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Search results for 'CT 47098'
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Guggulsterone
Guggulsterone is a broad spectrum steroid receptor ligand that binds with high affinity to mineralocorticoid receptors and lower affinity to progesterone, androgen and glucocorticoid receptors. Learn MoreStarting at: $109.00
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DY131
DY131 is a novel selective agonist at estrogen-related receptors ERRβ and ERRγ that displays minimal activity at ERRα, ERα and ERβ at concentrations up to 30 μM. Learn MoreStarting at: $95.00
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SID 7969543
SID 7969543 is a selective steroidogenic factor-1 (SF-1, NR5A1) inhibitor that inhibits SF-1-dependent luciferase expression in HEK 293T cells in vitro with an IC50 value of 30 nM). Learn MoreStarting at: $89.00
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Y 134
Y 134 is a selective estrogen receptor modulator (SERM) that acts as an agonist in the bone and antagonist in reproductive tissue. Learn MoreStarting at: $139.00
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PHTPP
PHTPP is a selective estrogen ERβ receptor antagonist that exhibits full antagonism at ERβ in a cotransfection assay in human endometrial cancer cells (HEC-1), with minimal effects on ERα. Learn MoreStarting at: $145.00
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RU 28318 (potassium salt)
RU 28318 (potassium salt) is a potent and selective antagonist for the mineralocorticoid receptor (MR) that inhibits aldosterone production and secretion, and selectively decreases ex-vivo MR binding in the hippocampus of adrenalectomised rats. Learn MoreStarting at: $139.00
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SR 202
SR 202 is a selective PPARγ antagonist that inhibits PPARγ-dependent adipocyte differentiation and growth in vitro and in vivo. Learn MoreStarting at: $90.00
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TCPOBOP
TCPOBOP is an agonist of the constitutive androstane receptor that induces activity of ER1 cytochrome P450 isozymes, NADPH-cytochrome c reductase, microsomal epoxide hydrolase and glutathione S transferase. Learn MoreStarting at: $79.00
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Ciglitazone
Ciglitazone is a selective agonist at PPAR&gamma with an EC50 value of 3 μM in vivo. Learn MoreStarting at: $139.00
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CP 775146
CP 775146 is a selective, high affinity PPARα agonist with Ki values of 24.5 nM for PPARα and >10 μM for PPARβ and PPARγ in vitro). Learn MoreStarting at: $169.00
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Docosahexaenoic acid
Docosahexaenoic acid is a endogenous omega-3 fatty acid. It acts as a selective retinoid X receptor (RXR) agonist that displays no activity at RAR, thyroid hormone receptor or the vitamin D receptor (VDR). Learn MoreStarting at: $75.00
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AC 55649
AC 55649 is a potent, isoform-selective RARβ2 receptor agonist that displays 100-fold selectivity versus other retinoid receptors. Inhibits proliferation of the breast cancer cell line MCF-7. Learn MoreStarting at: $99.00
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Fexaramine
Fexaramine is a potent, selective farnesoid X receptor agonist with EC50 = 25 nM. Learn MoreStarting at: $155.00
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ERB 041
IC50 values of ERB 041 are 5 and 1216 nM for human ERβ and ERα; 3.1 and 620 nM for rat ERβ and ERα; and 3.7 and 750 nM for mouse ERβ and ERα respectively. Learn MoreStarting at: $139.00
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(R)-DPN
(R)-DPN, a enantiomer of DPN, displays higher affinity for estrogen receptor (ER) β over ERα with Ki values of 1.82 and 147 nM respectively . Learn MoreStarting at: $186.00
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CD 2665
SC 236 is a selective COX-2 inhibitor (IC50 values are 0.005 and 17.8 μM for COX-2 and COX-1 respectively) which displays anti-inflammatory properties and potent antimetastatic activity against both experimental metastases and spontaneous metastases arising following primary tumor excision. Learn MoreStarting at: $140.00
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BADGE
RS 39604 hydrochloride is a potent and selective 5-HT4 antagonist, with a pKi of 9.1 at 5-HT4 receptors in guinea pig striatal membranes and greater than 1000-fold selectivity over 5-HT1A, 2C, 3 and D1, D2, M1, M2, AT1, B1 and α1C receptors. Learn MoreStarting at: $80.00
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BMS 453
R-96544 hydrochloride is a potent, selective 5-HT2 receptor antagonist which displays some selectivity for 5-HT2A receptors (Ki = 1.6 nM) and inhibits 5-HT-induced platelet aggregation and pressor responses in vivo. Learn MoreStarting at: $135.00
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Corticosterone
Corticosterone is an endogenous glucocorticoid that acts as an agonist at glucocorticoid and mineralocorticoid receptors. Learn MoreStarting at: $85.00
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ITE
ITE is an endogenous agonist for the transcription factor aryl hydrocarbon receptor (AHR); Ki = 3 nM for binding to murine AHR. Learn MoreStarting at: $139.00
