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Search results for 'AP 24534'
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Buprenorphine hydrochloride
Buprenorphine hydrochloride, an ORL1 receptor agonist, displays mixed antagonist/partial agonist activity at κ, δ and μ-opioid receptors. Learn MoreStarting at: $40.00
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D-Amphetamine sulfate
D-Amphetamine sulfate,a CNS stimulant, targets monoamine transporters to elevate synaptic levels of noradrenalin, dopamine and serotonin. Learn MoreStarting at: $50.00
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(RS)-APICA
PNU 96415E is antipsychotic agent which displays high affinity for dopamine D4 and serotonergic 5-HT2A receptors and relatively weak affinity at D2 receptors (Ki values are 3.0, 5.8, 134, 181, 199, 240, 411 and > 678 nM for D4, 5-HT2A, 5-HT1A, α1, D2, D3, D1, α2 and muscarinic receptors respectively). Learn MoreStarting at: $105.00
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E4CPG
(RS)-APICA is a rigidified analog of MPPG; selective group II metabotropic glutamate receptor antagonist (IC50 = 30 μM) with no significant effect on group I and III mGlu receptors at concentrations up to 1 mM. Learn MoreStarting at: $95.00
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MSPG
MPPG is a potent antagonist of L-AP4-induced effects in rat spinal cord, thalamic and hippocampal neurons, showing selectivity over (1S,3S)-ACPD-induced effects. Potent antagonist of mGlu receptors linked to adenylyl cyclase in adult rat cortical slices. Learn MoreStarting at: $135.00
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(2R,4R)-APDC
MSPG is a selatively non-selective antagonist of presynaptic mGlu receptors in neonatal rat spinal cord and adult rat cerebrocortical mGlu receptors. Learn MoreStarting at: $165.00
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RS 67506 hydrochloride
(2R,4R)-APDC is a highly selective and relatively potent group II metabotropic glutamate receptor agonist. EC50 values are 0.4, 0.4, > 100, > 100, > 300 and > 300 μM for human mGlu2, mGlu3, mGlu1, mGlu5, mGlu4 and mGlu7 receptors respectively. Learn MoreStarting at: $90.00
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SB 205384
A selective, competitive and orally active GABAB antagonist which displays an IC50 of 1.1 μM at GABAB, approximately 60 times that of CGP 35348 and no binding affinity for GABAA at concentrations up to 100 μM. Learn MoreStarting at: $135.00
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PNU 22394 hydrochloride
MPDC is a potent inhibitor of the Na+-dependent high-affinity synaptosomal glutamate transporter. Learn MoreStarting at: $95.00
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MAP4
(S)-SNAP 5114 is a GABA transport inhibitor, showing selectivity for GAT-3 and GAT-2 (IC50 values are 5, 21 and 388 μM for hGAT-3, rGAT-2 and hGAT-1 respectively). Learn MoreStarting at: $135.00
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SNAP 94847 hydrochloride
SNAP 94847 hydrochloride is a potent melanin-concentrating hormone receptor 1 (MCH1) antagonist (Ki = 2.2 nM, KD = 530 pM) that displays > 80-fold and > 500-fold selectivity over α1A and D2 receptors respectively. Learn MoreStarting at: $149.00
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DOI hydrochloride
Brain penetrant, mixed 5-HT2A/5-HT2C receptor agonist (Ki values are 0.7, 2.4 and 20 nM for 5-HT2A, 5-HT2C and 5-HT2B receptors respectively), which reduces rapid eye movement (REM) and slow wave sleep and increases waking in the rat. Learn MoreStarting at: $90.00
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O-Phospho-L-serine
O-Phospho-L-serine is a group III metabotropic glutamate receptor agonist; analog of L-AP4, which inhibits proliferation and enhances neuronal differentiation in progenitor cells. Learn MoreStarting at: $59.00
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Gabexate mesylate
Gabexate mesylate is a serine protease inhibitor; inhibits trypsin, plasmin, plasma kallikrein and thrombin (IC50 values are 9.4, 30, 41 and 110 μM respectively).Also inhibits LPS-induced TNF-α production, probably by inhibiting NF-κB and AP-1 activation. Learn MoreStarting at: $99.00
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Zaprinast
Zaprinast is a phosphodiesterase inhibitor, selective for PDE6, 5, 11 and 9 (IC50 values are 0.15, 0.76, 12.0 and 29.0 μM respectively). Learn MoreStarting at: $65.00
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GNTI dihydrochloride
GNTI dihydrochloride is a highly potent κ opioid receptor antagonist (Ki = 0.18 nM for human cloned κ receptors expressed in CHO cells), which displays 208- and 799-fold selectivity over μ and δ receptors respectively. Learn MoreStarting at: $139.00
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SDM25N hydrochloride
SDM25N hydrochloride is a potent and highly selective non-peptide δ receptor antagonist (Ki values are 4.7, 3800 and 7900 nM for δ, κ and μ receptors respectively). Learn MoreStarting at: $125.00
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UBP1112
UBP1112 is a selective group III mGlu receptor antagonist (apparent Kd values are 5.1 and 488 μM for group III and group II mGlu receptors respectively; IC50 > 1 mM for group I, NMDA, AMPA and kainate receptors). Learn MoreStarting at: $139.00
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Imetit dihydrobromide
Imetit dihydrobromide is an extremely potent, high affinity agonist at H3 and H4 receptors (Ki values are 0.3 and 2.7 nM respectively), which induces shape change in eosinophils with an EC50 of 25 nM. Learn MoreStarting at: $90.00
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(R)-(-)-Apomorphine hydrochloride
(R)-(-)-Apomorphine hydrochloride is a prototypical dopamine agonist (pKi values are 6.43, 7.08, 7.59, 8.36 and 7.83 for human recombinant D1, D2L, D3, D4 and D5 receptors respectively). Learn MoreStarting at: $79.00
