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Search results for 'AP 24534'
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MSOP
MSOP is a selective group III metabotropic glutamate receptor antagonist that displays an apparent KDof 51 μM for the L-AP4-sensitive presynaptic mGluR on primary afferent terminals in spinal cord compared to > 700 μM for the (1S,3S)-ACPD-sensitive presynaptic mGlu in the same system. Learn MoreStarting at: $138.00
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(RS)-APICA
PNU 96415E is antipsychotic agent which displays high affinity for dopamine D4 and serotonergic 5-HT2A receptors and relatively weak affinity at D2 receptors (Ki values are 3.0, 5.8, 134, 181, 199, 240, 411 and > 678 nM for D4, 5-HT2A, 5-HT1A, α1, D2, D3, D1, α2 and muscarinic receptors respectively). Learn MoreStarting at: $105.00
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E4CPG
(RS)-APICA is a rigidified analog of MPPG; selective group II metabotropic glutamate receptor antagonist (IC50 = 30 μM) with no significant effect on group I and III mGlu receptors at concentrations up to 1 mM. Learn MoreStarting at: $95.00
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MSPG
MPPG is a potent antagonist of L-AP4-induced effects in rat spinal cord, thalamic and hippocampal neurons, showing selectivity over (1S,3S)-ACPD-induced effects. Potent antagonist of mGlu receptors linked to adenylyl cyclase in adult rat cortical slices. Learn MoreStarting at: $135.00
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(2R,4R)-APDC
MSPG is a selatively non-selective antagonist of presynaptic mGlu receptors in neonatal rat spinal cord and adult rat cerebrocortical mGlu receptors. Learn MoreStarting at: $165.00
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MAP4
(S)-SNAP 5114 is a GABA transport inhibitor, showing selectivity for GAT-3 and GAT-2 (IC50 values are 5, 21 and 388 μM for hGAT-3, rGAT-2 and hGAT-1 respectively). Learn MoreStarting at: $135.00
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O-Phospho-L-serine
O-Phospho-L-serine is a group III metabotropic glutamate receptor agonist; analog of L-AP4, which inhibits proliferation and enhances neuronal differentiation in progenitor cells. Learn MoreStarting at: $59.00
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UBP1112
UBP1112 is a selective group III mGlu receptor antagonist (apparent Kd values are 5.1 and 488 μM for group III and group II mGlu receptors respectively; IC50 > 1 mM for group I, NMDA, AMPA and kainate receptors). Learn MoreStarting at: $139.00
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L-AP4
L-AP4 is a selective group III metabotropic glutamate receptor agonist. Synaptic depressant. Agonist at the quisqualate-sensitized AP6 site in hippocampus. Learn MoreStarting at: $60.00
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DL-AP3
DL-AP3 is a competitive group I metabotropic glutamate receptor antagonist and inhibitor of phosphoserine phosphatase. Learn MoreStarting at: $75.00
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CPPG
CPPG is a potent group II/III mGlu receptor antagonist, with approximately 20-fold selectivity for group III over group II (IC50 values of 2.2 and 46.2 nM respectively). Learn MoreStarting at: $115.00
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EGLU
EGLU is a selective antagonist of presynaptically-mediated (1S,3S)-ACPD-induced depression of motoneuron excitation in neonatal rat spinal cord; presumed group II mGlu receptor antagonist. Learn MoreStarting at: $110.00
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DCG IV
DCG IV is a presynaptic depressant; highly potent agonist for group II mGlu receptors. Learn MoreStarting at: $135.00
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(RS)-PPG
(RS)-PPG is a potent and selective group III metabotropic glutamate receptor agonist, with approximately 25-fold preference for hmGlu8. Learn MoreStarting at: $100.00
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Z-Cyclopentyl-AP4
Z-Cyclopentyl-AP4 is a group III mGlu receptor agonist that exhibits higher potency at mGlu4 than mGlu8 (EC50 values are 49 and 124 μM respectively) with no activity at mGlu7. And selectively inhibits synaptic activity in the lateral perforant pathway (IC50 values are 130 and 1859 μM in the lateral and medial perforant pathways respectively). Learn MoreStarting at: $129.00
