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Search results for 'LY 215840'
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CRT 0066101
CRT 0066101 is a potent inhibitor of protein kinase D (PKD), which inhibits all PKD isoforms (IC50 values are 1, 2 and 2.5 nM for PKD1, PKD3 and PKD2 respectively). Learn MoreStarting at: $199.00
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PF 04885614
PF 04885614 is a potent NaV1.8 inhibitor (IC50 = 53 nM for human NaV1.8 channel), which exhibits selectivity for hNaV1.8 over hNaV1.6, hNaV1.7, hNaV1.1, hNaV1.2 and hNaV1.5 (IC50 values are 4.2, 7.0, 11, 16 and 27 μM respectively). Learn MoreStarting at: $125.00
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SGC-CBP30
SGC-CBP30 is a potent CREBBP/EP300 bromodomain inhibitor (IC50 values are 21-69 and 38 nM for CREBBP and EP300 bromodomains respectively), which displays over 40-fold selectivity for CREBBP over BRD4(1). Learn MoreStarting at: $199.00
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MIM1
MIM1 is an inhibitor of Mcl-1, which selectively targets the BH3-binding pocket. Induces caspase-3/7 activation and cell death in Mcl-1-dependent leukemia cells. Learn MoreStarting at: $125.00
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±-AMG 487
±-AMG 487 is an antagonist of CXCR3; inhibits binding of 125I-IP-10 and 125I-ITAC to CXCR3 (IC50 values are 8.0 and 8.2 nM respectively), which inhibits CXCR3-mediated cell migration by the chemokines IP-10, ITAC and MiG in vitro (IC50 values are 8, 15 and 36 nM respectively). Learn MoreStarting at: $189.00
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PHA 767491 hydrochloride
PHA 767491 hydrochloride is a potent, ATP-competitive dual cdc7/cdk9 inhibitor with IC50 valuesof 10 and 34 nM respectively. Learn MoreStarting at: $99.00
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PI 828
PI 828 is a PI 3-Kinase inhibitor with IC50 values of 0.098, 0.183, 0.227 and 1.967 μM for p110β, p110α, p110δ and p110γ respectively. Learn MoreStarting at: $69.00
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MDL 72527
MDL 72527 is a polyamine oxidase (POA) inhibitor that displays anticancer and neuroprotective activity in vivo. Learn MoreStarting at: $109.00
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GPi 688
GPi 688 is an allosteric glycogen phosphorylase inhibitor that inhibits glucagon-mediated hyperglycemia in vivo in the rat. Learn MoreStarting at: $179.00
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NU 1025
NU 1025 is a novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP). Learn MoreStarting at: $105.00
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DuP 697
DuP 697 is a potent and selective inhibitor of cyclooxygenase-2 with IC50 values of10 and 800 nM for COX-2 and COX-1 respectively. Learn MoreStarting at: $115.00
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(S)-Methylisothiourea sulfate
(S)-Methylisothiourea sulfate is a highly selective, potent competitive inhibitor of iNOS. Learn MoreStarting at: $79.00
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AMG 548
AMG 548 is a potent and selective inhibitor of p38α (Ki values are 0.5, 3.6, 2600 and 4100 nM for p38α, p38β, p38γ and p38δ respectively). Displays >1000-fold selectivity against 36 other kinases; inhibits whole blood LPS-stimulated TNFα (IC50 = 3 nM). Efficacious in acute and chronic models of arthritis. Learn MoreStarting at: $189.00
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RHC 80267
RHC 80267 is an inhibitor of diacylglycerol lipase that potentiates acetylcholine evoked relaxation in mesenteric arteries by the inhibition of cholinesterase activity. Learn MoreStarting at: $99.00
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Voglibose
Voglibose increases glucagon-like peptide 1 (GLP-1) secretion and decreases food consumption in ob/ob mice, and reduces plasma concentrations of glucose, triglycerides and insulin in Wistar fatty rats. Learn MoreStarting at: $119.00
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CI 898 trihydrochloride
CI 898 trihydrochloride is a potent lipophilic inhibitor of dihydrofolate reductase (DHFR) that inhibits protozoal, bacterial and human DHFR with IC50 values of 1.4, 6.1 and 3.2 nM respectively. Learn MoreStarting at: $139.00
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10Z-Hymenialdisine
10Z-Hymenialdisine is a pan kinase inhibitor that inhibits NF-κB activation and blocks IL-8 production in U937 cells with IC50 values of 1-2 and 0.34-0.48 μM respectively. Learn MoreStarting at: $259.00
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Cilastatin sodium
Cilastatin sodium is a dipeptidase inhibitor that inhibits metabolism of LTD4 to LTE4 and the hydrolysis of β-lactam antibiotics. Learn MoreStarting at: $89.00
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N-Nonyldeoxynojirimycin
N-Nonyldeoxynojirimycin is a glucosidase inhibitor that inhibits liver glycogen breakdown in vivo. Learn MoreStarting at: $139.00
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Trequinsin hydrochloride
Trequinsin hydrochloride is an extremely potent inhibitor of cGMP-inhibited phosphodiesterase that inhibits arachidonic acid-induced aggregation of human platelets. Learn MoreStarting at: $199.00
