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Search results for 'AG 490'
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RuBi-Dopa
RuBi-Dopa is a RuBi-caged dopamine; exhibits two-photon sensitivity, and enables non-invasive, optical activation of dopamine receptors with the spatial resolution of a single dendritic spine. Learn MoreStarting at: $199.00
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±-AMG 487
±-AMG 487 is an antagonist of CXCR3; inhibits binding of 125I-IP-10 and 125I-ITAC to CXCR3 (IC50 values are 8.0 and 8.2 nM respectively), which inhibits CXCR3-mediated cell migration by the chemokines IP-10, ITAC and MiG in vitro (IC50 values are 8, 15 and 36 nM respectively). Learn MoreStarting at: $189.00
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(Z)-FeCP-oxindole
(Z)-FeCP-oxindole is a selective inhibitor of human vascular endothelial cell growth factor receptor 2 (VEGFR-2) (IC50 = 220 nM), which displays anticancer activity (IC50< 1 μM against B16 murine melanoma lines). Learn MoreStarting at: $179.00
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GPi 688
GPi 688 is an allosteric glycogen phosphorylase inhibitor that inhibits glucagon-mediated hyperglycemia in vivo in the rat. Learn MoreStarting at: $179.00
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TCS JNK 6o
TCS JNK 6o is an ATP-competitive c-Jun N-terminal kinase (JNK) inhibitor that inhibits c-Jun phosphorylation (EC50 = 920 nM) and prevents collagen-induced platelet aggregation in vitro. Learn MoreStarting at: $149.00
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AMG 548
AMG 548 is a potent and selective inhibitor of p38α (Ki values are 0.5, 3.6, 2600 and 4100 nM for p38α, p38β, p38γ and p38δ respectively). Displays >1000-fold selectivity against 36 other kinases; inhibits whole blood LPS-stimulated TNFα (IC50 = 3 nM). Efficacious in acute and chronic models of arthritis. Learn MoreStarting at: $189.00
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K-252c
K-252c is an inhibitor of protein kinase C that exhibits antiviral activity against GCV-sensitive and -resistant strains of human cytomegalovirus (HCMV). Learn MoreStarting at: $99.00
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Voglibose
Voglibose increases glucagon-like peptide 1 (GLP-1) secretion and decreases food consumption in ob/ob mice, and reduces plasma concentrations of glucose, triglycerides and insulin in Wistar fatty rats. Learn MoreStarting at: $119.00
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SA 47
SA 47 is a selective inhibitor of fatty acid amide hydrolase (FAAH) that exhibits greater selectivity for FAAH than URB 597 against multiple carboxylesterases. Learn MoreStarting at: $109.00
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Trequinsin hydrochloride
Trequinsin hydrochloride is an extremely potent inhibitor of cGMP-inhibited phosphodiesterase that inhibits arachidonic acid-induced aggregation of human platelets. Learn MoreStarting at: $199.00
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Oncrasin 1
Oncrasin 1 is a proapoptotic agent that exhibits antiproliferative effects against various human tumor cell lines with K-Ras mutations (IC50 ≤ 3 μM) with minimal effects on normal epithelial cells and inhibits human xenograft growth by 75% in vivo. Learn MoreStarting at: $105.00
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ZJ 43
ZJ 43 is a potent inhibitor of glutamate carboxypeptidase II and III (GCP II and III/NAAG peptidase/NAALADase) that inhibits the hydrolysis of NAAG (IC50 = 2.4 nM). Learn MoreStarting at: $89.00
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UAMC 00039 dihydrochloride
UAMC 00039 dihydrochloride is potent inhibitor of dipeptidyl peptidase II (DPP-II) with selectivity for DPP-II against DPP-9, DPP-8 and DPP-IV. Learn MoreStarting at: $169.00
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SKF 91488 dihydrochloride
SKF 91488 dihydrochloride is a strong inhibitor of histamine N-methyltransferase with no histamine agonist activity. Learn MoreStarting at: $69.00
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MRK 560
MRK 560 inhibits proteolytic cleavage of amyloid precursor protein (APP) over the Notch pathway. Learn MoreStarting at: $149.00
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Xanthohumol
Xanthohumol is a Valosin-containing protein (VCP) inhibitor that binds to the N domain of VCP, suppressing function and impairing autophagosome maturation. Learn MoreStarting at: $139.00
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MeBIO
MeBIO is an Aryl hydrocarbon receptor (AhR) agonist that causes redistribution of AhR to the nucleus. Learn MoreStarting at: $119.00
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JLK 6
JLK 6 is inhibitor of γ-secretase that selectively inhibits βAPP cleavage without affecting other γ-secretase-mediated pathways. Learn MoreStarting at: $109.00
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Acyclovir
Acyclovir, an antiviral agent, is active against herpes simplex viruses HSV-1 and HSV-2 with EC50 values of 0.85 and 0.86 μM respectively. Learn MoreStarting at: $59.00
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Cystamine dihydrochloride
Cystamine dihydrochloride is a transglutaminase inhibitor.It decreases aggregated and cross-linked huntingtin in transfected cells, and increases brain levels of BDNF. Shown to extend survival and improve motor performance in transgenic HD mice. Learn MoreStarting at: $29.00
