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Decynium 22
Decynium 22 is an inhibitor of the plasma membrane monoamine transporter (PMAT) (Ki = 0.10 μM). Learn MoreStarting at: $49.00
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VU 0240551
VU 0240551 is an inhibitor of the neuronal K-Cl cotransporter, KCC2 that also inhibits hERG and L-type Ca2+ channels. Learn MoreStarting at: $115.00
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LY 2365109 hydrochloride
LY 2365109 hydrochloride is a potent and selective glycine transporter 1 (GlyT1) inhibitor that induces a dose-dependent elevation in CSF levels of glycine, and enhances acetylcholine and dopamine release in the striatum and prefrontal cortex respectively. Learn MoreStarting at: $149.00
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YM 244769
YM 244769 is an inhibitor of the reverse mode of Na+/Ca2+ exchange (NCX) that inhibits Na+-dependent 45Ca2+ uptake with IC50 values of 18, 68 and 96 nM for CCL39 cells transfected with NCX3, NCX1 and NCX2 respectively. Learn MoreStarting at: $125.00
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Concanamycin A
Concanamycin A is a specific inhibitor of V-type (vacuolar) H+-ATPase that blocks cell surface expression of virus envelope glycoproteins without affecting synthesis and exhibits cytotoxicity in several cell lines. Learn MoreStarting at: $99.00
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SCH 28080
SCH 28080 is a potent inhibitor of H+,K+-ATPase that binds to the K+ recognition site and is competitive with respect to K+. Learn MoreStarting at: $139.00
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CGP 37157
CGP 37157 is a selective antagonist of the mitochondrial Na+-Ca2+ exchanger with an IC50 of 0.4 μM. Learn MoreStarting at: $139.00
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Org 24598 lithium salt
Org 24598 lithium salt is a selective inhibitor of the glial glycine transporter (GlyT1). pIC50 values are 6.9, <4 and <3 for GlyT1, GABA transporter and Glyt2 respectively. Learn MoreStarting at: $139.00
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Talopram hydrochloride
Talopram hydrochloride is a potent, selective inhibitor of the noradrenalin transporter (NET) with selectivity for NET against SERT (5-HT transporters) and DAT (dopamine transporters). Learn MoreStarting at: $139.00
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Bicifadine hydrochloride
Bicifadine hydrochloride is an orally active, potent antagonist of the noradrenalin transporter with antagonist activity at the 5-HT and dopamine transporters (IC50 values are 117 nM and 910 nM respectively). Learn MoreStarting at: $139.00
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Paroxetine maleate
Paroxetine maleate is a highly potent and selective 5-HT uptake inhibitor that binds with high affinity to the serotonin transporter. Learn MoreStarting at: $90.00
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Paxilline
Paxilline, a potent blocker of high-conductance Ca2+-activated K+ (BKCa, KCa1.1) channels, binds to the α-subunit of BKCa (Ki = 1.9 nM for block of currents in α-subunit-expressing oocytes) and enhances binding of charybdotoxin to BKCa channels in vascular smooth muscle. Learn MoreStarting at: $198.00
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Fluoxetine hydrochloride
Fluoxetine hydrochloride is a selective serotonin reuptake inhibitor. It binds to the human 5-HT transporter with a Ki of 0.9 nmol/l and is between 150- and 900- fold selective over 5-HT1A, 5-HT2A, H1, α1, α2-adrenergic, and muscarinic receptors. Learn MoreStarting at: $69.00
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Lithium carbonate
Lithium carbonate is thought to act by reducing catecholamine neurotransmitter concentration, through an effect on the Na+/K+ ATPase pump. Learn MoreStarting at: $29.00
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(S)-SNAP 5114
BTS is a selective inhibitor of the ATPase activity of skeletal muscle myosin II subfragment 1 (S1) (IC50 ~ 5 mM), reversibly blocks gliding motility and suppresses force and twitch production in fast skeletal muscle. Learn MoreStarting at: $135.00
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Org 25543 hydrochloride
Org 25543 hydrochloride is a potent and selective glycine transporter type 2 (GlyT2) inhibitor (IC50 = 16 nM for hGlyT2), which displays no activity at GlyT1 or 56 other common biological targets (≥ 100 μM), in a glycine uptake assay in CHO cells. Learn MoreStarting at: $139.00
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NFPS
NFPS is a selective, non-transportable inhibitor of GlyT1 which displays no activity on GlyT2 or the transport of proline, GABA or glutamate (IC50 values are 2.8, 9.8 and 56000 nM for hGlyT1, rGlyT1 and rGlyT2 respectively). Learn MoreStarting at: $139.00
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UCM 707
UCM 707 is a potent endocannabinoid transport inhibitor. IC50 values are 0.8 and 30 μM for inhibition of the anandamide transporter and FAAH respectively. Ki values are 4700, 67 and > 5000 nM for CB1, CB2 and VR1 receptors respectively. Learn MoreStarting at: $125.00
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WY 45233 succinate
WY 45233 succinate is a serotonin and noradrenalin reuptake inhibitor (SNRI); selective for human serotonin (SERT) and noradrenalin (NET) transporters against 96 other targets (Ki values are 40.2 and 558.4 nM for SERT and NET respectively). Learn MoreStarting at: $149.00
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VDM 11
VDM 11 is a potent and selective inhibitor of the anandamide membrane transporter (AMT) with IC50 values of 4-11 μM, which displays negligible agonist activity at the hVR1 receptor and very weak action at CB1 and CB2 receptors. Learn MoreStarting at: $75.00
