Search results for 'PR 171'
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3-pyr-Cytisine
3-pyr-Cytisine is a high affinity α4β2 partial agonist that exhibits antidepressant-like effects in mouse models of antidepressant efficacy. Learn MoreStarting at: $139.00
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Levcromakalim
Levcromakalim is an active enantiomer of the prototypical Kir6 (KATP) channel opener cromakalim. Learn MoreStarting at: $169.00
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Cromakalim
Cromakalim is a prototypical Kir6 (KATP) channel opener that relaxes rabbit isolated portal vein with an IC50 value of 21 nM . Learn MoreStarting at: $139.00
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Zatebradine hydrochloride
Zatebradine hydrochloride is a bradycardic agent that produces use-dependent inhibition of hyperpolarization-activated current If (HCN channel) in sinoatrial node cells and Purkinje fibres. Learn MoreStarting at: $109.00
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UCL 2077
UCL 2077 is a slow afterhyperpolarization (sAHP) channel blocker that reduces sAHP in hippocampal slice preparations. Learn MoreStarting at: $105.00
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Zacopride hydrochloride
Zacopride hydrochloride is a highly potent 5-HT3 receptor antagonist and 5-HT4 receptor agonist with Ki values of 0.38nM and 373nM respectively. Learn MoreStarting at: $105.00
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6-Iodonordihydrocapsaicin
6-Iodonordihydrocapsaicin is a potent competitive vanilloid TRPV1 (VR1) receptor antagonist that inhibits capsaicin-induced [Ca2+]i increase in rat DRG neurons, and guinea pig bladder and trachea contractions in vitro. Learn MoreStarting at: $115.00
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Mirtazapine
Mirtazapine is an antidepressant agent that enhances noradrenalin (NA) release in rat brain via inhibition of α2-adrenergic autoreceptors and displays only weak affinity for monoamine transporters. Learn MoreStarting at: $85.00
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Mecamylamine hydrochloride
Mecamylamine hydrochloride is a non-competitive nicotinic acetylcholine receptor antagonist that displays antidepressant-like effects in mice. Learn MoreStarting at: $75.00
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N20C hydrochloride
N20C hydrochloride is a selective, non-competitive NMDA receptor antagonist that binds to the receptor-associated ion channel and prevents glutamate-induced Ca2+ influx. Learn MoreStarting at: $99.00
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Cesium chloride
Cesium chloride is a potassium channel blocker that prevents activation of caspase-3 and neuronal apoptosis in serum- and potassium-deprived cerebellar granule neurons by inactivating GSK-3β. Learn MoreStarting at: $39.00
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threo Ifenprodil hemitartrate
threo Ifenprodil hemitartrate is a potent σ receptor agonist and NR2B subunit-selective NMDA receptor antagonist. Learn MoreStarting at: $109.00
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Piracetam
Piracetam is a nootropic that displays cognitive enhancing properties.It facilitates efficiency of cholinergic neurotransmission at muscarinic receptors. Learn MoreStarting at: $55.00
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Bepridil hydrochloride
Bepridil hydrochloride is a calcium channel blocker that inhibits Na+/Ca2+ exchange (NCX), sodium channels and cardiac sarcolemmal KATP channels. Learn MoreStarting at: $75.00
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(RS)-AMPA
(RS)-AMPA is a prototypical and defining agonist for the AMPA subgroup of ionotropic glutamate receptors. Learn MoreStarting at: $139.00
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Psora 4
Psora 4 is a potent KV1.3 channel blocker (EC50 = 3 nM) that preferentially binds the C-type inactivated state of the channel. Learn MoreStarting at: $145.00
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PPDA
PPDA is a subtype-selective NMDA receptor antagonist that preferentially binds to NR2C/NR2D-containing receptors. Learn MoreStarting at: $119.00
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Nonactin
Nonactin is a monovalent cation ionophore that displays selectivity for K+ and NH4+. It also inhibits P-glycoprotein-mediated efflux of chemotherapeutic agents in multiple-drug resistant cancer cells. Learn MoreStarting at: $99.00
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Dextromethorphan hydrobromide
Dextromethorphan hydrobromide is a Non-competitive, low affinity NMDA receptor antagonist with the effect of antitussive, anticonvulsive and neuroprotective. Learn MoreStarting at: $42.00
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TNP-ATP triethylammonium salt
TNP-ATP triethylammonium salt is a high affinity, selective P2X receptor antagonist that inhibits ATP-induced currents in cells expressing P2X1, P2X3 and heteromeric P2X2/3 receptors with IC50 values of 6, 0.9 and 7 nM respectively. Learn MoreStarting at: $189.00