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Search results for 'inhibitor'
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GGTI 297
GGTI 297 is a geranylgeranyltransferase I (GGTase-I) inhibitor (IC50 values are 135 and 418 nM for GGTase-I and FTase inhibition respectively), which inhibits RhoA prenylation leading to inactivation of RhoA/ROCK and a decrease in basal tone of the internal anal sphincter in vitro. Learn MoreStarting at: $149.00
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CHIR 99021 trihydrochloride
CHIR 99021 trihydrochloride is a hydrochloride salt of CHIR 99021, a highly selective GSK-3 inhibitor. Learn MoreStarting at: $189.00
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NU 9056
NU 9056 is a selective KAT5 (Tip60) histone acetyltransferase inhibitor (IC50 values are < 2, 60, 36, and >100 μM for KAT5, p300, pCAF and GCN5, respectively). Learn MoreStarting at: $99.00
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(E)-FeCP-oxindole
(E)-FeCP-oxindole is a selective inhibitor of human vascular endothelial cell growth factor receptor 2 (VEGFR-2) (IC50 = 214 nM), which displays anticancer activity (IC50< 1 μM against B16 murine melanoma lines). Learn MoreStarting at: $179.00
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Nefazodone hydrochloride
Nefazodone hydrochloride is a serotonin 5-HT2A receptor antagonist (Ki = 5.8 nM) and inhibitor of serotonin and noradrenalin uptake (IC50 values are 290 and 300 nM respectively). Learn MoreStarting at: $89.00
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4-Phenyl-1,2,3,4-tetrahydroisoquinoline hydrochloride
4-Phenyl-1,2,3,4-tetrahydroisoquinoline hydrochloride is an inhibitor of release of dopamine induced by methamphetamine. Learn MoreStarting at: $99.00
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Ozagrel hydrochloride
Ozagrel hydrochloride is a potent and selective inhibitor of thromboxane (TXA2) synthetase that inhibits platelet aggregation in vitro and arachidonate-induced arterial contraction in vivo. Learn MoreStarting at: $85.00
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Vigabatrin
Vigabatrin is a selective GABA-T (transaminase) inhibitor. Learn MoreStarting at: $71.00
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CGP 7930
CGP 7930 acts as a positive allosteric modulator of GABAB receptors that enhances the inhibitory effect of the agonist L-baclofen in cultured cortical neurons and increases the potency and efficacy of GABA at both native and recombinant GABAB receptors with EC50 values of 5.37 and 4.60μM respectively. Learn MoreStarting at: $89.00
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RS 39604 hydrochloride
Potent cholinesterase inhibitor, a cognition enhancer in vivo. Learn MoreStarting at: $110.00
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S-Sulfo-L-cysteine sodium salt
LY 311727 is a selective secreted phospholipase A2 (sPLA2) inhibitor (IC50 values are <1 μM for group IIA and <50 μM for group V). Learn MoreStarting at: $140.00
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(S)-3,5-DHPG
BYK 49187 is a PARP-1 and PARP-2 inhibitor (pIC50 values are 8.36 and 7.50 for cell-free recombinant PARP-1 and murine PARP-2 respectively) which displays potent inhibitory activity against human PARP-1 in cell-free and cellular assays in vitro. Learn MoreStarting at: $95.00
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Melperone hydrochloride
CDP 840 hydrochloride is a potent and selective inhibitor of phosphodiesterase (PDE) 4 (IC50 = 12 nM for native PDE4), which competitively inhibits all PDE4 isoenzymes (IC50 values are 4, 9, 9 and 45 nM for PDE4A, PDE4B, PDE4C and PDE4D human recombinant isoforms expressed in yeast). Learn MoreStarting at: $65.00
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L-371,257
RWJ 50271 is a selective inhibitor of LFA-1 (lymphocyte function-associated antigen-1) adhesion to soluble intercellular adhesion molecule (sICAM) (IC50 = 5 μM in HL60 cells). Learn MoreStarting at: $155.00
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SCH 58261
2-Iminopiperidine hydrochloride is an inhibitor of NO synthases, more potent than NG-methyl-L-arginine and selective for iNOS. Learn MoreStarting at: $135.00
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PNU 22394 hydrochloride
MPDC is a potent inhibitor of the Na+-dependent high-affinity synaptosomal glutamate transporter. Learn MoreStarting at: $95.00
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BIBP 3226 trifluoroacetate
3F8 is a potent and selective GSK-3β inhibitor (IC50 values are 34 and 304 nM in the presence of 10 and 100 μM ATP respectively). Learn MoreStarting at: $90.00
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MAP4
(S)-SNAP 5114 is a GABA transport inhibitor, showing selectivity for GAT-3 and GAT-2 (IC50 values are 5, 21 and 388 μM for hGAT-3, rGAT-2 and hGAT-1 respectively). Learn MoreStarting at: $135.00
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Gabexate mesylate
Gabexate mesylate is a serine protease inhibitor; inhibits trypsin, plasmin, plasma kallikrein and thrombin (IC50 values are 9.4, 30, 41 and 110 μM respectively).Also inhibits LPS-induced TNF-α production, probably by inhibiting NF-κB and AP-1 activation. Learn MoreStarting at: $99.00
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TACA
The trans-isomer of CACA. Potent GABAA agonist, GABA uptake inhibitor and substrate for GABA-T. Also GABAC agonist. Learn MoreStarting at: $89.00
