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Search results for 'PR 171'
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GGTI 297
GGTI 297 is a geranylgeranyltransferase I (GGTase-I) inhibitor (IC50 values are 135 and 418 nM for GGTase-I and FTase inhibition respectively), which inhibits RhoA prenylation leading to inactivation of RhoA/ROCK and a decrease in basal tone of the internal anal sphincter in vitro. Learn MoreStarting at: $149.00
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Anti-PIKFyve
Anti-PIKFyve is an antibody raised against recombinant protein corresponding to amino acid residues 1083-1200 of human PIKfyve . Learn MoreStarting at: $299.00
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RuBi-GABA
RuBi-GABA is a Ruthenium-bipyridine-triphenylphosphine caged GABA that is excited by visible wavelengths, which provides greater tissue penetration, less phototoxicity, faster photorelease kinetics and better spatial resolution than UV light-sensitive caged compounds. Learn MoreStarting at: $145.00
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Eltoprazine hydrochloride
Eltoprazine hydrochloride is a 5-HT1 and 5-HT2C receptor partial agonist (Ki values are 40, 52 and 81 nM for 5-HT1A, 5-HT1B and 5-HT2C receptors respectively), which reduces 5-HIAA levels in the striatum and exhibits antiaggressive behavior in vivo. Learn MoreStarting at: $99.00
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Eticlopride hydrochloride
Eticlopride hydrochloride is a selective dopamine D2/D3 receptor antagonist (Ki values are 0.50 and 0.16 nM respectively). Learn MoreStarting at: $99.00
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AMN 082 dihydrochloride
AMN 082 dihydrochloride is the first selective mGlu7 agonist, which potently inhibits cAMP accumulation and stimulates GTPγS binding in recombinant cells and on membranes expressing mGlu7 (EC50 = 64 - 290 nM). Learn MoreStarting at: $89.00
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(+)-UH 232 maleate
(+)-UH 232 maleate is a D2 antagonist (Ki = 72.7 nM in a ligand binding assay; apparent KB = 14.5 nM in a cAMP accumulation assay), which displays preferential activity at central dopamine autoreceptors. Learn MoreStarting at: $109.00
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DPNI-Caged GABA
DPNI-Caged GABA is a nitroindoline-caged GABA with similar photochemical properties to MNI-glutamate. Learn MoreStarting at: $335.00
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AC 55541
AC 55541 is a potent and selective protease-activated receptor 2 (PAR2) agonist that stimulates cell proliferation, PI hydrolysis and Ca2+ mobilization in vitro and exhibits pronociceptive activity in vivo. Learn MoreStarting at: $149.00
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TCB-2
TCB-2 is a high affinity 5-HT2A receptor agonist that potently stimulates IP3 accumulation in NIH3T3 cells stably expressing rat 5-HT2A receptors with an EC50 value of 36 nM. Learn MoreStarting at: $139.00
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BAY 60-6583
BAY 60-6583 is a potent adenosine A2B receptor agonist that decreases fMLP-induced superoxide production in neutrophils at low concentrations (1-10 nM). Learn MoreStarting at: $139.00
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Xaliproden hydrochloride
Xaliproden hydrochloride is an orally active, full agonist at 5-HT1A receptors that is > 300-fold selective over other 5-HT receptor subtypes with an IC50 value of > 650 nM. Learn MoreStarting at: $105.00
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G-1
G-1 is a potent and selective GPR30 receptor agonist that increases cytosolic Ca2+ and inhibits migration of SKBr3 cells and MCF-7 cells in response to chemoattractants with IC50 values of 0.7 and 1.6 nM respectively in vitro. Learn MoreStarting at: $139.00
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LY 171883
LY 171883 is a selective, orally active leukotriene D4 (LTD4) antagonist and also acts as an agonist at peroxisome proliferator-activated receptors (PPARs). Learn MoreStarting at: $75.00
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RF 9
RF 9 is a selective NPFF receptor antagonist that blocks NPFF-induced hypothermia and increases in atrial blood pressure and heart rate, and prevents opioid-induced tolerance associated with hyperalgesia in vivo. Learn MoreStarting at: $85.00
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MEDICA 16
MEDICA 16 is a free fatty acid 1 (FFA1/GPR40) receptor agonist that reduces intracellular triacylglycerol levels in muscle and inhibits lipogenesis and increases insulin sensitivity in rodents in vivo. Learn MoreStarting at: $115.00
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SKF 86466 hydrochloride
SKF 86466 hydrochloride is a potent and selective α2 antagonist at pre- and post-junctional α2-adrenoceptors that exhibits antihypertensive activity in a rat model. Learn MoreStarting at: $115.00
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1,3-Dipropyl-8-phenylxanthine
1,3-Dipropyl-8-phenylxanthine is a selective A1 adenosine antagonist. Learn MoreStarting at: $95.00
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(+)-AJ 76 hydrochloride
(+)-AJ 76 hydrochloride is a dopamine receptor antagonist with preferential action at presynaptic receptors. Learn MoreStarting at: $115.00
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PF9 tetrasodium salt
PF9 tetrasodium salt is a potent agonist of GPR17 with an EC50 value of 36 pM. Learn MoreStarting at: $195.00
