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Search results for 'CT 47098'
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CRT 0066101
CRT 0066101 is a potent inhibitor of protein kinase D (PKD), which inhibits all PKD isoforms (IC50 values are 1, 2 and 2.5 nM for PKD1, PKD3 and PKD2 respectively). Learn MoreStarting at: $199.00
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RuBi-Dopa
RuBi-Dopa is a RuBi-caged dopamine; exhibits two-photon sensitivity, and enables non-invasive, optical activation of dopamine receptors with the spatial resolution of a single dendritic spine. Learn MoreStarting at: $199.00
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PF 04885614
PF 04885614 is a potent NaV1.8 inhibitor (IC50 = 53 nM for human NaV1.8 channel), which exhibits selectivity for hNaV1.8 over hNaV1.6, hNaV1.7, hNaV1.1, hNaV1.2 and hNaV1.5 (IC50 values are 4.2, 7.0, 11, 16 and 27 μM respectively). Learn MoreStarting at: $125.00
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SGC-CBP30
SGC-CBP30 is a potent CREBBP/EP300 bromodomain inhibitor (IC50 values are 21-69 and 38 nM for CREBBP and EP300 bromodomains respectively), which displays over 40-fold selectivity for CREBBP over BRD4(1). Learn MoreStarting at: $199.00
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MIM1
MIM1 is an inhibitor of Mcl-1, which selectively targets the BH3-binding pocket. Induces caspase-3/7 activation and cell death in Mcl-1-dependent leukemia cells. Learn MoreStarting at: $125.00
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Bromosporine
Bromosporine is a broad spectrum bromodomain inhibitor, which accelerates FRAP recovery of BRD4 and CREBBP in cells at a concentration of 1 μM. Learn MoreStarting at: $199.00
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±-AMG 487
±-AMG 487 is an antagonist of CXCR3; inhibits binding of 125I-IP-10 and 125I-ITAC to CXCR3 (IC50 values are 8.0 and 8.2 nM respectively), which inhibits CXCR3-mediated cell migration by the chemokines IP-10, ITAC and MiG in vitro (IC50 values are 8, 15 and 36 nM respectively). Learn MoreStarting at: $189.00
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(Z)-FeCP-oxindole
(Z)-FeCP-oxindole is a selective inhibitor of human vascular endothelial cell growth factor receptor 2 (VEGFR-2) (IC50 = 220 nM), which displays anticancer activity (IC50< 1 μM against B16 murine melanoma lines). Learn MoreStarting at: $179.00
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PF 750
PF 750 is an irreversible fatty acid amide hydrolase (FAAH) inhibitor that displays no activity at a range of other serine hydrolases. Learn MoreStarting at: $149.00
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PHA 767491 hydrochloride
PHA 767491 hydrochloride is a potent, ATP-competitive dual cdc7/cdk9 inhibitor with IC50 valuesof 10 and 34 nM respectively. Learn MoreStarting at: $99.00
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PI 828
PI 828 is a PI 3-Kinase inhibitor with IC50 values of 0.098, 0.183, 0.227 and 1.967 μM for p110β, p110α, p110δ and p110γ respectively. Learn MoreStarting at: $69.00
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MDL 72527
MDL 72527 is a polyamine oxidase (POA) inhibitor that displays anticancer and neuroprotective activity in vivo. Learn MoreStarting at: $109.00
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FPA 124
FPA 124 is an Akt/PKB inhibitor that inhibits cell proliferation in various cancer cell lines in vitro and decreases NF-κB activity and tumor load in vivo. Learn MoreStarting at: $125.00
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DuP 697
DuP 697 is a potent and selective inhibitor of cyclooxygenase-2 with IC50 values of10 and 800 nM for COX-2 and COX-1 respectively. Learn MoreStarting at: $115.00
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(S)-Methylisothiourea sulfate
(S)-Methylisothiourea sulfate is a highly selective, potent competitive inhibitor of iNOS. Learn MoreStarting at: $79.00
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AMG 548
AMG 548 is a potent and selective inhibitor of p38α (Ki values are 0.5, 3.6, 2600 and 4100 nM for p38α, p38β, p38γ and p38δ respectively). Displays >1000-fold selectivity against 36 other kinases; inhibits whole blood LPS-stimulated TNFα (IC50 = 3 nM). Efficacious in acute and chronic models of arthritis. Learn MoreStarting at: $189.00
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Vialinin A
Vialinin A is an inhibitor of ubiquitin-specific peptidase 4 (USP4), USP5/isopeptidase T (IsoT) and UCH-L1 deubiquitinating enzyme (DUB) activity. Learn MoreStarting at: $65.00
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K-252c
K-252c is an inhibitor of protein kinase C that exhibits antiviral activity against GCV-sensitive and -resistant strains of human cytomegalovirus (HCMV). Learn MoreStarting at: $99.00
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PF 915275
PF 915275 is a potent and selective 11β-hydroxysteroid dehydrogenase type 1 (11βHSD1) inhibitor that inhibits the conversion of prednisone to prednisolone in human hepatocytes in vitro and has antidiabetic activity in vivo. Learn MoreStarting at: $115.00
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TCS 2312
TCS 2312 is a potent and selective checkpoint kinase 1 (chk1) inhibitor that enhances the cell killing activity of Gemcitabine in breast and prostate cancer cell lines and displays antiproliferative effects in vitro. Learn MoreStarting at: $139.00
