-photon excitation. Learn MoreStarting at: $149.00
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HDS 029
HDS 029 is a potent inhibitor of the ErbB receptor family that inhibits EGF-induced erbB1 autophosphorylation in NIH3T3 cells and heregulin-stimulated ErbB autophosphorylation in MDA-MB-453 human breast carcinoma cells. Learn MoreStarting at: $85.00
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OGT 2115
OGT 2115 is a heparanase inhibitor that displays no major inhibition of human cytochrome P450 isoenzymes. Learn MoreStarting at: $59.00
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BIBU 1361 dihydrochloride
BIBU 1361 dihydrochloride is a potent inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase that inhibits growth of established human xenografts in athymic mice. Learn MoreStarting at: $85.00
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Methyl 2,5-dihydroxycinnamate
Methyl 2,5-dihydroxycinnamate is an inhibitor of EGF receptor-associated tyrosine kinases. Learn MoreStarting at: $81.00
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GW 583340 dihydrochloride
GW 583340 dihydrochloride is a potent dual EGFR/ErbB2 tyrosine kinase inhibitor (IC50 values are 0.01 and 0.014 μM respectively), which selectively inhibits growth of human tumor cells overexpressing EGFR and ErbB2 (IC50 values are 0.11 μM for inhibition of HN5, N87 and BT474 tumor cell lines vs. > 30 μM for inhibition of non-tumor cell line HFF). Learn MoreStarting at: $139.00
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PD 158780
PD 158780 is a potent inhibitor of ErbB receptor family tyrosine kinases (IC50 values are 0.008, 49 and 52 nM for EGFR, ErbB2 and ErbB2/ErbB4 respectively), which induces G1 cell cycle arrest in MCF10A cells and is antiproliferative in A431 human epidermal carcinoma cells. Learn MoreStarting at: $135.00
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DMPQ dihydrochloride
DMPQ dihydrochloride is a potent and selective inhibitor of human vascular β-type platelet derived growth factor receptor tyrosine kinase (PDGFRβ) (IC50 = 80 nM) which displays > 100-fold selectivity over EGFR tyrosine kinase, erbB2, p56, protein kinase A and protein kinase C. Learn MoreStarting at: $95.00
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ML 228
ML 228 is a HIF pathway activator (EC50 values are 1.23 and 1.4 μM for HRE gene reporter assay and HIF-1α nuclear translocation assay respectively); acts via chelation of iron, independently of PHD. Also exhibits > 80% inhibition of the human A3 receptor, dopamine transporter, μ receptor, hERG and 5-HT2B receptor, and rat sodium channel site 2, at a concentration of 10 μM. Learn MoreStarting at: $135.00
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AG 556
Epidermal growth factor receptor (EGFR) kinase inhibitor (IC50 = 1.1 μM) and selective over ErbB2 (IC50 > 500 μM). Learn MoreStarting at: $80.00
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Tyrphostin B44, (+) enantiomer
Tyrphostin B44, (+) enantiomer is an epidermal growth factor receptor (EGFR) kinase inhibitor (IC50 = 0.86 μM). Learn MoreStarting at: $105.00
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AG 494
AG 494 is a potent inhibitor of epidermal growth factor receptor (EGFR) kinase (IC50 = 0.7 μM). Learn MoreStarting at: $85.00
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AG 555
AG 555 is a potent epidermal growth factor receptor (EGFR) kinase inhibitor (IC50 = 0.7 μM) that displays 50-fold and >140-fold selectivity over ErbB2 and insulin receptor kinase respectively. Learn MoreStarting at: $80.00
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Tyrphostin B44, (-) enantiomer
Tyrphostin B44, (-) enantiomer is a potent inhibitor of epidermal growth factor receptor (EGFR) kinase (IC50 = 0.4 μM), which is more active than the (+) enantiomer. Selective over ErbB2. Learn MoreStarting at: $75.00
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AG 490
AG 490 is a selective inhibitor of EGF receptor tyrosine kinase (IC50 values are 2 and 13.5 μM for EGFR and ErbB2 respectively). Learn MoreStarting at: $50.00
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Lavendustin A
Lavendustin A is a potent, cell-permeable inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase (IC50 = 11 nM), which inhibits p60c-src with an IC50 of 500 nM and is selective over PKA, PKC and PI 3-kinase (IC50 > 100 μM). Learn MoreStarting at: $115.00
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AG 99
AG 99 is an epidermal growth factor receptor (EGFR) kinase inhibitor (IC50 = 10 μM) that is selective over insulin receptor kinase. Learn MoreStarting at: $85.00
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AG 18
AG 18 is an inhibitor of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor (PDGFR) kinase (IC50 values are 35 and 25 μM respectively, whichi inhibits EGF-stimulated cell proliferation. Also acts as a mitochondrial uncoupler that alters phosphorylation-dependent cell signaling. Learn MoreStarting at: $80.00
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SU 4312
SU 4312 is a potent and selective inhibitor of VEGFR and PDGFR tyrosine kinases (IC50 values are 0.8 and 19.4 μM respectively). Learn MoreStarting at: $189.00
