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Search results for 'AP 24534'
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RWJ 56110
RWJ 56110 is a selective protease-activated receptor-1 (PAR1) antagonist which displays no activity at PAR2, PAR3, or PAR4 subtypes and blocks thrombin-induced platelet aggregation and activation of MAPK in HUVECs. Learn MoreStarting at: $119.00
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CGH 2466 dihydrochloride
Adenosine A1, A2B and A3 receptor antagonist (IC50 values are 19, 21, and 80 nM respectively). Also inhibits p38 MAPK (IC50 = 187 - 400 nM) and phosphodiesterase type 4D (IC50 = 22 nM). Learn MoreStarting at: $99.00
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Dimaprit dihydrochloride
Dimaprit dihydrochloride is a selective H2 agonist with central effects upon systemic administration, which also inhibits nNOS (IC50 = 49 μM). Learn MoreStarting at: $90.00
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L-AP4
L-AP4 is a selective group III metabotropic glutamate receptor agonist. Synaptic depressant. Agonist at the quisqualate-sensitized AP6 site in hippocampus. Learn MoreStarting at: $60.00
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(±)-J 113397
(±)-J 113397 is a potent and selective NOP receptor antagonist (IC50 values are 2.3, 1400, 2200 and > 10000 nM for NOP, κ, μ and δ-opioid receptors respectively), which inhibits nociceptin/orphanin FQ-induced hyperalgesia in the mouse tail-flick test. Learn MoreStarting at: $189.00
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N-MPPP Hydrochloride
N-MPPP Hydrochloride is a high affinity κ agonist with no measured binding at μ or δ sites. Learn MoreStarting at: $110.00
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DL-AP3
DL-AP3 is a competitive group I metabotropic glutamate receptor antagonist and inhibitor of phosphoserine phosphatase. Learn MoreStarting at: $75.00
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CPPG
CPPG is a potent group II/III mGlu receptor antagonist, with approximately 20-fold selectivity for group III over group II (IC50 values of 2.2 and 46.2 nM respectively). Learn MoreStarting at: $115.00
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FR 171113
FR 171113 is a protease-activated receptor 1 (PAR1) antagonist which exhibits potent antiplatelet activity in vitro; inhibits thrombin TRAP-6-induced platelet aggregation (IC50 = 2.5 μM). Learn MoreStarting at: $140.00
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EGLU
EGLU is a selective antagonist of presynaptically-mediated (1S,3S)-ACPD-induced depression of motoneuron excitation in neonatal rat spinal cord; presumed group II mGlu receptor antagonist. Learn MoreStarting at: $110.00
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Donitriptan hydrochloride
Donitriptan hydrochloride is a brain penetrant 5-HT1B/1D agonist (pKi values are 9.3 and 9.4 for 5-HT1D and 5-HT1B respectively) which inhibits capsaicin-induced external carotid vasodilation and produces selective carotid vasoconstriction in various animal species. Learn MoreStarting at: $105.00
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SNAP 5089
SNAP 5089 is a subtype-selective α1A-adrenoceptor antagonist that displays > 600-fold selectivity over other adrenoceptors (Kivalues are 0.35, 220, 370, 540, 800 and 1200 nM for α1A, α1B, α2C, α1D, α2B and α2A subtypes respectively and 540 nM for L-type Ca2+ channels), which inhibits noradrenalin-induced contractions in rabbit vascular and lower urinary tissues. Learn MoreStarting at: $105.00
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DIPPA hydrochloride
DIPPA hydrochloride is an irreversible and selective antagonist at the κ receptor, with persistent effect in vivo. Learn MoreStarting at: $100.00
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SR 49059
SR 49059 is a potent and selective non-peptide vasopressin V1A receptor antagonist; devoid of agonist activity, which displays high affinity and efficacy at both rat (Ki = 1.6 nM) and human (Ki = 1.1 - 6.3 nM) V1A receptors. Learn MoreStarting at: $225.00
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DEA
DEA is a potent endocannabinoid and anandamide analog that activates CB1 receptors in microglia and binds to rat synaptosomal membranes (Ki = 34.4 nM). Learn MoreStarting at: $80.00
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ML 10302 hydrochloride
ML 10302 hydrochloride is a potent 5-HT4 partial agonist (EC50 = 4 nM) that displays > 680-fold selectivity over 5-HT3 receptors (Ki values are 1.07 and 730 nM respectively). Increases sAPPα levels in the cortex in an animal model of Alzheimer's disease and exhibits progastrokinetic effects in vivo. Learn MoreStarting at: $80.00
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SB 205607 dihydrobromide
SB 205607 dihydrobromide is the first described non-peptide δ1 opioid receptor agonist with very high affinity and selectivity for the δ1 subtype (Ki values are 1.12, 2320 and 1790 nM at δ1, μ and κ receptors respectively). Learn MoreStarting at: $175.00
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DCG IV
DCG IV is a presynaptic depressant; highly potent agonist for group II mGlu receptors. Learn MoreStarting at: $135.00
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Clobenpropit dihydrobromide
Clobenpropit dihydrobromide is an extremely potent histamine H3 antagonist/inverse agonist (pA2=9.93), which displays partial agonist activity at H4 receptors; induces eosinophil shape change with an EC50 of 3 nM. Learn MoreStarting at: $115.00
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Diprenorphine
Diprenorphine is a non-selective opioid receptor antagonist (Ki values are 0.017, 0.072 and 0.23 nM for κ-, μ- and δ-opioid receptors). Learn MoreStarting at: $125.00
