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Search results for 'PR 171'
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CRT 0066101
CRT 0066101 is a potent inhibitor of protein kinase D (PKD), which inhibits all PKD isoforms (IC50 values are 1, 2 and 2.5 nM for PKD1, PKD3 and PKD2 respectively). Learn MoreStarting at: $199.00
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MDL 72527
MDL 72527 is a polyamine oxidase (POA) inhibitor that displays anticancer and neuroprotective activity in vivo. Learn MoreStarting at: $109.00
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FPA 124
FPA 124 is an Akt/PKB inhibitor that inhibits cell proliferation in various cancer cell lines in vitro and decreases NF-κB activity and tumor load in vivo. Learn MoreStarting at: $125.00
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TCS JNK 6o
TCS JNK 6o is an ATP-competitive c-Jun N-terminal kinase (JNK) inhibitor that inhibits c-Jun phosphorylation (EC50 = 920 nM) and prevents collagen-induced platelet aggregation in vitro. Learn MoreStarting at: $149.00
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KU 0060648
KU 0060648 is a dual, ATP-competitive inhibitor of DNA-dependent protein kinase (DNA-PK) and PI 3-K. Learn MoreStarting at: $195.00
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Ro 3306
Ro 3306 is an ATP-competitive, potent cyclin-dependent kinase (cdk) 1 inhibitor that downregulates the expression of antiapoptotic proteins such as Bcl-2 and survivin and enhances downstream p53 signaling in acute myeloid leukemia (AML). Learn MoreStarting at: $139.00
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DPPI 1c hydrochloride
DPPI 1c hydrochloride is an inhibitor of dipeptidyl peptidase IV (DPP-IV) that increases plasma GLP-1 levels and improves glucose tolerance in diabetic mice following oral glucose challenge. Learn MoreStarting at: $85.00
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K-252c
K-252c is an inhibitor of protein kinase C that exhibits antiviral activity against GCV-sensitive and -resistant strains of human cytomegalovirus (HCMV). Learn MoreStarting at: $99.00
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PF 915275
PF 915275 is a potent and selective 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) inhibitor that inhibits the conversion of prednisone to prednisolone in human hepatocytes in vitro and has antidiabetic activity in vivo. Learn MoreStarting at: $115.00
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(R)-(-)-Rolipram
(R)-(-)-Rolipram is an enantiomer of the PDE4 inhibitor rolipram that is 2-10-fold more potent than the S-(+) enantiomer. Learn MoreStarting at: $139.00
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Irsogladine maleate
Irsogladine maleate is a phosphodiesterase 4 (PDE4) inhibitor that prevents gastric mucosal injury induced by monochloramine and ischemia-reperfusion. Learn MoreStarting at: $99.00
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H-7 dihydrochloride
H-7 dihydrochloride is a protein kinase inhibitor. Learn MoreStarting at: $95.00
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C-1
C-1 is an inhibitor of protein kinase C. Learn MoreStarting at: $105.00
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H-9 dihydrochloride
H-9 dihydrochloride is a protein kinase inhibitor that inhibits PKA, PKG, CaMK II, PKC, casein kinase I and casein kinase II. Learn MoreStarting at: $89.00
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TCS 2312
TCS 2312 is a potent and selective checkpoint kinase 1 (chk1) inhibitor that enhances the cell killing activity of Gemcitabine in breast and prostate cancer cell lines and displays antiproliferative effects in vitro. Learn MoreStarting at: $139.00
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Nafamostat mesylate
Nafamostat mesylate is a broad spectrum serine protease inhibitor that reduces eosinophil infiltration, mast cell activation and airway responsiveness in a murine model of asthma. Learn MoreStarting at: $45.00
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CI 898 trihydrochloride
CI 898 trihydrochloride is a potent lipophilic inhibitor of dihydrofolate reductase (DHFR) that inhibits protozoal, bacterial and human DHFR with IC50 values of 1.4, 6.1 and 3.2 nM respectively. Learn MoreStarting at: $139.00
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Moexipril hydrochloride
Moexipril hydrochloride is an angiotensin-converting enzyme (ACE) inhibitor that decreases mean blood pressure in the spontaneous hypertensive rat (SHR) and also blocks degradation of bradykinin into inactive metabolites. Learn MoreStarting at: $109.00
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10Z-Hymenialdisine
10Z-Hymenialdisine is a pan kinase inhibitor that inhibits NF-κB activation and blocks IL-8 production in U937 cells with IC50 values of 1-2 and 0.34-0.48 μM respectively. Learn MoreStarting at: $259.00
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Oncrasin 1
Oncrasin 1 is a proapoptotic agent that exhibits antiproliferative effects against various human tumor cell lines with K-Ras mutations (IC50 ≤ 3 μM) with minimal effects on normal epithelial cells and inhibits human xenograft growth by 75% in vivo. Learn MoreStarting at: $105.00
