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Search results for 'inhibit'
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ML 298 hydrochloride
ML 298 hydrochloride is a selective inhibitor of phospholipase D2 (PLD2) (IC50 values are 355 and >20,000 nM for PLD2 and PLD1, respectively), which decreases invasive migration in U87-MG glioblastoma cells, without affecting cell viability. Learn MoreStarting at: $125.00
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L-651,582
L-651,582 is an orally active Ca2+ channel blocker which inhibits K+- and carbachol-stimulated Ca2+ influx (IC50 values are 500 and 935 nM respectively). Learn MoreStarting at: $149.00
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AMTB hydrochloride
AMTB hydrochloride is a TRPM8 channel blocker that inhibits icilin- induced TRPM8 channel activation in a rat model. Learn MoreStarting at: $139.00
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Zatebradine hydrochloride
Zatebradine hydrochloride is a bradycardic agent that produces use-dependent inhibition of hyperpolarization-activated current If (HCN channel) in sinoatrial node cells and Purkinje fibres. Learn MoreStarting at: $109.00
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Benidipine hydrochloride
Benidipine hydrochloride is an orally active antihypertensive agent that inhibits L-, N- and T-type Ca2+ channels and also inhibits aldosterone-induced mineralocorticoid receptor activation. Learn MoreStarting at: $109.00
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HC 067047
HC 067047 is a potent and selective TRPV4 antagonist that reversibly inhibits currents through mouse, human and rat TRPV4 orthologs. Learn MoreStarting at: $139.00
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6-Iodonordihydrocapsaicin
6-Iodonordihydrocapsaicin is a potent competitive vanilloid TRPV1 (VR1) receptor antagonist that inhibits capsaicin-induced [Ca2+]i increase in rat DRG neurons, and guinea pig bladder and trachea contractions in vitro. Learn MoreStarting at: $115.00
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Mirtazapine
Mirtazapine is an antidepressant agent that enhances noradrenalin (NA) release in rat brain via inhibition of α2-adrenergic autoreceptors and displays only weak affinity for monoamine transporters. Learn MoreStarting at: $85.00
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DCPIB
DCPIB is a potent, selective blocker of the volume-sensitive anion channel (VSAC) that reverses cell swelling-induced action potential duration shortening in atrial myocytes and inhibits astroglial swelling in vitro. Learn MoreStarting at: $109.00
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A 784168
A 784168 is a potent TRPV1 antagonist with an IC50 value of 25 nM for inhibition of TRPV1 activation by 50 nM capsaicin. Learn MoreStarting at: $139.00
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JNJ 17203212
JNJ 17203212 is a reversible, competitive and potent TRPV1 antagonist that inhibits capsaicin- and H+-induced channel activation and exhibits antitussive and analgesic activity in vivo. Learn MoreStarting at: $119.00
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MG 624
MG 624 inhibits α-Bgtx binding to chick α7 and α4β2 subtypes with Ki values of 106 nM and 84 μM respectively. Learn MoreStarting at: $99.00
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Bepridil hydrochloride
Bepridil hydrochloride is a calcium channel blocker that inhibits Na+/Ca2+ exchange (NCX), sodium channels and cardiac sarcolemmal KATP channels. Learn MoreStarting at: $75.00
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9-AC
9-AC is a Cl- transport inhibitor with a moderate to strong inhibitory action on PKA activated cardiac IcI. Learn MoreStarting at: $65.00
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Nonactin
Nonactin is a monovalent cation ionophore that displays selectivity for K+ and NH4+. It also inhibits P-glycoprotein-mediated efflux of chemotherapeutic agents in multiple-drug resistant cancer cells. Learn MoreStarting at: $99.00
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TNP-ATP triethylammonium salt
TNP-ATP triethylammonium salt is a high affinity, selective P2X receptor antagonist that inhibits ATP-induced currents in cells expressing P2X1, P2X3 and heteromeric P2X2/3 receptors with IC50 values of 6, 0.9 and 7 nM respectively. Learn MoreStarting at: $189.00
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PNU 37883 hydrochloride
PNU 37883 hydrochloride acts as a novel antagonist selective for the vascular form of Kir6 (KATP) channel. It inhibits Kir6 currents in isolated mesenteric artery smooth muscle cells (Kd = 65 nM) but not in cardiac or skeletal myocytes. Learn MoreStarting at: $125.00
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L-Serine
L-Serine is an endogenous agonist at the inhibitory glycine receptor. Learn MoreStarting at: $33.00
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L-Alanine
L-Alanine is an Agonist at the inhibitory glycine receptor. Learn MoreStarting at: $33.00
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T16Ainh-A01
T16Ainh-A01 is an inhibitor of Ca2+-dependent Cl- channel (CaCC) transmembrane protein 16A (TMEM16A) (IC50 = 1.8 μM in A253 salivary gland epithelial cells). Learn MoreStarting at: $119.00
