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Search results for 'inhibit'
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SID 7969543
SID 7969543 is a selective steroidogenic factor-1 (SF-1, NR5A1) inhibitor that inhibits SF-1-dependent luciferase expression in HEK 293T cells in vitro with an IC50 value of 30 nM). Learn MoreStarting at: $89.00
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RU 28318 (potassium salt)
RU 28318 (potassium salt) is a potent and selective antagonist for the mineralocorticoid receptor (MR) that inhibits aldosterone production and secretion, and selectively decreases ex-vivo MR binding in the hippocampus of adrenalectomised rats. Learn MoreStarting at: $139.00
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SR 202
SR 202 is a selective PPARγ antagonist that inhibits PPARγ-dependent adipocyte differentiation and growth in vitro and in vivo. Learn MoreStarting at: $90.00
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Estropipate
Estropipate is an estrogen receptor agonist that inhibits organic anion transporting polypeptide 1B1 (OATP1B1). Learn MoreStarting at: $75.00
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AC 55649
AC 55649 is a potent, isoform-selective RARβ2 receptor agonist that displays 100-fold selectivity versus other retinoid receptors. Inhibits proliferation of the breast cancer cell line MCF-7. Learn MoreStarting at: $99.00
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CD 2665
SC 236 is a selective COX-2 inhibitor (IC50 values are 0.005 and 17.8 μM for COX-2 and COX-1 respectively) which displays anti-inflammatory properties and potent antimetastatic activity against both experimental metastases and spontaneous metastases arising following primary tumor excision. Learn MoreStarting at: $140.00
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BMS 453
R-96544 hydrochloride is a potent, selective 5-HT2 receptor antagonist which displays some selectivity for 5-HT2A receptors (Ki = 1.6 nM) and inhibits 5-HT-induced platelet aggregation and pressor responses in vivo. Learn MoreStarting at: $135.00
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MM 11253
MM 11253 is a selective RARγ antagonist, which blocks the growth inhibitory ability of RARγ-selective agonists in squamous cell carcinoma (SCC)-25 cells. Learn MoreStarting at: $139.00
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Cl-4AS-1
Cl-4AS-1 is a potent steroidal androgen receptor agonist (IC50 = 12 nM), which inhibits 5α-reductase type I and II (IC50 values are 6 and 10 nM respectively). Learn MoreStarting at: $140.00
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ZK 164015
ZK 164015 is a potent estrogen receptor silent antagonist which inhibits 17β-estradiol stimulation of luciferase activity (IC50 = 0.025 μM); potently inhibits the growth of estrogen-sensitive human MCF-7 breast cancer cells in vitro (IC50 ~ 1 nM). Learn MoreStarting at: $115.00
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AC 45594
AC 45594 is a selective inverse agonist at the orphan nuclear receptor steroidogenic factor-1 (SF-1) (IC50= 50 - 100 nM), which inhibits SFRE-mediated transcription. Learn MoreStarting at: $70.00
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SR 8278
SR 8278 is a Rev-Erbα antagonist; inhibits Rev-Erbα transcriptional repression (EC50 = 0.47 μM) and blocks activity of Rev-Erbα agonist GSK 4112 in HEK293 cells. Learn MoreStarting at: $115.00
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GSK 9027
GSK 9027 is a glucocorticoid receptor agonist (pIC50 = 8), which inhibits production of the proinflammatory mediator IL-6 in vivo. Learn MoreStarting at: $135.00
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Ch 55
Ch 55 is a highly potent synthetic retinoid that has high affinity for RAR-α and RAR-β receptors and low affinity for cellular retinoic acid binding protein (CRABP) and Inhibits rabbit tracheal epithelial cell differentiation by inhibiting transglutaminase and increasing cholesterol sulfate (EC50 values are 0.02 and 0.03 nM respectively). Learn MoreStarting at: $90.00
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22-Oxacalcitriol
22-Oxacalcitriol is non-calcemic vitamin D3 analog and VDR ligand, which inhibits tumor growth of osteosarcoma in vitro in combination with all-trans retinoic acid. Learn MoreStarting at: $125.00
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Spironolactone
Spironolactone is a competitive mineralocorticoid (aldosterone) receptor antagonist that exhibits antihypertensive activity in vivo, displays antiandrogen activity and inhibits steroid hormone biosynthesis. Learn MoreStarting at: $45.00
