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Search results for 'PR 171'
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Guggulsterone
Guggulsterone is a broad spectrum steroid receptor ligand that binds with high affinity to mineralocorticoid receptors and lower affinity to progesterone, androgen and glucocorticoid receptors. Learn MoreStarting at: $109.00
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SID 7969543
SID 7969543 is a selective steroidogenic factor-1 (SF-1, NR5A1) inhibitor that inhibits SF-1-dependent luciferase expression in HEK 293T cells in vitro with an IC50 value of 30 nM). Learn MoreStarting at: $89.00
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Y 134
Y 134 is a selective estrogen receptor modulator (SERM) that acts as an agonist in the bone and antagonist in reproductive tissue. Learn MoreStarting at: $139.00
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RU 28318 (potassium salt)
RU 28318 (potassium salt) is a potent and selective antagonist for the mineralocorticoid receptor (MR) that inhibits aldosterone production and secretion, and selectively decreases ex-vivo MR binding in the hippocampus of adrenalectomised rats. Learn MoreStarting at: $139.00
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RU 26752
RU 26752 is a mineralocorticoid receptor antagonist that prevents aldosterone-induced hypertension in rats. Learn MoreStarting at: $89.00
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AC 55649
AC 55649 is a potent, isoform-selective RARβ2 receptor agonist that displays 100-fold selectivity versus other retinoid receptors. Inhibits proliferation of the breast cancer cell line MCF-7. Learn MoreStarting at: $99.00
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Tacalcitol
Tacalcitol promotes normal bone development by regulating calcium and modulates immunological and inflammatory processes. Learn MoreStarting at: $169.00
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CD 2665
SC 236 is a selective COX-2 inhibitor (IC50 values are 0.005 and 17.8 μM for COX-2 and COX-1 respectively) which displays anti-inflammatory properties and potent antimetastatic activity against both experimental metastases and spontaneous metastases arising following primary tumor excision. Learn MoreStarting at: $140.00
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BMS 453
R-96544 hydrochloride is a potent, selective 5-HT2 receptor antagonist which displays some selectivity for 5-HT2A receptors (Ki = 1.6 nM) and inhibits 5-HT-induced platelet aggregation and pressor responses in vivo. Learn MoreStarting at: $135.00
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Z-Guggulsterone
Z-Guggulsterone is a broad spectrum steroid receptor ligand; mineralocorticoid, progesterone and glucocorticoid receptor antagonist (Ki values are 37, 224 and 252 nM respectively) and weak androgen receptor agonist (Ki = 315 nM). Learn MoreStarting at: $139.00
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S26948
S26948 is a selective PPARγ agonist (EC50 = 8.83 nM), which drives normal adipocyte differentiation and exhibits a lipid-lowering effect; reduces atherosclerosis in E2-KI mice, and displays antidiabetic properties and improves hepatic insulin sensitivity in intralipid-infusion (IL) rats. Learn MoreStarting at: $139.00
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Phortress
Phortress is a prodrug of the antitumor agent 5F 203, which acts via binding to aryl hydrocarbon receptors. Learn MoreStarting at: $155.00
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PPT
PPT is a potent, subtype-selective estrogen receptor agonist (EC50 ~ 200 pM) which displays 410-fold selectivity for ERα over ER&beta, and prevents ovariectomy-induced weight gain and loss of bone mineral density, and induces gene expression in the hypothalamus following systemic administration in vivo. Learn MoreStarting at: $119.00
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BMS 195614
BMS 195614 is a neutral retinoic acid receptor (RAR) α-selective antagonist (Ki = 2.5 nM) which displays no significant effect on nuclear receptor corepressor (NCoR) binding; moderately decreases SMRT binding to RAR. Learn MoreStarting at: $159.00
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BMS 493
BMS 493 is a pan-retinoic acid receptor (pan-RAR) inverse agonist, which enhances nuclear corepressor (NCoR) interaction with RARs. Learn MoreStarting at: $135.00
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GW 1929 hydrochloride
GW 1929 hydrochloride is a highly selective orally active peroxisome proliferator-activated receptor (PPAR)γ agonist (pEC50 values are 8.05, < 4 and < 4 for human PPARγ, PPARα and PPARδ receptors respectively). Learn MoreStarting at: $135.00
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GSK 3787
GSK 3787 is a potent and selective peroxisome proliferator-activated receptor δ (PPARδ) antagonist (pIC50 = 6.6), which displays no measurable affinity for PPARα or PPARγ in vitro (pIC50< 5). Learn MoreStarting at: $69.00
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TFM-4AS-1
TFM-4AS-1 is a potent selective androgen receptor modulator (SARM) (IC50 = 30 nM), which exhibits limited effects on reproductive tissues and sebaceous glands; does not repress AP-1-sensitive MMP-1 reporter. Learn MoreStarting at: $140.00
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RU 58668
RU 58668 is a pure antiestrogen that downregulates estrogen receptor expression (IC50 = 0.04 nM), which displays potent antiproliferative activity in vitro (IC50 = 0.035 - 0.09 nM in MCF-7 cells) and causes long term regression of tamoxifen-resistant MCF-7 xenografts in vivo. Learn MoreStarting at: $185.00
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DiMNF
DiMNF is a selective aryl hydrocarbon receptor (AHR) modulator (SAhRM) which suppresses expression of CD55 and CD46 induced by IL-1β Learn MoreStarting at: $110.00
