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Y 134
Y 134 is a selective estrogen receptor modulator (SERM) that acts as an agonist in the bone and antagonist in reproductive tissue. Learn MoreStarting at: $139.00
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RU 28318 (potassium salt)
RU 28318 (potassium salt) is a potent and selective antagonist for the mineralocorticoid receptor (MR) that inhibits aldosterone production and secretion, and selectively decreases ex-vivo MR binding in the hippocampus of adrenalectomised rats. Learn MoreStarting at: $139.00
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TCPOBOP
TCPOBOP is an agonist of the constitutive androstane receptor that induces activity of ER1 cytochrome P450 isozymes, NADPH-cytochrome c reductase, microsomal epoxide hydrolase and glutathione S transferase. Learn MoreStarting at: $79.00
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Docosahexaenoic acid
Docosahexaenoic acid is a endogenous omega-3 fatty acid. It acts as a selective retinoid X receptor (RXR) agonist that displays no activity at RAR, thyroid hormone receptor or the vitamin D receptor (VDR). Learn MoreStarting at: $75.00
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AC 55649
AC 55649 is a potent, isoform-selective RARβ2 receptor agonist that displays 100-fold selectivity versus other retinoid receptors. Inhibits proliferation of the breast cancer cell line MCF-7. Learn MoreStarting at: $99.00
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BADGE
RS 39604 hydrochloride is a potent and selective 5-HT4 antagonist, with a pKi of 9.1 at 5-HT4 receptors in guinea pig striatal membranes and greater than 1000-fold selectivity over 5-HT1A, 2C, 3 and D1, D2, M1, M2, AT1, B1 and α1C receptors. Learn MoreStarting at: $80.00
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ITE
ITE is an endogenous agonist for the transcription factor aryl hydrocarbon receptor (AHR); Ki = 3 nM for binding to murine AHR. Learn MoreStarting at: $139.00
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GW 3965 hydrochloride
GW 3965 hydrochloride is a selective, orally active non-steroidal agonist for the liver X receptor (LXR). Learn MoreStarting at: $85.00
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S26948
S26948 is a selective PPARγ agonist (EC50 = 8.83 nM), which drives normal adipocyte differentiation and exhibits a lipid-lowering effect; reduces atherosclerosis in E2-KI mice, and displays antidiabetic properties and improves hepatic insulin sensitivity in intralipid-infusion (IL) rats. Learn MoreStarting at: $139.00
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MM 11253
MM 11253 is a selective RARγ antagonist, which blocks the growth inhibitory ability of RARγ-selective agonists in squamous cell carcinoma (SCC)-25 cells. Learn MoreStarting at: $139.00
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Phortress
Phortress is a prodrug of the antitumor agent 5F 203, which acts via binding to aryl hydrocarbon receptors. Learn MoreStarting at: $155.00
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CH 223191
CH 223191 is a potent and specific aryl hydrocarbon receptor (AhR) antagonist, which displays no AhR agonist activity (at concentrations up to 100 μM) and blocks binding of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) to the AhR in a dose-dependent manner. Learn MoreStarting at: $109.00
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L-Kynurenine
Tryptophan catabolite; endogenous activator of the aryl hydrocarbon receptor (AhR). Learn MoreStarting at: $39.00
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PPT
PPT is a potent, subtype-selective estrogen receptor agonist (EC50 ~ 200 pM) which displays 410-fold selectivity for ERα over ER&beta, and prevents ovariectomy-induced weight gain and loss of bone mineral density, and induces gene expression in the hypothalamus following systemic administration in vivo. Learn MoreStarting at: $119.00
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GC 1
GC 1 is a thyromimetic; high affinity agonist at thyroid hormone receptor (TR) β and TRα receptors (KD values are 67 and 440 pM respectively), which displays 5- and 100-fold greater potency than the endogenous agonist T3 in vitro at TRα1 and TRβ1 receptors respectively. Learn MoreStarting at: $115.00
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HX 630
HX 630 is a RXR agonist, which acts as a retinoid synergist and enhances the potency of AM 80 in a HL-60 cell differentiation assay. Learn MoreStarting at: $149.00
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DLPC
DLPC is a selective agonist of the orphan nuclear receptor LRH-1 (liver receptor homolog-1, NR5A2) in vitro, which induces bile acid biosynthetic enzymes; increases bile acid and decreases hepatic triglycerides and serum glucose, and exhibits antidiabetic effects. Learn MoreStarting at: $50.00
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LG 100754
LG 100754 is a novel RXR:PPARγ agonist; sensitizes PPARγ by enhancing its ligand binding activity which displays selectivity over other permissive heterodimers such as RXR:LXRα and RXR:BAR/FXR. Learn MoreStarting at: $140.00
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ZK 164015
ZK 164015 is a potent estrogen receptor silent antagonist which inhibits 17β-estradiol stimulation of luciferase activity (IC50 = 0.025 μM); potently inhibits the growth of estrogen-sensitive human MCF-7 breast cancer cells in vitro (IC50 ~ 1 nM). Learn MoreStarting at: $115.00
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AC 45594
AC 45594 is a selective inverse agonist at the orphan nuclear receptor steroidogenic factor-1 (SF-1) (IC50= 50 - 100 nM), which inhibits SFRE-mediated transcription. Learn MoreStarting at: $70.00
