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CCG 50014
CCG 50014 is a potent and selective inhibitor of regulator of G-protein signaling 4 (RGS4) protein that exhibits >20-fold selectivity for RGS4 over other RGS proteins. Learn MoreStarting at: $125.00
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MDL 28170
MDL 28170 is a potent, selective inhibitor of calpain and cathepsin B that rapidly penetrates the blood-brain barrier following systemic administration and displays neuroprotective effects in vivo. Learn MoreStarting at: $65.00
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Leptomycin B
Leptomycin B, an antifungal antibiotic, is an inhibitor of the nuclear export of proteins that inhibits the nuclear export of the HIV regulatory protein Rev and stabilizes p53. Learn MoreStarting at: $239.00
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AM 114
AM 114 is an inhibitor of the chymotrypsin-like activity of the 20S proteasome that inhibits cell growth in human colon cancer HCT116 p53+/+ cells. Learn MoreStarting at: $99.00
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CID 2858522
CID 2858522 selectively inhibits protein kinase C (PKC)-induced activation of the NF-κB pathway and inhibits antigen receptor-stimulated NF-κB activation in chronic lymphocytic leukemia (CLL) B cells. Learn MoreStarting at: $109.00
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L-Arginine
L-Arginine is a precursor in the formation of nitric oxide. Learn MoreStarting at: $49.00
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Macbecin I
Macbecin I is an ensamycin antibiotic compound that inhibits Hsp90 activity by binding to the ATP-binding site. Learn MoreStarting at: $199.00
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cAMPS-Rp, triethylammonium salt
cAMPS-Rp, triethylammonium salt is a cell-permeable cAMP analog that acts as a competitive antagonist of cAMP-induced activation of PKA by interacting with cAMP binding sites on the regulatory subunits. Learn MoreStarting at: $99.00
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NAADP tetrasodium salt
NAADP tetrasodium salt initiates Ca2+ release via type 1 ryanodine receptor (RyR1) activation and also regulates Ca2+ release from intracellular stores distinct from the endoplasmic reticulum (ER). Learn MoreStarting at: $219.00
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STO-609 acetate
STO-609 acetate is a selective, cell-permeable inhibitor of Ca2+-calmodulin-dependent protein kinase kinase. The Ki values are 80 and 15 ng/ml for inhibition of CaM-KKα and CaM-KKβ respectively. Learn MoreStarting at: $69.00
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20(S)-Hydroxycholesterol
20(S)-Hydroxycholesterol is a allosteric activator of the Hedgehog signaling pathway Smoothened (Smo) oncoprotein that activates Hedgehog (Hh) signaling (EC50 ~ 3μM for induction of Hh reporter gene transcription in in NIH 3T3 cells). Learn More -
Dibutyryl-cAMP, sodium salt
LY 333531 hydrochloride is an isozyme-selective inhibitor of protein kinase C (PKC); competitively and reversibly inhibits PKCβI and PKCβII (IC50 values are 4.7 and 5.9 nM respectively). Exhibits selectivity for PKC over other ATP-dependent kinases, including protein kinase A, casein kinase and src). Learn MoreStarting at: $55.00
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Pyrrolidinedithiocarbamate ammonium
This inhibitor of nuclear factor κB (NF-κB) prevents the increase in NO-synthase mRNA by interleukin-1, without affecting the formation of NO-synthase mRNA produced by cAMP. Learn MoreStarting at: $65.00
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Jervine
Jervine is an inhibitor of Hedgehog signaling (IC50 = 500 - 700 nM), which binds directly to Smoothened (Smo), and inhibits the response of target tissues to Sonic hedgehog signaling, possibly via the sterol sensing domain of Patched. Learn MoreStarting at: $159.00
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17-DMAG hydrochloride
17-DMAG hydrochloride is a water-soluble analog of 17-AAG and geldanamycin, which binds the ATP binding site of Hsp90 and inhibits its chaperone activity, and displays more potent antitumor activity than 17-AAG (mean GI50 values are 53 and 123 nM for 17-DMAG and 17-AAG respectively). Learn MoreStarting at: $159.00
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JW 67
JW 67 is an inhibitor of canonical Wnt pathway signaling (IC50 = 1.17 μM); targets the β-catenin destruction complex (GSK-3β/AXIN/APC) to induce β-catenin degradation. Learn MoreStarting at: $109.00
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Eeyarestatin I
Eeyarestatin I is a potent inhibitor of endoplasmic reticulum associated protein degradation (ERAD), which specifically targets the p97-associated deubiquinating process (PAD) and inhibits ataxin-3 (atx3)-dependent deubiquitination. Learn MoreStarting at: $149.00
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Gue 1654
Gue 1654 is an oxoeicosanoid receptor 1 (OXE-R) modulator, which selectively inhibits Gβγ but not Gαi signaling upon activation of the Gαi-βγ heterotrimer by OXE-R. Learn MoreStarting at: $90.00
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AY 9944 dihydrochloride
AY 9944 dihydrochloride is an inhibitor of hedgehog (Hh) signaling, possibly via several mechanisms, which inhibits Δ7-dehydrocholesterol reductase (IC50 = 13 nM), thus reduces cholesterol biosynthesis, and also inhibits cholesterol esterification. Learn MoreStarting at: $119.00
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DMPO
Water soluble nitric oxide spin trap; allows the measurement of oxygen-centered free radicals in biological systems at room temperature using electron spin resonance (ESR). Learn MoreStarting at: $55.00
