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Search results for 'as'
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(-)-Xestospongin C
(-)-Xestospongin C is a highly potent, reversible and cell-permeable inhibitor of IP3-mediated Ca2+ release with an IC50 value of 358 nM. Learn MoreStarting at: $149.00
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AM 114
AM 114 is an inhibitor of the chymotrypsin-like activity of the 20S proteasome that inhibits cell growth in human colon cancer HCT116 p53+/+ cells. Learn MoreStarting at: $99.00
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8-Bromo-cAMP (sodium salt)
8-Bromo-cAMP(sodium salt) is a cell-permeable cAMP analog and activator of protein kinase A. Learn MoreStarting at: $59.00
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CID 2858522
CID 2858522 selectively inhibits protein kinase C (PKC)-induced activation of the NF-κB pathway and inhibits antigen receptor-stimulated NF-κB activation in chronic lymphocytic leukemia (CLL) B cells. Learn MoreStarting at: $109.00
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Carbenoxolone disodium
Carbenoxolone disodium is a glucocorticoid that inhibits 11β-hydroxysteroid dehydrogenase (11-HSD) and blocks gap junction communication. Learn MoreStarting at: $65.00
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cAMPS-Rp, triethylammonium salt
cAMPS-Rp, triethylammonium salt is a cell-permeable cAMP analog that acts as a competitive antagonist of cAMP-induced activation of PKA by interacting with cAMP binding sites on the regulatory subunits. Learn MoreStarting at: $99.00
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cAMPS-Sp, triethylammonium salt
cAMPS-Sp, triethylammonium salt is a cell-permeable cAMP analog that activates cAMP receptor proteins such as PKA and cAMP-regulated guanine nucleotide exchange factor. Learn MoreStarting at: $99.00
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iCRT 14
iCRT 14 is a potent inhibitor of β-catenin-responsive transcription (CRT) with IC50 of 40.3 nM in assays of Wnt pathway activity. Learn MoreStarting at: $139.00
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W-7 hydrochloride
W-7 hydrochloride is a calmodulin antagonist that inhibits Ca2+-calmodulin-dependent phosphodiesterase and myosin light chain kinase. Learn MoreStarting at: $99.00
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Cardionogen 1
Cardionogen 1, a wnt signaling modulator, potently inhibits Wnt/β-catenin-dependent transcription in murine ES cells and zebrafish embryos and Enlarges heart size via cardiomyocyte hyperplasia; induces ES cell cardiac differentiation. Learn MoreStarting at: $139.00
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Calmidazolium chloride
Calmidazolium chloride is a calmodulin antagonist. Inhibits calmodulin-dependent phosphodiesterase and Ca2+-transporting ATPase with IC50 values of 0.15 and 0.35 μM respectively. Learn MoreStarting at: $99.00
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NAADP tetrasodium salt
NAADP tetrasodium salt initiates Ca2+ release via type 1 ryanodine receptor (RyR1) activation and also regulates Ca2+ release from intracellular stores distinct from the endoplasmic reticulum (ER). Learn MoreStarting at: $219.00
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STO-609 acetate
STO-609 acetate is a selective, cell-permeable inhibitor of Ca2+-calmodulin-dependent protein kinase kinase. The Ki values are 80 and 15 ng/ml for inhibition of CaM-KKα and CaM-KKβ respectively. Learn MoreStarting at: $69.00
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Dibutyryl-cAMP, sodium salt
LY 333531 hydrochloride is an isozyme-selective inhibitor of protein kinase C (PKC); competitively and reversibly inhibits PKCβI and PKCβII (IC50 values are 4.7 and 5.9 nM respectively). Exhibits selectivity for PKC over other ATP-dependent kinases, including protein kinase A, casein kinase and src). Learn MoreStarting at: $55.00
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8-Bromo-cGMP, sodium salt
Membrane permeable cGMP analog that activates protein kinase G (PKG). 4.3-fold more potent than cGMP in activating PKG1α and promotes relaxation of tracheal and vascular smooth muscle tissue in vitro. Learn MoreStarting at: $55.00
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Pyrrolidinedithiocarbamate ammonium
This inhibitor of nuclear factor κB (NF-κB) prevents the increase in NO-synthase mRNA by interleukin-1, without affecting the formation of NO-synthase mRNA produced by cAMP. Learn MoreStarting at: $65.00
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Exo1
Exo1 is a reversible inhibitor of vesicular trafficking between endoplasmic reticulum and Golgi apparatus. Learn MoreStarting at: $95.00
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ODQ
ODQ is a potent and selective inhibitor of NO-sensitive guanylyl cyclase. Learn MoreStarting at: $79.00
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Eeyarestatin I
Eeyarestatin I is a potent inhibitor of endoplasmic reticulum associated protein degradation (ERAD), which specifically targets the p97-associated deubiquinating process (PAD) and inhibits ataxin-3 (atx3)-dependent deubiquitination. Learn MoreStarting at: $149.00
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4-IPP
4-IPP is an inhibitor of macrophage migration inhibitory factor (MIF), which acts as a suicide substrate to inactivate MIF catalytic and biological functions; inhibits MIF-associated liver enzyme activity in vivo. Learn MoreStarting at: $105.00
