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GGTI 297
GGTI 297 is a geranylgeranyltransferase I (GGTase-I) inhibitor (IC50 values are 135 and 418 nM for GGTase-I and FTase inhibition respectively), which inhibits RhoA prenylation leading to inactivation of RhoA/ROCK and a decrease in basal tone of the internal anal sphincter in vitro. Learn MoreStarting at: $149.00
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NPEC-caged-D-AP5
NPEC-caged-D-AP5 is a D-AP5 caged with the photosensitive 1-(2-nitrophenyl)ethoxycarbonyl (NPEC) group. NMDA receptor antagonist. Learn MoreStarting at: $189.00
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(E)-FeCP-oxindole
(E)-FeCP-oxindole is a selective inhibitor of human vascular endothelial cell growth factor receptor 2 (VEGFR-2) (IC50 = 214 nM), which displays anticancer activity (IC50< 1 μM against B16 murine melanoma lines). Learn MoreStarting at: $179.00
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RuBi-GABA
RuBi-GABA is a Ruthenium-bipyridine-triphenylphosphine caged GABA that is excited by visible wavelengths, which provides greater tissue penetration, less phototoxicity, faster photorelease kinetics and better spatial resolution than UV light-sensitive caged compounds. Learn MoreStarting at: $145.00
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Anpirtoline hydrochloride
Anpirtoline hydrochloride is a highly potent 5-HT1B receptor agonist (Ki values are 28, 150 and 1490 nM at 5-HT1B, 5-HT1A and 5-HT2 receptors respectively), which decreases central serotonin synthesis and attenuates aggressive behavior in vivo. It also acts as an antagonist at 5-HT3 receptors (Ki = 29.5 nM) and is brain penetrant. Learn MoreStarting at: $119.00
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Eltoprazine hydrochloride
Eltoprazine hydrochloride is a 5-HT1 and 5-HT2C receptor partial agonist (Ki values are 40, 52 and 81 nM for 5-HT1A, 5-HT1B and 5-HT2C receptors respectively), which reduces 5-HIAA levels in the striatum and exhibits antiaggressive behavior in vivo. Learn MoreStarting at: $99.00
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AMN 082 dihydrochloride
AMN 082 dihydrochloride is the first selective mGlu7 agonist, which potently inhibits cAMP accumulation and stimulates GTPγS binding in recombinant cells and on membranes expressing mGlu7 (EC50 = 64 - 290 nM). Learn MoreStarting at: $89.00
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Anandamide - d4
Anandamide - d4 is a deuterated anandamide that is used as an internal standard for the quantification of AEA by GC- or LC-mass spectrometry. Learn MoreStarting at: $149.00
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CYM 5541
CYM 5541 is a selective sphingosine-1-phosphate receptor 3 (S1P3) allosteric agonist that occupies a different space within the ligand binding pocket of S1P3 than S1P. Learn MoreStarting at: $115.00
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MRS 2693 trisodium salt
MRS 2693 trisodium salt is a selective P2Y6 agonist with an EC50 value of 0.015 μM at the hP2Y6 receptor. Learn MoreStarting at: $179.00
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Xaliproden hydrochloride
Xaliproden hydrochloride is an orally active, full agonist at 5-HT1A receptors that is > 300-fold selective over other 5-HT receptor subtypes with an IC50 value of > 650 nM. Learn MoreStarting at: $105.00
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VU 29
VU 29 is a potent allosteric potentiator at the rat mGlu5 receptor. Learn MoreStarting at: $139.00
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RF 9
RF 9 is a selective NPFF receptor antagonist that blocks NPFF-induced hypothermia and increases in atrial blood pressure and heart rate, and prevents opioid-induced tolerance associated with hyperalgesia in vivo. Learn MoreStarting at: $85.00
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FIT
FIT is a selective and irreversible δ-opioid agonist that acts by alkylating the receptor. Learn MoreStarting at: $139.00
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CBiPES hydrochloride
CBiPES hydrochloride is a selective positive allosteric modulator of the mGlu2 receptor with an IC50 value of 98.2 nM. Learn MoreStarting at: $115.00
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PK 11195
PK 11195 possesses high affinity for the MDR (peripheral benzodiazepine receptor) without binding to other known neurotransmitter receptors. Learn MoreStarting at: $69.00
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Lorazepam
Lorazepam is a ligand at the GABAA receptor benzodiazepine modulatory site. Learn MoreStarting at: $75.00
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Imiloxan hydrochloride
Imiloxan hydrochloride is a moderately potent, but highly selective α2-adrenoceptor antagonist, the only reported selective antagonist at the α2B-adrenoceptor not having potent α1-adrenoceptor antagonist activity. Learn MoreStarting at: $90.00
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SKF 83959 hydrobromide
SKF 83959 hydrobromide is a dopamine D1-like receptor partial agonist that act as an antagonist in vivo, producing anti-Parkinsonian effects and antagonizing the behavioral effects of cocaine. Learn MoreStarting at: $139.00
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Dihydroergotoxine mesylate
Dihydroergotoxine mesylate binds with high affinity to the GABAA receptor Cl- channel, producing an allosteric interaction with the benzodiazepine site. Learn MoreStarting at: $79.00
