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Search results for 'PI'
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Estropipate
Estropipate is an estrogen receptor agonist that inhibits organic anion transporting polypeptide 1B1 (OATP1B1). Learn MoreStarting at: $75.00
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BADGE
RS 39604 hydrochloride is a potent and selective 5-HT4 antagonist, with a pKi of 9.1 at 5-HT4 receptors in guinea pig striatal membranes and greater than 1000-fold selectivity over 5-HT1A, 2C, 3 and D1, D2, M1, M2, AT1, B1 and α1C receptors. Learn MoreStarting at: $80.00
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S26948
S26948 is a selective PPARγ agonist (EC50 = 8.83 nM), which drives normal adipocyte differentiation and exhibits a lipid-lowering effect; reduces atherosclerosis in E2-KI mice, and displays antidiabetic properties and improves hepatic insulin sensitivity in intralipid-infusion (IL) rats. Learn MoreStarting at: $139.00
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GSK 3787
GSK 3787 is a potent and selective peroxisome proliferator-activated receptor δ (PPARδ) antagonist (pIC50 = 6.6), which displays no measurable affinity for PPARα or PPARγ in vitro (pIC50< 5). Learn MoreStarting at: $69.00
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DPN
DPN is a highly potent estrogen ERβ receptor agonist with a 70-fold selectivity over ERα (EC50 values are 0.85 and 66 nM respectively), which shown to regulate expression of GluR1, GluR2 and GluR3 in rat hippocampus. Learn MoreStarting at: $90.00
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GSK 9027
GSK 9027 is a glucocorticoid receptor agonist (pIC50 = 8), which inhibits production of the proinflammatory mediator IL-6 in vivo. Learn MoreStarting at: $135.00
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Pioglitazone hydrochloride
Pioglitazone hydrochloride is a selective PPARγ agonist (EC50 = 0.69 μM). Learn MoreStarting at: $45.00
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Ch 55
Ch 55 is a highly potent synthetic retinoid that has high affinity for RAR-α and RAR-β receptors and low affinity for cellular retinoic acid binding protein (CRABP) and Inhibits rabbit tracheal epithelial cell differentiation by inhibiting transglutaminase and increasing cholesterol sulfate (EC50 values are 0.02 and 0.03 nM respectively). Learn MoreStarting at: $90.00
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Spironolactone
Spironolactone is a competitive mineralocorticoid (aldosterone) receptor antagonist that exhibits antihypertensive activity in vivo, displays antiandrogen activity and inhibits steroid hormone biosynthesis. Learn MoreStarting at: $45.00
