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Search results for 'CT 47098'
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RuBi GABA trimethylphosphine
RuBi GABA trimethylphosphine is a modified version of RuBi-GABA, which suppresses cortical local field potential (LFP) activity in anesthetized mice after activation with a blue laser pulse and inhibits neural activity. Learn MoreStarting at: $159.00
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CGK 733
CGK 733 is originally defined as a selective inhibitor of ATR and ATM kinases that decreases p21CIP1 levels in premature senescent MCF-7 and HCT-116 cells. Learn MoreStarting at: $105.00
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AT 101
AT101, a natural product from cottonseed with a BH3-mimetic structure, was identified as a small molecule inhibitor of Bcl-2/Bcl-xL/Mcl-1 that potently induces apoptosis in various cancer cell lines. Learn MoreStarting at: $105.00
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PhiKan 083
PhiKan 083 is a p53 stabilizing agent that binds mutated (Y220C) p53 over wild-type p53 at a site distinct from functional DNA/protein interaction regions. Learn MoreStarting at: $125.00
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Ivachtin
Ivachtin is a potent, reversible inhibitor of caspase-3 that exhibits antiapoptotic activity in human Jurkat T cells treated with staurosporine and also a higher level of protection than Z-VAD-FMK. Learn MoreStarting at: $85.00
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MIRA-1
MIRA-1 is a Restores wild-type conformation, function and DNA binding activity to mutant p53 that induces p53 transcriptional transactivation of p21, MDM2 and PUMA, and promotes tumor cell death by apoptosis in a mutant p53-dependent manner in vitro (IC50 = 10μM). Learn MoreStarting at: $89.00
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NSC 146109 hydrochloride
NSC 146109 hydrochloride is cell-permeable, genotype-selective antitumor agent that increases levels of endogenous p53 in tumor cells and protects p53 from Mdm2-mediated degradation. Learn MoreStarting at: $109.00
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SJ 172550
SJ 172550 is a MDMX inhibitor, which reversibly binds MDMX (EC50 = 2.3 μM), and inhibits the MDMX-p53 interaction in cultured retinoblastoma cells; frees p53 to induce apoptosis. Learn MoreStarting at: $119.00
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2,3-DCPE hydrochloride
2,3-DCPE hydrochloride selectively induces apoptosis and downregulates Bcl-XL protein expression in various human cancer cells versus normal cells in vitro. IC50 values are 0.89 and 12.6 μM for LoVo human colon cancer cell line and normal human fibroblasts respectively. Learn MoreStarting at: $75.00
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Muristerone A
Muristerone A is an ecdysone analog that acts as an inducer of ecdysone-inducible gene expression systems in mammalian cells and transgenic animals. Learn MoreStarting at: $139.00
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iMAC2
iMAC2 is an inhibitor of mitochondrial apoptosis-induced channel (MAC) (IC50 = 28 nM), which reduces STS-induced apoptosis in FL5.12 cells by over 50% and inhibits release of cytochrome c by Bid-induced Bax activation (IC50 = 0.68 μM). Learn MoreStarting at: $149.00
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AZ 10417808
AZ 10417808 is a selective non-peptide inhibitor of caspase-3 (Ki = 247 nM); displays > 40-fold selectivity over caspases 1, 2, 6, 7 and 8 (Ki > 10 μM). Completely blocks staurosporine-induced intracellular DEVDase activity in SH-SY5Y cells (IC50 = 14.9 μM). Learn MoreStarting at: $139.00
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CHM 1
CHM 1 is an inducer of apoptosis; displays potent antitumor ability in human hepatocellular carcinoma which inhibits tubulin polymerization in vitro and in vivo. Causes cell cycle arrest at G2/M phase by activation of Cdc2 kinase activity. Learn MoreStarting at: $100.00
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Melphalan
Melphalan is a DNA alkylating agent; induces cytotoxicity through the formation of stable interstrand and intrastrand crosslinks within DNA which inhibits growth of PC-3 cells (IC50 values are 0.074 and 0.77 μM for sequential dosing and single dosing respectively). Learn MoreStarting at: $65.00
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WR 1065
WR 1065 is a cell-permeable reactive oxygen species scavenger that activates p53 through a JNK-dependent signaling pathway, which induces cell cycle arrest and exhibits cytoprotective activity towards normal cells but not cancer cells in vivo. Learn MoreStarting at: $55.00
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CP 31398 dihydrochloride
CP 31398 dihydrochloride is a p53 stabilizing agent, which stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53 and inhibits growth of small human tumor xenografts in vivo. Learn MoreStarting at: $90.00
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PETCM
PETCM is a caspase-3 activator, and acts via inhibition of the oncoprotein ProT. Learn MoreStarting at: $145.00
