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Search results for 'Glutamate'
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MNI 137
MNI 137 is a selective negative allosteric modulator of group II mGlu receptors with IC50 values of 8.3 and 12.6 nM for human and rat mGlu2 inhibition of glutamate-induced calcium mobilization. Learn MoreStarting at: $139.00
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DPNI-Caged GABA
DPNI-Caged GABA is a nitroindoline-caged GABA with similar photochemical properties to MNI-glutamate. Learn MoreStarting at: $335.00
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VU 1545
VU 1545 is a metabotropic glutamate receptor 5 (mGlu5) positive allosteric modulator. Learn MoreStarting at: $115.00
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(S)-3-Hydroxyphenylglycine
(S)-3-Hydroxyphenylglycine is an agonist at group I metabotropic glutamate receptors (mGlu1) having no effect at mGlu2 or mGlu4. Learn MoreStarting at: $169.00
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DCB
DCB is an allosteric ligand for the metabotropic glutamate receptor mGlu5 that displays neutral modulation. Learn MoreStarting at: $70.00
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(±)-trans-ACPD
(±)-trans-ACPD, equimolecular mixture of (1S,3R)- and (1R,3S)-ACPD, is a selective agonist for metabotropic glutamate receptors. Learn MoreStarting at: $139.00
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MSOP
MSOP is a selective group III metabotropic glutamate receptor antagonist that displays an apparent KDof 51 μM for the L-AP4-sensitive presynaptic mGluR on primary afferent terminals in spinal cord compared to > 700 μM for the (1S,3S)-ACPD-sensitive presynaptic mGlu in the same system. Learn MoreStarting at: $138.00
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L-Glutamic acid
L-Glutamic is the predominant excitatory transmitter in the mammalian central nervous system. It acts at ionotropic and metabotropic glutamate receptors. Learn MoreStarting at: $32.00
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(S)-3-Carboxy-4-hydroxyphenylglycine
(S)-3-Carboxy-4-hydroxyphenylglycine is a mixed group I metabotropic glutamate receptor antagonist and group II mGlu agonist. Learn MoreStarting at: $269.00
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3-MATIDA
3-MATIDA is a potent metabotropic glutamate mGlu1 receptor antagonist with IC50 = 6.3 μM at rat mGlu1a. Learn MoreStarting at: $140.00
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E4CPG
(RS)-APICA is a rigidified analog of MPPG; selective group II metabotropic glutamate receptor antagonist (IC50 = 30 μM) with no significant effect on group I and III mGlu receptors at concentrations up to 1 mM. Learn MoreStarting at: $95.00
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CHPG
E4CPG is a novel group I/group II metabotropic glutamate receptor antagonist, more potent than (RS)-MCPG. Learn MoreStarting at: $80.00
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MPPG
MTPG is a group II/group III metabotropic glutamate receptor antagonist, showing selectivity for group II in electrophysiological studies. Learn MoreStarting at: $135.00
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RS 67506 hydrochloride
(2R,4R)-APDC is a highly selective and relatively potent group II metabotropic glutamate receptor agonist. EC50 values are 0.4, 0.4, > 100, > 100, > 300 and > 300 μM for human mGlu2, mGlu3, mGlu1, mGlu5, mGlu4 and mGlu7 receptors respectively. Learn MoreStarting at: $90.00
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BW 723C86 hydrochloride
DMP 543 is a K+ channel blocker and acetylcholine release stimulator, which potently enhances K+-stimulated [3H]-ACh release from rat hippocampal slices (EC50 = 700 nM), and also increases release of dopamine and glutamate (EC50 values are 0.25 and 0.22 μM, respectively). Learn MoreStarting at: $95.00
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PNU 22394 hydrochloride
MPDC is a potent inhibitor of the Na+-dependent high-affinity synaptosomal glutamate transporter. Learn MoreStarting at: $95.00
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L-755,507
L-BMAA hydrochloride is a neurotoxic glutamate agonist originally isolated from Cycas circinalis. Learn MoreStarting at: $115.00
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JNJ 16259685
JNJ 16259685 is a sub-nanomolar potent, non-competitive mGlu1 antagonist (Ki = 0.34 nM), which inhibits glutamate-induced Ca2+ response at the human mGlu1 receptor with an IC50 value of 0.55 nM. Learn MoreStarting at: $169.00
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O-Phospho-L-serine
O-Phospho-L-serine is a group III metabotropic glutamate receptor agonist; analog of L-AP4, which inhibits proliferation and enhances neuronal differentiation in progenitor cells. Learn MoreStarting at: $59.00
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DMeOB
DMeOB is a negative allosteric modulator of the metabotropic glutamate receptor mGlu5 which displays reversible non-competitive inhibition of mGlu5-mediated responses (IC50 = 3 μM). Learn MoreStarting at: $79.00
