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Search results for 'inhibitor'
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BTZO 1
BTZO 1 is a macrophage migration inhibitory factor (MIF) binder (Kd = 68.6 nM), which activates antioxidant response element (ARE)-mediated gene expression and suppresses oxidative stress-induced cardiomyocyte apoptosis in vitro. Learn MoreStarting at: $95.00
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SD 1008
SD 1008 is a JAK2/STAT3 signaling pathway inhibitor, which inhibits activation of STAT3, JAK2 and Src. Learn MoreStarting at: $109.00
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(-)-Xestospongin C
(-)-Xestospongin C is a highly potent, reversible and cell-permeable inhibitor of IP3-mediated Ca2+ release with an IC50 value of 358 nM. Learn MoreStarting at: $149.00
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CCG 50014
CCG 50014 is a potent and selective inhibitor of regulator of G-protein signaling 4 (RGS4) protein that exhibits >20-fold selectivity for RGS4 over other RGS proteins. Learn MoreStarting at: $125.00
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MDL 28170
MDL 28170 is a potent, selective inhibitor of calpain and cathepsin B that rapidly penetrates the blood-brain barrier following systemic administration and displays neuroprotective effects in vivo. Learn MoreStarting at: $65.00
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Leptomycin B
Leptomycin B, an antifungal antibiotic, is an inhibitor of the nuclear export of proteins that inhibits the nuclear export of the HIV regulatory protein Rev and stabilizes p53. Learn MoreStarting at: $239.00
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AM 114
AM 114 is an inhibitor of the chymotrypsin-like activity of the 20S proteasome that inhibits cell growth in human colon cancer HCT116 p53+/+ cells. Learn MoreStarting at: $99.00
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SecinH3
SecinH3 is a sec7-specific GEF inhibitor that inhibits insulin signaling via inhibition of insulin receptor substrate protein (IRS) phosphorylation. Learn MoreStarting at: $169.00
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ICG 001
ICG 001 is an inhibitor of TCF/β-catenin-mediated transcription that inhibits β-catenin/CBP interaction. Learn MoreStarting at: $99.00
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ML 130
ML 130 is a potent and selective inhibitor of NOD1 that inhibits NOD1-induced NF-κB activation in HEK293 cells with no cytotoxicity. Learn MoreStarting at: $119.00
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CID 5951923
CID 5951923 is an inhibitor of Krüppel-like factor 5 (KLF5) transcription factor. Learn MoreStarting at: $149.00
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iCRT 14
iCRT 14 is a potent inhibitor of β-catenin-responsive transcription (CRT) with IC50 of 40.3 nM in assays of Wnt pathway activity. Learn MoreStarting at: $139.00
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Ro 106-9920
Ro 106-9920 is a small molecule inhibitor of NF-κB-dependent expression of TNF-α, interleukin-1β, and interleukin-6. Learn MoreStarting at: $109.00
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HPI 1
HPI 1, a Hedgehog (Hh) signaling inhibitor, inhibits Sonic hedgehog (Shh)-, SAG- and Gli-induced Hh pathway activation in Shh-LIGHT2 cells with IC50 values of 1.5, 1.5, 4 and 6 μM for Shh-, SAG-, Gli2- and Gli1-induced activation. Learn MoreStarting at: $129.00
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STO-609 acetate
STO-609 acetate is a selective, cell-permeable inhibitor of Ca2+-calmodulin-dependent protein kinase kinase. The Ki values are 80 and 15 ng/ml for inhibition of CaM-KKα and CaM-KKβ respectively. Learn MoreStarting at: $69.00
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Dibutyryl-cAMP, sodium salt
LY 333531 hydrochloride is an isozyme-selective inhibitor of protein kinase C (PKC); competitively and reversibly inhibits PKCβI and PKCβII (IC50 values are 4.7 and 5.9 nM respectively). Exhibits selectivity for PKC over other ATP-dependent kinases, including protein kinase A, casein kinase and src). Learn MoreStarting at: $55.00
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Pyrrolidinedithiocarbamate ammonium
This inhibitor of nuclear factor κB (NF-κB) prevents the increase in NO-synthase mRNA by interleukin-1, without affecting the formation of NO-synthase mRNA produced by cAMP. Learn MoreStarting at: $65.00
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Jervine
Jervine is an inhibitor of Hedgehog signaling (IC50 = 500 - 700 nM), which binds directly to Smoothened (Smo), and inhibits the response of target tissues to Sonic hedgehog signaling, possibly via the sterol sensing domain of Patched. Learn MoreStarting at: $159.00
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Exo1
Exo1 is a reversible inhibitor of vesicular trafficking between endoplasmic reticulum and Golgi apparatus. Learn MoreStarting at: $95.00
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JW 67
JW 67 is an inhibitor of canonical Wnt pathway signaling (IC50 = 1.17 μM); targets the β-catenin destruction complex (GSK-3β/AXIN/APC) to induce β-catenin degradation. Learn MoreStarting at: $109.00
