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Search results for 'as'
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GGTI 297
GGTI 297 is a geranylgeranyltransferase I (GGTase-I) inhibitor (IC50 values are 135 and 418 nM for GGTase-I and FTase inhibition respectively), which inhibits RhoA prenylation leading to inactivation of RhoA/ROCK and a decrease in basal tone of the internal anal sphincter in vitro. Learn MoreStarting at: $149.00
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NU 9056
NU 9056 is a selective KAT5 (Tip60) histone acetyltransferase inhibitor (IC50 values are < 2, 60, 36, and >100 μM for KAT5, p300, pCAF and GCN5, respectively). Learn MoreStarting at: $99.00
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(E)-FeCP-oxindole
(E)-FeCP-oxindole is a selective inhibitor of human vascular endothelial cell growth factor receptor 2 (VEGFR-2) (IC50 = 214 nM), which displays anticancer activity (IC50< 1 μM against B16 murine melanoma lines). Learn MoreStarting at: $179.00
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RuBi-GABA
RuBi-GABA is a Ruthenium-bipyridine-triphenylphosphine caged GABA that is excited by visible wavelengths, which provides greater tissue penetration, less phototoxicity, faster photorelease kinetics and better spatial resolution than UV light-sensitive caged compounds. Learn MoreStarting at: $145.00
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Anpirtoline hydrochloride
Anpirtoline hydrochloride is a highly potent 5-HT1B receptor agonist (Ki values are 28, 150 and 1490 nM at 5-HT1B, 5-HT1A and 5-HT2 receptors respectively), which decreases central serotonin synthesis and attenuates aggressive behavior in vivo. It also acts as an antagonist at 5-HT3 receptors (Ki = 29.5 nM) and is brain penetrant. Learn MoreStarting at: $119.00
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(+)-UH 232 maleate
(+)-UH 232 maleate is a D2 antagonist (Ki = 72.7 nM in a ligand binding assay; apparent KB = 14.5 nM in a cAMP accumulation assay), which displays preferential activity at central dopamine autoreceptors. Learn MoreStarting at: $109.00
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Anandamide - d4
Anandamide - d4 is a deuterated anandamide that is used as an internal standard for the quantification of AEA by GC- or LC-mass spectrometry. Learn MoreStarting at: $149.00
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AA 29504
AA 29504 is a positive allosteric modulator of GABAA receptors that modulates both α4β3δ-containing extrasynaptic receptors and α1β3γ2S-containing receptors in Xenopus oocytes. Learn MoreStarting at: $139.00
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MJ 15
MJ 15 is a potent and selective CB1 receptor antagonist that inhibits food intake and increases in body weight in diet-induced obese rats and mice. Learn MoreStarting at: $139.00
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Ro 15-4513
Ro 15-4513 is a high affinity benzodiazepine ligand that acts as partial inverse agonist at recombinant DS α1-, α2-, α3- and α5-GABAA receptors. Learn MoreStarting at: $115.00
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AC 55541
AC 55541 is a potent and selective protease-activated receptor 2 (PAR2) agonist that stimulates cell proliferation, PI hydrolysis and Ca2+ mobilization in vitro and exhibits pronociceptive activity in vivo. Learn MoreStarting at: $149.00
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BAY 60-6583
BAY 60-6583 is a potent adenosine A2B receptor agonist that decreases fMLP-induced superoxide production in neutrophils at low concentrations (1-10 nM). Learn MoreStarting at: $139.00
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G-1
G-1 is a potent and selective GPR30 receptor agonist that increases cytosolic Ca2+ and inhibits migration of SKBr3 cells and MCF-7 cells in response to chemoattractants with IC50 values of 0.7 and 1.6 nM respectively in vitro. Learn MoreStarting at: $139.00
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LY 171883
LY 171883 is a selective, orally active leukotriene D4 (LTD4) antagonist and also acts as an agonist at peroxisome proliferator-activated receptors (PPARs). Learn MoreStarting at: $75.00
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ML 221
ML 221 is an apelin receptor (APJ) antagonist with IC50 values of 0.70 and 1.75 μM in a cAMP assay and β-arrestin assay, respectively). Learn MoreStarting at: $139.00
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RF 9
RF 9 is a selective NPFF receptor antagonist that blocks NPFF-induced hypothermia and increases in atrial blood pressure and heart rate, and prevents opioid-induced tolerance associated with hyperalgesia in vivo. Learn MoreStarting at: $85.00
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MEDICA 16
MEDICA 16 is a free fatty acid 1 (FFA1/GPR40) receptor agonist that reduces intracellular triacylglycerol levels in muscle and inhibits lipogenesis and increases insulin sensitivity in rodents in vivo. Learn MoreStarting at: $115.00
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WAY 207024 dihydrochloride
WAY 207024 dihydrochloride is a gonadotropin releasing hormone receptor (GnRH-R) antagonist that exhibits potent affinity with IC50 values of 12 and 71 nM for human and rat GnRH receptors respectively. Learn MoreStarting at: $189.00
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JNJ 10191584 maleate
JNJ 10191584 maleate is a highly selective histamine H4 receptor silent antagonist that inhibits mast cell and eosinophil chemotaxis in vitro with IC50 values of 138 and 530 nM respectively. Learn MoreStarting at: $99.00
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PF9 tetrasodium salt
PF9 tetrasodium salt is a potent agonist of GPR17 with an EC50 value of 36 pM. Learn MoreStarting at: $195.00
