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ML 298 hydrochloride
ML 298 hydrochloride is a selective inhibitor of phospholipase D2 (PLD2) (IC50 values are 355 and >20,000 nM for PLD2 and PLD1, respectively), which decreases invasive migration in U87-MG glioblastoma cells, without affecting cell viability. Learn MoreStarting at: $125.00
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(R)-(+)-Bay K 8644
(R)-(+)-Bay K 8644 is a L-type Ca2+-channel blocker with negative inotropic and vasodilatatory effects in vivo. Learn MoreStarting at: $189.00
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(S)-(-)-Bay K 8644
(S)-(-)-Bay K 8644 is a L-type Ca2+-channel activator with positive inotropic, vasoconstrictive and behavioral effects in vivo. Learn MoreStarting at: $199.00
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NS 11021
NS 11021 is an activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1). Learn MoreStarting at: $139.00
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ATPγS tetralithium salt
ATPγS tetralithium salt is a P2 purinergic receptor agonist. Learn MoreStarting at: $139.00
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6-Iodonordihydrocapsaicin
6-Iodonordihydrocapsaicin is a potent competitive vanilloid TRPV1 (VR1) receptor antagonist that inhibits capsaicin-induced [Ca2+]i increase in rat DRG neurons, and guinea pig bladder and trachea contractions in vitro. Learn MoreStarting at: $115.00
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Mirtazapine
Mirtazapine is an antidepressant agent that enhances noradrenalin (NA) release in rat brain via inhibition of α2-adrenergic autoreceptors and displays only weak affinity for monoamine transporters. Learn MoreStarting at: $85.00
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MNI-caged-D-aspartate
MNI-caged-D-aspartate is a D-aspartate caged with the photosensitive 4-methoxy-7-nitroindolinyl group. Learn MoreStarting at: $149.00
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DCPIB
DCPIB is a potent, selective blocker of the volume-sensitive anion channel (VSAC) that reverses cell swelling-induced action potential duration shortening in atrial myocytes and inhibits astroglial swelling in vitro. Learn MoreStarting at: $109.00
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KM 11060
KM 11060 increases the amount of functional CFTR at the plasma membrane (~75%). Learn MoreStarting at: $105.00
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N20C hydrochloride
N20C hydrochloride is a selective, non-competitive NMDA receptor antagonist that binds to the receptor-associated ion channel and prevents glutamate-induced Ca2+ influx. Learn MoreStarting at: $99.00
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Cesium chloride
Cesium chloride is a potassium channel blocker that prevents activation of caspase-3 and neuronal apoptosis in serum- and potassium-deprived cerebellar granule neurons by inactivating GSK-3β. Learn MoreStarting at: $39.00
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4-Acetyl-1,1-dimethylpiperazinium iodide
4-Acetyl-1,1-dimethylpiperazinium iodide is a structural analog of acetylcholine that acts as a nicotinic agonist with a Ki value of 29.9 nM at α4β2. Learn MoreStarting at: $89.00
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Veratridine
Veratridine is a Voltage-gated Na+ channel opener that increases intracellular Ca2+ with no effect on the Na+/Ca2+ exchanger. Learn MoreStarting at: $79.00
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Chlorisondamine diiodide
Chlorisondamine diiodide is an exceptionally long lasting nicotinic antagonist with IC50 value of ~1.6 mM. Learn MoreStarting at: $99.00
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WS 12
WS 12 is a potent TRPM8 agonist that acts as a cooling agent with EC50 value of 193 nM. Learn MoreStarting at: $99.00
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(±)-Anatoxin A fumarate
(±)-Anatoxin A fumarate is a potent nicotinic agonist that stimulates [3H]-dopamine release from rat striatal synaptosomes with EC50 value of 136 nM. Learn MoreStarting at: $139.00
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1-Acetyl-4-methylpiperazine hydrochloride
1-Acetyl-4-methylpiperazine hydrochloride is a structural analog of acetylcholine that acts as a nAChR agonist. Learn MoreStarting at: $96.00
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AZ 10606120 dihydrochloride
AZ 10606120 dihydrochloride is a potent P2X7 receptor antagonist that binds in a positive cooperative manner to sites distinct from, but coupled to, the ATP binding site and acts as a negative allosteric modulator. Learn MoreStarting at: $121.00
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DCEBIO
DCEBIO stimulates Cl- secretion via the activation of hKCa3.1 (IK1) potassium channels and an apical Cl- conductance carried by the CFTR channel. Learn MoreStarting at: $99.00
