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Search results for 'LY 215840'
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RU 28318 (potassium salt)
RU 28318 (potassium salt) is a potent and selective antagonist for the mineralocorticoid receptor (MR) that inhibits aldosterone production and secretion, and selectively decreases ex-vivo MR binding in the hippocampus of adrenalectomised rats. Learn MoreStarting at: $139.00
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Estropipate
Estropipate is an estrogen receptor agonist that inhibits organic anion transporting polypeptide 1B1 (OATP1B1). Learn MoreStarting at: $75.00
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ERB 041
IC50 values of ERB 041 are 5 and 1216 nM for human ERβ and ERα; 3.1 and 620 nM for rat ERβ and ERα; and 3.7 and 750 nM for mouse ERβ and ERα respectively. Learn MoreStarting at: $139.00
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(R)-DPN
(R)-DPN, a enantiomer of DPN, displays higher affinity for estrogen receptor (ER) β over ERα with Ki values of 1.82 and 147 nM respectively . Learn MoreStarting at: $186.00
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CD 2665
SC 236 is a selective COX-2 inhibitor (IC50 values are 0.005 and 17.8 μM for COX-2 and COX-1 respectively) which displays anti-inflammatory properties and potent antimetastatic activity against both experimental metastases and spontaneous metastases arising following primary tumor excision. Learn MoreStarting at: $140.00
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BADGE
RS 39604 hydrochloride is a potent and selective 5-HT4 antagonist, with a pKi of 9.1 at 5-HT4 receptors in guinea pig striatal membranes and greater than 1000-fold selectivity over 5-HT1A, 2C, 3 and D1, D2, M1, M2, AT1, B1 and α1C receptors. Learn MoreStarting at: $80.00
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WAY 200070
WAY 200070 is a selective ERβ receptor agonist that displays 68-fold selectivity over ERα (EC50 values are 2 and 155 nM for ERβ and ERα respectively). Learn MoreStarting at: $109.00
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GW 3965 hydrochloride
GW 3965 hydrochloride is a selective, orally active non-steroidal agonist for the liver X receptor (LXR). Learn MoreStarting at: $85.00
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Z-Guggulsterone
Z-Guggulsterone is a broad spectrum steroid receptor ligand; mineralocorticoid, progesterone and glucocorticoid receptor antagonist (Ki values are 37, 224 and 252 nM respectively) and weak androgen receptor agonist (Ki = 315 nM). Learn MoreStarting at: $139.00
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LG 101506
LG 101506 is a selective RXR modulator (Ki values are 3, 9 and 11 for RXRα, RXRβ and RXRγ respectively), which displays poor binding affinity for RAR isoforms (Ki values are 2746, 3516 and >10,000 nM for RARα, RARβ and RARγ respectively). Learn MoreStarting at: $139.00
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GW 0742
GW 0742 is a potent and highly selective PPARδ agonist. EC50 values are 0.001, 1.1 and 2 μM for transactivation of human PPARδ, -α, and -γ receptors respectively. Learn MoreStarting at: $129.00
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MPP dihydrochloride
MPP dihydrochloride is a selective, high affinity silent antagonist at ERα receptors. Displays > 200-fold selectivity for ERα over ERβ. Ki values are 2.7 and 1800 nM at ERα and ERβ receptors respectively. Learn MoreStarting at: $109.00
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BMS 195614
BMS 195614 is a neutral retinoic acid receptor (RAR) α-selective antagonist (Ki = 2.5 nM) which displays no significant effect on nuclear receptor corepressor (NCoR) binding; moderately decreases SMRT binding to RAR. Learn MoreStarting at: $159.00
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Tesaglitazar
Dual-specificity PPARα/γ agonist (IC50 values are 0.35 and 3.8 μM for PPARγ and PPARα respectively). Learn MoreStarting at: $140.00
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GC 1
GC 1 is a thyromimetic; high affinity agonist at thyroid hormone receptor (TR) β and TRα receptors (KD values are 67 and 440 pM respectively), which displays 5- and 100-fold greater potency than the endogenous agonist T3 in vitro at TRα1 and TRβ1 receptors respectively. Learn MoreStarting at: $115.00
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GW 1929 hydrochloride
GW 1929 hydrochloride is a highly selective orally active peroxisome proliferator-activated receptor (PPAR)γ agonist (pEC50 values are 8.05, < 4 and < 4 for human PPARγ, PPARα and PPARδ receptors respectively). Learn MoreStarting at: $135.00
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Cl-4AS-1
Cl-4AS-1 is a potent steroidal androgen receptor agonist (IC50 = 12 nM), which inhibits 5α-reductase type I and II (IC50 values are 6 and 10 nM respectively). Learn MoreStarting at: $140.00
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ER 50891
ER 50891 is a antagonist of RARα receptors (IC50 = 31.2 nM), which displays selective affinity for RARα (relative IC50 values are 1.8, 432 and 535 nM for RARα, RARγ and RARβ respectively). Learn MoreStarting at: $155.00
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BMS 961
BMS 961 is a selective RARγ agonist (EC50 values are 30 and 1000 nM at RARγ and RARβ respectively). Learn MoreStarting at: $135.00
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DLPC
DLPC is a selective agonist of the orphan nuclear receptor LRH-1 (liver receptor homolog-1, NR5A2) in vitro, which induces bile acid biosynthetic enzymes; increases bile acid and decreases hepatic triglycerides and serum glucose, and exhibits antidiabetic effects. Learn MoreStarting at: $50.00
