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Search results for '263'
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AS 1269574
AS 1269574 is a GPR119 receptor agonist (EC50 = 2.5 μM in HEK293 cells expressing human GPR119), which enhances insulin secretion stimulated by glucose in vivo. Stimulates proglucagon gene promoter actvity. Learn MoreStarting at: $119.00
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MRT 10
MRT 10 is a smoothened (Smo) receptor antagonist (IC50 = 0.5 μM in HEK293 cells transiently expressing mouse Smo), which inhibits ShhN-induced Gli luciferase reporter activity in Shh-light2 cells (IC50 = 2.5 μM); acts as an inverse agonist during nontranscriptional hedgehog pathway activation (IC50 = 2.5 μM in HEK293 cells). Learn MoreStarting at: $119.00
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FPR A14
FPR A14 is a formyl peptide receptor (FPR) agonist that potently activates neutrophils in vitro (EC50 values are 42 and 630 nM for neutrophil chemotaxis and Ca2+ mobilization respectively). Learn MoreStarting at: $119.00
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S 25585
S 25585 is a potent neuropeptide Y (NPY) Y5 receptor antagonist (IC50 values are 5.4, > 1000, > 10 000 and > 10 000 nM at Y5, Y1, Y2 and Y4 receptors respectively) that displays no affinity for a wide range of other receptors. Learn MoreStarting at: $139.00
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AG 045572
AG 045572 is a selective gonadotropin-releasing hormone (GnRH) receptor antagonist (Ki values are 2.2, 3.8 and 6.0 nM for mouse, rat and human receptors respectively). Learn MoreStarting at: $79.00
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EMDT oxalate
EMDT oxalate is a selective 5-HT6 agonist (with a Ki value of 16 nM at human 5-HT6 receptors) which exhibits potency comparable to serotonin for the activation of adenylate cyclase, and displays antidepressant-like effects. Learn MoreStarting at: $119.00
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MS 245 oxalate
MS 245 oxalate is a high affinity 5-HT6 antagonist (Ki = 2.1 nM), which potentiates the hypolocomotor actions of (-)-nicotine in mice. Learn MoreStarting at: $139.00
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(S)-(-)-Pindolol
(S)-(-)-Pindolol is a 5-HT1A/1Breceptor antagonist, with roughly equal affinity for each subtype. Learn MoreStarting at: $135.00
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DL-AP3
DL-AP3 is a competitive group I metabotropic glutamate receptor antagonist and inhibitor of phosphoserine phosphatase. Learn MoreStarting at: $75.00
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PNU 142633
PNU 142633 is a very selective, high affinity 5-HT1D receptor agonist (Ki values are 6 and > 18000 nM at human 5-HT1D and 5-HT1B receptors respectively), which inhibits sympathetically-induced tachycardic responses and blocks neurogenic plasma protein extravasation in vivo. Learn MoreStarting at: $149.00
