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  • IDE 2

    IDE 2

    IDE 2 is a cell-permeable inducer of definitive endoderm formation in mouse and human embryonic stem cells (ESCs) (EC50 = 223 nM for induction of Sox17 expression in ESCs). It has been reported to activate TGF-β signaling and downstream Smad2 phosphorylation; upregulates Nodal expression. Learn More

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