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Search results for 'AP 24534'
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Ruthenium Red
Ruthenium Red Blocks Ca2+ uptake and release from mitochondria, and Ca2+ release from ryanodine-sensitive intracellular stores. Also blocks cell membrane-located capsaicin-activated cation channels (IC50 = 14 nM) and voltage-sensitive Ca2+ channels to inhibit neurotransmitter release. Learn MoreStarting at: $65.00
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A 804598
A 804598 is a potent, competitive P2X7 receptor antagonist (IC50 values are 8.9, 9.9 and 10.9 nM for mouse, rat and human P2X7 receptors respectively), which binds with high affinity (Ki app = 2.4 nM for rat P2X7 receptors). Learn MoreStarting at: $100.00
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Naspm trihydrochloride
Naspm trihydrochloride is a selective antagonist of Ca2+-permeable AMPA receptors, which blocks AMPA receptors lacking the GluR2 subunit, and protects hippocampal neurons against global ischemia-induced cell death. Learn MoreStarting at: $140.00
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Ibutilide hemifumarate
Ibutilide hemifumarate is a class III antiarrhythmic which blocks the rapid component of delayed rectifier K+ current (IKr), hERG channels and L-type Ca2+ channels. Learn MoreStarting at: $85.00
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DL-AP4 Sodium salt
DL-AP4 Sodium salt is a sodium salt of the broad spectrum EAA ligand DL-AP4 . Learn MoreStarting at: $65.00
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DL-AP5 Sodium salt
DL-AP5 Sodium salt is a sodium salt of DL-AP5. Potent NMDA antagonist. Learn MoreStarting at: $69.00
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(RS)-(Tetrazol-5-yl)glycine
(RS)-(Tetrazol-5-yl)glycine is a potent NMDA receptor agonist, approximately 20 times more active than NMDA. Learn MoreStarting at: $140.00
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MR 16728 hydrochloride
This analog of cetiedil stimulates the release of acetylcholine from synaptosomes. Learn MoreStarting at: $105.00
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PPAHV
PPAHV is a non-pungent vanilloid TRPV1 (VR1) receptor agonist (Ki = 3.1 μM) that displays non-cooperative binding and induces apoptosis via a non-VR1 mechanism in Jurkat cells and causes vasoconstriction in vivo. Learn MoreStarting at: $98.00
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UCL 1684
UCL 1684 is a highly potent, non-peptidic blocker of the apamin-sensitive Ca2+-activated K+ channel (KCa2.1) (IC50 = 3 nM in rat sympathetic neurons) which blocks hKCa2.1 and rKCa2.2 channels expressed in HEK 293 cells with IC50 values of 762 and 364 pM respectively. Learn MoreStarting at: $119.00
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Valinomycin
Valinomycin is a selective K+ ionophore (K0.5 values are 48, 73, 75, 93 and 246 mM for K+, Rb+, Cs+, Na+ and Li+ respectively) that transports K+ across biological and artificial lipid membranes, which inhibits Ca2+-ATPase activity and induces apoptosis through mitochondrial membrane depolarization, caspase-3 activation and phosphatidylserine translocation in vitro. Learn MoreStarting at: $50.00
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DL-AP4
DL-AP4 is a broad spectrum EAA ligand. Learn MoreStarting at: $65.00
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Ralfinamide mesylate
Ralfinamide mesylate is a sodium channel blocker, which suppresses tetrodotoxin (TTX)-resistant Na+ currents approximately twice as selectively as TTX-sensitive currents. Learn MoreStarting at: $65.00
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5-Iodo-A-85380 dihydrochloride
5-Iodo-A-85380 dihydrochloride is a highly potent and subtype-selective agonist for the α4β2 and α6β2 nicotinic acetylcholine receptors, which activates α-CTx-MII-sensitive and -insensitive components of [3H]dopamine release from rat striatal synaptosomes, corresponding to α6β2 and α4β2 (EC50 values are 12.7 and ~35 nM respectively). ~5000- , 25000- and 140000-fold selective over α3β4, α7 and muscle nAChR receptors respectively. Learn MoreStarting at: $195.00
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YM 58483
YM 58483 is a blocker of store-operated Ca2+ entry (SOCE), which mediates the activation of non-excitable cells (e.g. lymphocytes) and inhibits calcium release-activated calcium (CRAC) channels; suppresses thapsigargin-induced sustained Ca2+ influx (IC50 = 100 nM). Learn MoreStarting at: $145.00
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Licarbazepine
Licarbazepine is an active metabolite of oxcarbazepine which produces dose-dependent inhibition of glutamatergic excitatory postsynaptic potentials (EPSPs). Learn MoreStarting at: $85.00
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MNI-caged-L-glutamate
MNI-caged-L-glutamate is a MNI-caged glutamate that rapidly and efficiently releases glutamate when photolysed (300 - 380 nm excitation). Learn MoreStarting at: $139.00
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BCTC
BCTC is an orally effective vanilloid receptor 1 (TRPV1 receptor) antagonist, which inhibits acid- and capsaicin-induced activation of rat TRPV1 receptors (IC50 values are 6.0 and 35 nM respectively). Learn MoreStarting at: $109.00
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DPO-1
DPO-1 is a blocker of IKur ultrarapid delayed rectifier potassium current and KV1.5 channels (IC50 = 0.31 μM for rKV1.5), which displays selectivity for inhibition of IKur over Ito (8-fold), IK1, IKr and IKs (20-fold) in native myocytes and selectivity for rat recombinant KV1.5 over KV3.1 (~ 15-fold). Learn MoreStarting at: $105.00
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SB 452533
SB 452533 is a potent TRPV1 antagonist against capsaicin (pKb = 7.7), noxious heat and acid-mediated (pIC50 = 7.0) receptor activation (pKi = 6.22 at the recombinant hTRPV1 receptor). Learn MoreStarting at: $109.00
