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NS 11021
NS 11021 is an activator of large-conductance Ca2+-activated potassium channels (BKCa, KCa1.1). Learn MoreStarting at: $139.00
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A 844606
A 844606 is a selective α7 nicotinic acetylcholine receptor (nAChR) agonist with EC50 values of 1.4 and 2.2 μM at human and rat receptors respectively. Learn MoreStarting at: $129.00
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Psora 4
Psora 4 is a potent KV1.3 channel blocker (EC50 = 3 nM) that preferentially binds the C-type inactivated state of the channel. Learn MoreStarting at: $145.00
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NS 3763
NS 3763 is a selective non-competitive kainate receptor antagonist that displays selectivity for GLUK5 subunit-containing receptors with IC50 values of 1.6 and > 30 μM for homomeric GLUK5 and GLUK6 receptors respectively. Learn MoreStarting at: $99.00
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Chlorisondamine diiodide
Chlorisondamine diiodide is an exceptionally long lasting nicotinic antagonist with IC50 value of ~1.6 mM. Learn MoreStarting at: $99.00
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T16Ainh-A01
T16Ainh-A01 is an inhibitor of Ca2+-dependent Cl- channel (CaCC) transmembrane protein 16A (TMEM16A) (IC50 = 1.8 μM in A253 salivary gland epithelial cells). Learn MoreStarting at: $119.00
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MRS 1845
MRS 1845 is potent blocker of store-operated Ca2+ channels and inhibits capacitative Ca2+ influx in HL-60 cells (IC50 = 1.7 mM). Learn MoreStarting at: $120.00
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ZK 200775
Benzamil is a Na+/Ca2+ exhanger (NCX) inhibitor (IC50 ~ 100 nM); TRPP3 channel blocker (IC50 = 1.1 μM for inhibition of Ca2+-activated TRPP3 channel activity). Learn MoreStarting at: $140.00
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4-Aminopyridine
4-Aminopyridine is a non-selective voltage-dependent K+-channel blocker (IC50 values are 170 and 230 μM at KV1.1 and KV1.2 respectively). Learn MoreStarting at: $55.00
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α-Spinasterol
α-Spinasterol is a TRPV1 antagonist (IC50 = 1.4 μM), which reduces capsaicin-mediated Ca2+ influx in vitro; displays antinociceptive and antiedematogenic effects in multiple mouse models of pain. Learn MoreStarting at: $89.00
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NS 1643
NS 1643 is a human ether-a-go-go related gene (hERG) KV11.1 channel activator (EC50 = 10.5 μM), which exhibits different molecular mechanisms of action at KV11.1 (hERG1) and KV11.2 (hERG2) channels. Learn MoreStarting at: $90.00
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DPO-1
DPO-1 is a blocker of IKur ultrarapid delayed rectifier potassium current and KV1.5 channels (IC50 = 0.31 μM for rKV1.5), which displays selectivity for inhibition of IKur over Ito (8-fold), IK1, IKr and IKs (20-fold) in native myocytes and selectivity for rat recombinant KV1.5 over KV3.1 (~ 15-fold). Learn MoreStarting at: $105.00
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NS 5806
NS 5806 is a KV4.3 channel activator; mediates the transient outward K+ current (Ito), which increases IKv4.3 peak current amplitude in CHO-K1 cells expressing KV4.3 and KChIP2 (EC50 = 5.3 μM), and inhibits KV1.4-mediated currents independently of KChIP2. Learn MoreStarting at: $149.00
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NS 6180
NS 6180 is a potent KCa3.1 channel blocker (IC50 values are 9, 14 and 15 nM for rat, human and mouse erythrocyte KCa3.1 channels respectively), which exhibits ~ 50% inhibition of KCa1.1, KV1.3, and KV11.1 channels, noradrenaline and dopamine transporters, L-type Ca2+ channels and melatonin receptors at a concentration of 10 μM. Learn MoreStarting at: $99.00
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NS 3623
NS 3623 is a human ether-a-go-go (hERG) KV11.1 potassium channel activator, which activates the IKr current and displays antiarrhythmic activity and exhibits potential dual mode of action at the hERG inhibitory site; may also act as a partial blocker of KV11.1 (hERG) channels. Learn MoreStarting at: $145.00
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6'-Iodoresiniferatoxin
6'-Iodoresiniferatoxin is a high affinity TRPV1 (VR1) vanilloid receptor partial agonist (Ki = 0.71 nM; EC50 = 130 nM at human VR1), which displays partial agonism at human VR1 and full agonism at rat VR1. Learn MoreStarting at: $159.00
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Spermidine trihydrochloride
Spermidine trihydrochloride binds to the polyamine modulatory site of the NMDA receptor and has been described as an agonist based on its ability to enhance the binding of [3H]-MK801. Learn MoreStarting at: $65.00
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PD 118057
PD 118057 is a human ether-a-go-go (hERG) KV11.1 potassium channel activator, which displays no major effect on INa, ICa/L, IK1 and IKs currents. Learn MoreStarting at: $119.00
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VU 590 dihydrochloride
VU 590 dihydrochloride is an inhibits the renal outer medullary potassium channel (Kir1.1, ROMK) (IC50 = 294 nM), which also inhibits the inward retifying K+ channel Kir7.1; displays no effect upon Kir2.1 or Kir4.1. Learn MoreStarting at: $85.00
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Ambroxol hydrochloride
Ambroxol hydrochloride is a sodium channel blocker and mucolytic agent with antioxidant, anti-viral and anti-inflammatory properties, which inhibits tetrodotoxin (TTX)-resistant channels more potently than TTX-sensitive subtypes (IC50 values for tonic block are 35.2 and 111.5 μM respectively). Learn MoreStarting at: $69.00
