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Search results for 'inhibit'
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BTZO 1
BTZO 1 is a macrophage migration inhibitory factor (MIF) binder (Kd = 68.6 nM), which activates antioxidant response element (ARE)-mediated gene expression and suppresses oxidative stress-induced cardiomyocyte apoptosis in vitro. Learn MoreStarting at: $95.00
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SD 1008
SD 1008 is a JAK2/STAT3 signaling pathway inhibitor, which inhibits activation of STAT3, JAK2 and Src. Learn MoreStarting at: $109.00
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(-)-Xestospongin C
(-)-Xestospongin C is a highly potent, reversible and cell-permeable inhibitor of IP3-mediated Ca2+ release with an IC50 value of 358 nM. Learn MoreStarting at: $149.00
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W-13 hydrochloride
W-13 hydrochloride is a calmodulin antagonist that inhibits calmodulin activated PDE activity with an IC50 of 68 μM. Learn MoreStarting at: $99.00
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CCG 50014
CCG 50014 is a potent and selective inhibitor of regulator of G-protein signaling 4 (RGS4) protein that exhibits >20-fold selectivity for RGS4 over other RGS proteins. Learn MoreStarting at: $125.00
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MDL 28170
MDL 28170 is a potent, selective inhibitor of calpain and cathepsin B that rapidly penetrates the blood-brain barrier following systemic administration and displays neuroprotective effects in vivo. Learn MoreStarting at: $65.00
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Leptomycin B
Leptomycin B, an antifungal antibiotic, is an inhibitor of the nuclear export of proteins that inhibits the nuclear export of the HIV regulatory protein Rev and stabilizes p53. Learn MoreStarting at: $239.00
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AM 114
AM 114 is an inhibitor of the chymotrypsin-like activity of the 20S proteasome that inhibits cell growth in human colon cancer HCT116 p53+/+ cells. Learn MoreStarting at: $99.00
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SecinH3
SecinH3 is a sec7-specific GEF inhibitor that inhibits insulin signaling via inhibition of insulin receptor substrate protein (IRS) phosphorylation. Learn MoreStarting at: $169.00
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ICG 001
ICG 001 is an inhibitor of TCF/β-catenin-mediated transcription that inhibits β-catenin/CBP interaction. Learn MoreStarting at: $99.00
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ML 130
ML 130 is a potent and selective inhibitor of NOD1 that inhibits NOD1-induced NF-κB activation in HEK293 cells with no cytotoxicity. Learn MoreStarting at: $119.00
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A-7 hydrochloride
A-7 hydrochloride is a potent calmodulin antagonist that inhibits calmodulin-activated PDE activity with an IC50 of 3 μM. Learn MoreStarting at: $89.00
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CID 2858522
CID 2858522 selectively inhibits protein kinase C (PKC)-induced activation of the NF-κB pathway and inhibits antigen receptor-stimulated NF-κB activation in chronic lymphocytic leukemia (CLL) B cells. Learn MoreStarting at: $109.00
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CID 5951923
CID 5951923 is an inhibitor of Krüppel-like factor 5 (KLF5) transcription factor. Learn MoreStarting at: $149.00
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Carbenoxolone disodium
Carbenoxolone disodium is a glucocorticoid that inhibits 11β-hydroxysteroid dehydrogenase (11-HSD) and blocks gap junction communication. Learn MoreStarting at: $65.00
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Macbecin I
Macbecin I is an ensamycin antibiotic compound that inhibits Hsp90 activity by binding to the ATP-binding site. Learn MoreStarting at: $199.00
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SCH 202676 hydrobromide
SCH 202676 hydrobromide is a sulphydryl-reactive compound that inhibits agonist and antagonist binding to G-protein-coupled receptors that inhibits a variety of GPCRs including adenosine, opioid, muscarinic, adrenergic and dopaminergic receptors IC50 values of 0.1-1.8 μM. Learn MoreStarting at: $115.00
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W-9 hydrochloride
W-9 hydrochloride is a Calmodulin antagonist that inhibits calmodulin-activated PDE activity with an IC50 of 72 μM. Learn MoreStarting at: $109.00
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iCRT 14
iCRT 14 is a potent inhibitor of β-catenin-responsive transcription (CRT) with IC50 of 40.3 nM in assays of Wnt pathway activity. Learn MoreStarting at: $139.00
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Ro 106-9920
Ro 106-9920 is a small molecule inhibitor of NF-κB-dependent expression of TNF-α, interleukin-1β, and interleukin-6. Learn MoreStarting at: $109.00
