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Search results for 'PI'
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RuBi-Dopa
RuBi-Dopa is a RuBi-caged dopamine; exhibits two-photon sensitivity, and enables non-invasive, optical activation of dopamine receptors with the spatial resolution of a single dendritic spine. Learn MoreStarting at: $199.00
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PI 828
PI 828 is a PI 3-Kinase inhibitor with IC50 values of 0.098, 0.183, 0.227 and 1.967 μM for p110β, p110α, p110δ and p110γ respectively. Learn MoreStarting at: $69.00
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GPi 688
GPi 688 is an allosteric glycogen phosphorylase inhibitor that inhibits glucagon-mediated hyperglycemia in vivo in the rat. Learn MoreStarting at: $179.00
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KU 0060648
KU 0060648 is a dual, ATP-competitive inhibitor of DNA-dependent protein kinase (DNA-PK) and PI 3-K. Learn MoreStarting at: $195.00
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SC 66
SC 66 is an allosteric inhibitor of Akt that interferes with pleckstrin homology domain binding to PIP3 and facilitates Akt ubiquitination. Learn MoreStarting at: $75.00
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DPPI 1c hydrochloride
DPPI 1c hydrochloride is an inhibitor of dipeptidyl peptidase IV (DPP-IV) that increases plasma GLP-1 levels and improves glucose tolerance in diabetic mice following oral glucose challenge. Learn MoreStarting at: $85.00
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Edelfosine
Edelfosine is a synthetic lysophospholipid analog that selectively inhibits phosphatidylinositol phospholipase C. Learn MoreStarting at: $89.00
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Oncrasin 1
Oncrasin 1 is a proapoptotic agent that exhibits antiproliferative effects against various human tumor cell lines with K-Ras mutations (IC50 ≤ 3 μM) with minimal effects on normal epithelial cells and inhibits human xenograft growth by 75% in vivo. Learn MoreStarting at: $105.00
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PIR 3.5
PIR 3.5 is a non-competitive inhibitor of group I p21-activated kinase (Pak1). Learn MoreStarting at: $92.00
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PIT 1
PIT 1, a selective PIP3 antagonist, blocks the binding of PIP3 to the pleckstrin homology (PH) domain of Akt (IC50 = 31.03;M) and also inhibits cancer cell survival and induces apoptosis by inhibition of PIP3-dependent PI 3-kinase/Akt signaling. Learn MoreStarting at: $119.00
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Tris DBA
Tris DBA is a N-myristoyltransferase-1 (NMT-1) inhibitor that prevents activation of MAPK, PI 3-K and STAT3 signaling pathways. Learn MoreStarting at: $75.00
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Ambenonium dichloride
Ambenonium dichloride is a extremely potent, selective and rapidly reversible inhibitor of acetylcholinesterase (AChE) with IC50 values =0.000698 and 8.20 μM at AChE and BChE respectively. Learn MoreStarting at: $99.00
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SC 236
CHPG is a selective mGlu5 metabotropic glutamate receptor agonist, completely inactive at mGlu1a receptors expressed in CHO cells. Learn MoreStarting at: $110.00
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Tacrine hydrochloride
AIDA is a relatively potent and selective antagonist of group I metabotropic glutamate receptors (mGlu1a), having no effect on group II (mGlu2) or group III (mGlu4) receptors expressed individually in baby hamster kidney cells. Learn MoreStarting at: $60.00
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Phorbol 12-myristate 13-acetate
Naltrexone hydrochloride is an opioid antagonist. Learn MoreStarting at: $50.00
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Indirubin-3'-oxime
ARL 67156 trisodium salt is a selective ecto-ATPase inhibitor (pIC50 = 4.62 and 5.1 in human blood and rat vas deferens respectively). Learn MoreStarting at: $110.00
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2-Iminopiperidine hydrochloride
SR 11302 is an inhibitor of activator protein-1 (AP-1) transcription factor activity that displays antitumor effects in vivo. Learn MoreStarting at: $70.00
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API-1
API-1 is an Akt/protein kinase B (PKB) inhibitor, which binds the pleckstrin homology domain of Akt and blocks Akt membrane translocation, and inhibits EGF-induced kinase activity of Akt1, AKT2 and AKT3. Activity results in cell growth arrest and apoptosis in human cancer cells with constitutively active Akt. Learn MoreStarting at: $229.00
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BPIPP
BPIPP is a non-competitive guanylyl cyclase (GC) and adenylyl cyclase (AC) inhibitor, which downregulates cAMP and cGMP synthesis, and suppresses cGMP accumulation in a variety of cell lines (IC50 = 3.4 - 11.2 μM). It also inhibits GC-stimulated Cl- transport in vitro and suppresses toxin-induced intestinal fluid accumulation in vivo. Learn MoreStarting at: $145.00
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SKI II
SKI II is a selective non-lipid inhibitor of sphingosine kinase (IC50 = 0.5 μM); does not act at ATP-binding site. Learn MoreStarting at: $99.00
