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Search results for 'inhibit'
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RuBi GABA trimethylphosphine
RuBi GABA trimethylphosphine is a modified version of RuBi-GABA, which suppresses cortical local field potential (LFP) activity in anesthetized mice after activation with a blue laser pulse and inhibits neural activity. Learn MoreStarting at: $159.00
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CGK 733
CGK 733 is originally defined as a selective inhibitor of ATR and ATM kinases that decreases p21CIP1 levels in premature senescent MCF-7 and HCT-116 cells. Learn MoreStarting at: $105.00
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AT 101
AT101, a natural product from cottonseed with a BH3-mimetic structure, was identified as a small molecule inhibitor of Bcl-2/Bcl-xL/Mcl-1 that potently induces apoptosis in various cancer cell lines. Learn MoreStarting at: $105.00
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Ivachtin
Ivachtin is a potent, reversible inhibitor of caspase-3 that exhibits antiapoptotic activity in human Jurkat T cells treated with staurosporine and also a higher level of protection than Z-VAD-FMK. Learn MoreStarting at: $85.00
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Chloroquine diphosphate
Chloroquine diphosphate is an antimalarial drug, which inhibits cell growth and induces cell death in numerous cancer cell lines; inhibits cell proliferation and viability and induces apoptosis in 4T1 mouse breast cancer cells in vitro. Learn MoreStarting at: $59.00
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SJ 172550
SJ 172550 is a MDMX inhibitor, which reversibly binds MDMX (EC50 = 2.3 μM), and inhibits the MDMX-p53 interaction in cultured retinoblastoma cells; frees p53 to induce apoptosis. Learn MoreStarting at: $119.00
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iMAC2
iMAC2 is an inhibitor of mitochondrial apoptosis-induced channel (MAC) (IC50 = 28 nM), which reduces STS-induced apoptosis in FL5.12 cells by over 50% and inhibits release of cytochrome c by Bid-induced Bax activation (IC50 = 0.68 μM). Learn MoreStarting at: $149.00
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Bax channel blocker
Bax channel blocker is a potent inhibitor of Bax-mediated mitochondrial cytochrome c release (IC50 = 0.52 μM). Learn MoreStarting at: $119.00
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AZ 10417808
AZ 10417808 is a selective non-peptide inhibitor of caspase-3 (Ki = 247 nM); displays > 40-fold selectivity over caspases 1, 2, 6, 7 and 8 (Ki > 10 μM). Completely blocks staurosporine-induced intracellular DEVDase activity in SH-SY5Y cells (IC50 = 14.9 μM). Learn MoreStarting at: $139.00
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CHM 1
CHM 1 is an inducer of apoptosis; displays potent antitumor ability in human hepatocellular carcinoma which inhibits tubulin polymerization in vitro and in vivo. Causes cell cycle arrest at G2/M phase by activation of Cdc2 kinase activity. Learn MoreStarting at: $100.00
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Melphalan
Melphalan is a DNA alkylating agent; induces cytotoxicity through the formation of stable interstrand and intrastrand crosslinks within DNA which inhibits growth of PC-3 cells (IC50 values are 0.074 and 0.77 μM for sequential dosing and single dosing respectively). Learn MoreStarting at: $65.00
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CP 31398 dihydrochloride
CP 31398 dihydrochloride is a p53 stabilizing agent, which stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53 and inhibits growth of small human tumor xenografts in vivo. Learn MoreStarting at: $90.00
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RETRA hydrochloride
RETRA hydrochloride is an antitumor agent, that inhibits tumor cell growth in a mutant p53- and p73-dependent manner in vitro and in vivo (IC50 = 4 μM). Learn MoreStarting at: $95.00
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PETCM
PETCM is a caspase-3 activator, and acts via inhibition of the oncoprotein ProT. Learn MoreStarting at: $145.00
