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RuBi-Dopa
RuBi-Dopa is a RuBi-caged dopamine; exhibits two-photon sensitivity, and enables non-invasive, optical activation of dopamine receptors with the spatial resolution of a single dendritic spine. Learn MoreStarting at: $199.00
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MIM1
MIM1 is an inhibitor of Mcl-1, which selectively targets the BH3-binding pocket. Induces caspase-3/7 activation and cell death in Mcl-1-dependent leukemia cells. Learn MoreStarting at: $125.00
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±-AMG 487
±-AMG 487 is an antagonist of CXCR3; inhibits binding of 125I-IP-10 and 125I-ITAC to CXCR3 (IC50 values are 8.0 and 8.2 nM respectively), which inhibits CXCR3-mediated cell migration by the chemokines IP-10, ITAC and MiG in vitro (IC50 values are 8, 15 and 36 nM respectively). Learn MoreStarting at: $189.00
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(Z)-FeCP-oxindole
(Z)-FeCP-oxindole is a selective inhibitor of human vascular endothelial cell growth factor receptor 2 (VEGFR-2) (IC50 = 220 nM), which displays anticancer activity (IC50< 1 μM against B16 murine melanoma lines). Learn MoreStarting at: $179.00
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PF 750
PF 750 is an irreversible fatty acid amide hydrolase (FAAH) inhibitor that displays no activity at a range of other serine hydrolases. Learn MoreStarting at: $149.00
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SID 26681509
SID 26681509 is a potent and reversible human cathepsin L inhibitor with an IC50 value of 56 nM. Learn MoreStarting at: $149.00
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GPi 688
GPi 688 is an allosteric glycogen phosphorylase inhibitor that inhibits glucagon-mediated hyperglycemia in vivo in the rat. Learn MoreStarting at: $179.00
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PPY A
PPY A is a potent inhibitor of T315l mutant and wild-type Abl kinases that inhibits growth of cells transformed with either the Bcr-Abl T315l mutant or wild-type Bcr-Abl gene. Learn MoreStarting at: $169.00
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Ro 3306
Ro 3306 is an ATP-competitive, potent cyclin-dependent kinase (cdk) 1 inhibitor that downregulates the expression of antiapoptotic proteins such as Bcl-2 and survivin and enhances downstream p53 signaling in acute myeloid leukemia (AML). Learn MoreStarting at: $139.00
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AMG 548
AMG 548 is a potent and selective inhibitor of p38α (Ki values are 0.5, 3.6, 2600 and 4100 nM for p38α, p38β, p38γ and p38δ respectively). Displays >1000-fold selectivity against 36 other kinases; inhibits whole blood LPS-stimulated TNFα (IC50 = 3 nM). Efficacious in acute and chronic models of arthritis. Learn MoreStarting at: $189.00
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PF 915275
PF 915275 is a potent and selective 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) inhibitor that inhibits the conversion of prednisone to prednisolone in human hepatocytes in vitro and has antidiabetic activity in vivo. Learn MoreStarting at: $115.00
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(R)-(-)-Rolipram
(R)-(-)-Rolipram is an enantiomer of the PDE4 inhibitor rolipram that is 2-10-fold more potent than the S-(+) enantiomer. Learn MoreStarting at: $139.00
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TCS 2312
TCS 2312 is a potent and selective checkpoint kinase 1 (chk1) inhibitor that enhances the cell killing activity of Gemcitabine in breast and prostate cancer cell lines and displays antiproliferative effects in vitro. Learn MoreStarting at: $139.00
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RHC 80267
RHC 80267 is an inhibitor of diacylglycerol lipase that potentiates acetylcholine evoked relaxation in mesenteric arteries by the inhibition of cholinesterase activity. Learn MoreStarting at: $99.00
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Moexipril hydrochloride
Moexipril hydrochloride is an angiotensin-converting enzyme (ACE) inhibitor that decreases mean blood pressure in the spontaneous hypertensive rat (SHR) and also blocks degradation of bradykinin into inactive metabolites. Learn MoreStarting at: $109.00
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Cilastatin sodium
Cilastatin sodium is a dipeptidase inhibitor that inhibits metabolism of LTD4 to LTE4 and the hydrolysis of β-lactam antibiotics. Learn MoreStarting at: $89.00
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Edelfosine
Edelfosine is a synthetic lysophospholipid analog that selectively inhibits phosphatidylinositol phospholipase C. Learn MoreStarting at: $89.00
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Oncrasin 1
Oncrasin 1 is a proapoptotic agent that exhibits antiproliferative effects against various human tumor cell lines with K-Ras mutations (IC50 ≤ 3 μM) with minimal effects on normal epithelial cells and inhibits human xenograft growth by 75% in vivo. Learn MoreStarting at: $105.00
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p-Chlorophenylalanine
p-Chlorophenylalanine binds irreversibly to tryptophan hydroxylase to cause depletion of serotonin in the brain. Learn MoreStarting at: $55.00
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ZJ 43
ZJ 43 is a potent inhibitor of glutamate carboxypeptidase II and III (GCP II and III/NAAG peptidase/NAALADase) that inhibits the hydrolysis of NAAG (IC50 = 2.4 nM). Learn MoreStarting at: $89.00
