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Search results for 'PR 171'
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LY 2365109 hydrochloride
LY 2365109 hydrochloride is a potent and selective glycine transporter 1 (GlyT1) inhibitor that induces a dose-dependent elevation in CSF levels of glycine, and enhances acetylcholine and dopamine release in the striatum and prefrontal cortex respectively. Learn MoreStarting at: $149.00
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BTS 54-505 hydrochloride
BTS 54-505 hydrochloride is a potently active primary amine metabolite of sibutramine. Learn MoreStarting at: $95.00
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Concanamycin A
Concanamycin A is a specific inhibitor of V-type (vacuolar) H+-ATPase that blocks cell surface expression of virus envelope glycoproteins without affecting synthesis and exhibits cytotoxicity in several cell lines. Learn MoreStarting at: $99.00
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Talopram hydrochloride
Talopram hydrochloride is a potent, selective inhibitor of the noradrenalin transporter (NET) with selectivity for NET against SERT (5-HT transporters) and DAT (dopamine transporters). Learn MoreStarting at: $139.00
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L-trans-2,4-PDC
L-trans-2,4-PDC is a potent, competitive, transportable EAAT1-4 inhibitor/non-transportable EAAT5 inhibitor. Learn MoreStarting at: $115.00
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Citalopram hydrobromide
Citalopram hydrobromide is a highly selective and potent 5-HT uptake inhibitor with no effect on noradrenalin or dopamine uptake with IC50 values of 1.8, 8800 and 41000 nM respectively. Learn MoreStarting at: $105.00
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Desipramine hydrochloride
Desipramine hydrochloride is a tricyclic antidepressant that is a selective inhibitor of noradrenalin transporters with Ki values of 4, 61 and 78720 nM for NET, SERT and DAT transporters respectively. Learn MoreStarting at: $41.00
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Paxilline
Paxilline, a potent blocker of high-conductance Ca2+-activated K+ (BKCa, KCa1.1) channels, binds to the α-subunit of BKCa (Ki = 1.9 nM for block of currents in α-subunit-expressing oocytes) and enhances binding of charybdotoxin to BKCa channels in vascular smooth muscle. Learn MoreStarting at: $198.00
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(S)-SNAP 5114
BTS is a selective inhibitor of the ATPase activity of skeletal muscle myosin II subfragment 1 (S1) (IC50 ~ 5 mM), reversibly blocks gliding motility and suppresses force and twitch production in fast skeletal muscle. Learn MoreStarting at: $135.00
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SN-6
SN-6 is a selective Na+/Ca2+-exchange (NCX) inhibitor which displays some selectivity for NCX1. IC50 values are 2.9, 16 and 8.6 μM for inhibition of intracellular Na+-dependent 45Ca2+ uptake by cells expressing NCX1, NCX2 and NCX3 respectively. Learn MoreStarting at: $115.00
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NFPS
NFPS is a selective, non-transportable inhibitor of GlyT1 which displays no activity on GlyT2 or the transport of proline, GABA or glutamate (IC50 values are 2.8, 9.8 and 56000 nM for hGlyT1, rGlyT1 and rGlyT2 respectively). Learn MoreStarting at: $139.00
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Bupropion hydrochloride
Bupropion hydrochloride is a non-selective inhibitor of dopamine and noradrenalin transporters (Ki values are 1.4, 2.8 and 45 μM for NET, DAT and SERT transporters respectively), which also inhibits neuronal nicotinic acetylcholine receptors. Learn MoreStarting at: $99.00
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Reversan
Reversan is a selective inhibitor of multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (P-gp). Increases the sensitivity of MRP1-overexpressing tumor cells (MCF7/VP) to doxorubicin, vincristine and etoposide by 3.8-, 14.6- and 11.6-fold respectively. Learn MoreStarting at: $139.00
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Talsupram hydrochloride
Talsupram hydrochloride is a selective noradrenalin re-uptake inhibitor which exhibits a high affinity for the human noradrenalin transporter (NET) against SERT and DAT (IC50 values are 0.79, 850 and 9300 nM for inhibition of monoamine uptake by NET, SERT and DAT respectively). Learn MoreStarting at: $129.00
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Lofepramine
Lofepramine is a serotonin and noradrenalin re-uptake inhibitor (SNRI) that is metabolized to desipramine, which produces inhibition of liver tryptophan pyrollase activity in vitro and displays antidepressant properties in vivo. Learn MoreStarting at: $90.00
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(±)-HIP-B
(±)-HIP-B is a potent, non-competitive excitatory amino acid transporter (EAAT) blocker which preferentially inhibits glutamate-induced [3H]D-aspartate release (IC50 = 1.2 μM) rather than [3H]L-glutamate uptake (IC50 = 16.9 μM). Learn MoreStarting at: $139.00
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(±)-HIP-A
(±)-HIP-A is a potent, non-competitive excitatory amino acid transporter (EAAT) blocker which preferentially inhibits glutamate-induced [3H]D-aspartate release (IC50 = 1.6 μM) rather than [3H]L-glutamate uptake (IC50 = 18 μM). Learn MoreStarting at: $139.00
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Escitalopram oxalate
Escitalopram oxalate is a selective serotonin reuptake inhibitor (SSRI) (Ki values are 0.89, 8150, and 10500 nM for serotonin, noradrenalin, and dopamine transporters respectively). Learn MoreStarting at: $55.00
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JHW 007 hydrochloride
JHW 007 hydrochloride is a dopamine uptake inhibitor which displays high affinity for the dopamine transporter (DAT) (Ki = 25 nM compared to 1330 and 1730 for NET and SERT respectively), and suppresses the effects of cocaine administration in a dose-dependent manner. Learn MoreStarting at: $120.00
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Dilazep dihydrochloride
Dilazep dihydrochloride is a coronary and cerebral vasodilator, suppresses the effects of ischemia. Learn MoreStarting at: $90.00
