You have no items in your shopping cart.
Search results for 'inhibit'
-
GGTI 297
GGTI 297 is a geranylgeranyltransferase I (GGTase-I) inhibitor (IC50 values are 135 and 418 nM for GGTase-I and FTase inhibition respectively), which inhibits RhoA prenylation leading to inactivation of RhoA/ROCK and a decrease in basal tone of the internal anal sphincter in vitro. Learn MoreStarting at: $149.00
-
CHIR 99021 trihydrochloride
CHIR 99021 trihydrochloride is a hydrochloride salt of CHIR 99021, a highly selective GSK-3 inhibitor. Learn MoreStarting at: $189.00
-
NU 9056
NU 9056 is a selective KAT5 (Tip60) histone acetyltransferase inhibitor (IC50 values are < 2, 60, 36, and >100 μM for KAT5, p300, pCAF and GCN5, respectively). Learn MoreStarting at: $99.00
-
(E)-FeCP-oxindole
(E)-FeCP-oxindole is a selective inhibitor of human vascular endothelial cell growth factor receptor 2 (VEGFR-2) (IC50 = 214 nM), which displays anticancer activity (IC50< 1 μM against B16 murine melanoma lines). Learn MoreStarting at: $179.00
-
AMN 082 dihydrochloride
AMN 082 dihydrochloride is the first selective mGlu7 agonist, which potently inhibits cAMP accumulation and stimulates GTPγS binding in recombinant cells and on membranes expressing mGlu7 (EC50 = 64 - 290 nM). Learn MoreStarting at: $89.00
-
MNI 137
MNI 137 is a selective negative allosteric modulator of group II mGlu receptors with IC50 values of 8.3 and 12.6 nM for human and rat mGlu2 inhibition of glutamate-induced calcium mobilization. Learn MoreStarting at: $139.00
-
(R)-(+)-m-Nitrobiphenyline oxalate
(R)-(+)-m-Nitrobiphenyline oxalate is a α2C-adrenoceptor agonist that potently inhibits cAMP accumulation in CHO cells with an EC50 value of 38 nM. Learn MoreStarting at: $149.00
-
MJ 15
MJ 15 is a potent and selective CB1 receptor antagonist that inhibits food intake and increases in body weight in diet-induced obese rats and mice. Learn MoreStarting at: $139.00
-
(±)-Clopidogrel hydrochloride
(±)-Clopidogrel hydrochloride is a selective, high affinity P2Y12 receptor antagonist that inhibits ADP-induced platelet aggregation. Learn MoreStarting at: $99.00
-
G-1
G-1 is a potent and selective GPR30 receptor agonist that increases cytosolic Ca2+ and inhibits migration of SKBr3 cells and MCF-7 cells in response to chemoattractants with IC50 values of 0.7 and 1.6 nM respectively in vitro. Learn MoreStarting at: $139.00
-
MEDICA 16
MEDICA 16 is a free fatty acid 1 (FFA1/GPR40) receptor agonist that reduces intracellular triacylglycerol levels in muscle and inhibits lipogenesis and increases insulin sensitivity in rodents in vivo. Learn MoreStarting at: $115.00
-
JNJ 10191584 maleate
JNJ 10191584 maleate is a highly selective histamine H4 receptor silent antagonist that inhibits mast cell and eosinophil chemotaxis in vitro with IC50 values of 138 and 530 nM respectively. Learn MoreStarting at: $99.00
-
C 021 dihydrochloride
C 021 dihydrochloride is a potent CCR4 chemokine receptor antagonist with IC50 values of 0.14 and 0.039 μM for inhibition of chemotaxis in human and mouse respectively. Learn MoreStarting at: $149.00
-
PF 514273
PF 514273 is a potent and selective CB1 receptor antagonist that inhibits food intake in vivo following oral administration. Learn MoreStarting at: $139.00
-
CID 16020046
CID 16020046 is a selective GPR55 antagonist that inhibits LPI-induced Ca2+ signaling with an IC50 value of 0.21 μM in HEK-GPR55 cells. Learn MoreStarting at: $139.00
-
Nefazodone hydrochloride
Nefazodone hydrochloride is a serotonin 5-HT2A receptor antagonist (Ki = 5.8 nM) and inhibitor of serotonin and noradrenalin uptake (IC50 values are 290 and 300 nM respectively). Learn MoreStarting at: $89.00
-
Cabergoline
Cabergoline is a selective D2-like dopamine receptor agonist that inhibits secretion of prolactin and growth hormone and reverses levodopa-induced dyskinesias in Parkinsonian monkeys. Learn MoreStarting at: $149.00
-
Alfuzosin hydrochloride
Alfuzosin hydrochloride is a uro-selective α1 adrenoceptor antagonist that inhibits increases in intraurethral pressure caused by phenylephrine-induced contraction by 81% with minor cardiovascular effects. Learn MoreStarting at: $69.00
-
Iloprost
Iloprost is a prostacyclin (PGI2) analog that inhibits platelet aggregation induced by collagen, thrombin and ADP with IC50 values of 0.24, 0.71 and 1.07 nM respectively. Learn MoreStarting at: $239.00
-
CDPPB
CDPPB is a brain penetrant, selective positive allosteric modulator at the mGlu5 receptor with reverses amphetamine-induced locomotor activity and amphetamine-induced deficits in prepulse inhibition in rats. Learn MoreStarting at: $119.00
