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Search results for 'AG 490'
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BTZO 1
BTZO 1 is a macrophage migration inhibitory factor (MIF) binder (Kd = 68.6 nM), which activates antioxidant response element (ARE)-mediated gene expression and suppresses oxidative stress-induced cardiomyocyte apoptosis in vitro. Learn MoreStarting at: $95.00
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BI 6015
BI 6015 is a hepatocyte nuclear factor 4α (HNF4α) antagonist that exhibits cytotoxic activity in a range of tumor cell lines, including human hepatocellular carcinoma. Learn MoreStarting at: $129.00
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W-13 hydrochloride
W-13 hydrochloride is a calmodulin antagonist that inhibits calmodulin activated PDE activity with an IC50 of 68 μM. Learn MoreStarting at: $99.00
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A-7 hydrochloride
A-7 hydrochloride is a potent calmodulin antagonist that inhibits calmodulin-activated PDE activity with an IC50 of 3 μM. Learn MoreStarting at: $89.00
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cAMPS-Rp, triethylammonium salt
cAMPS-Rp, triethylammonium salt is a cell-permeable cAMP analog that acts as a competitive antagonist of cAMP-induced activation of PKA by interacting with cAMP binding sites on the regulatory subunits. Learn MoreStarting at: $99.00
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SCH 202676 hydrobromide
SCH 202676 hydrobromide is a sulphydryl-reactive compound that inhibits agonist and antagonist binding to G-protein-coupled receptors that inhibits a variety of GPCRs including adenosine, opioid, muscarinic, adrenergic and dopaminergic receptors IC50 values of 0.1-1.8 μM. Learn MoreStarting at: $115.00
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W-9 hydrochloride
W-9 hydrochloride is a Calmodulin antagonist that inhibits calmodulin-activated PDE activity with an IC50 of 72 μM. Learn MoreStarting at: $109.00
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W-7 hydrochloride
W-7 hydrochloride is a calmodulin antagonist that inhibits Ca2+-calmodulin-dependent phosphodiesterase and myosin light chain kinase. Learn MoreStarting at: $99.00
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W-5 hydrochloride
W-5 hydrochloride is a Calmodulin antagonist that inhibits Ca2+-calmodulin dependent PDE with an IC50 of 240 μM. Learn MoreStarting at: $99.00
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HPI 1
HPI 1, a Hedgehog (Hh) signaling inhibitor, inhibits Sonic hedgehog (Shh)-, SAG- and Gli-induced Hh pathway activation in Shh-LIGHT2 cells with IC50 values of 1.5, 1.5, 4 and 6 μM for Shh-, SAG-, Gli2- and Gli1-induced activation. Learn MoreStarting at: $129.00
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SNOG
SNOG is a carrier of NO, relaxing smooth muscle and inhibiting platelet aggregation. Learn MoreStarting at: $59.00
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Calmidazolium chloride
Calmidazolium chloride is a calmodulin antagonist. Inhibits calmodulin-dependent phosphodiesterase and Ca2+-transporting ATPase with IC50 values of 0.15 and 0.35 μM respectively. Learn MoreStarting at: $99.00
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Pirfenidone
Pirfenidone is a antifibrotic agent, effective in models of pulmonary and lung fibrosis that regulates cytokine levels following oral administration in vivo. Learn MoreStarting at: $89.00
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SIN-1 chloride
ZK 200775 is a competitive AMPA/kainate antagonist. Learn MoreStarting at: $98.00
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17-DMAG hydrochloride
17-DMAG hydrochloride is a water-soluble analog of 17-AAG and geldanamycin, which binds the ATP binding site of Hsp90 and inhibits its chaperone activity, and displays more potent antitumor activity than 17-AAG (mean GI50 values are 53 and 123 nM for 17-DMAG and 17-AAG respectively). Learn MoreStarting at: $159.00
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NDT 9513727
NDT 9513727 is a potent C5a receptor (C5aR) competitive antagonist (IC50 = 11.6 nM); selective for human C5aR (IC50 values for rat and mouse C5aR are > 10 μM), which exhibits inverse agonist pharmacokinetics. Learn MoreStarting at: $189.00
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4-IPP
4-IPP is an inhibitor of macrophage migration inhibitory factor (MIF), which acts as a suicide substrate to inactivate MIF catalytic and biological functions; inhibits MIF-associated liver enzyme activity in vivo. Learn MoreStarting at: $105.00
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NPC 15199
NPC 15199 is an anti-inflammatory agent; increases intracellular Ca2+ levels. Learn MoreStarting at: $59.00
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SANT-2
SANT-2 is an inhibitor of Sonic hedgehog (Shh) signaling; antagonizes smoothened receptor activity (KD = 12 nM), which displays allosteric binding characteristics similar to SANT-1. Displaces smo-[3H]SAG-1.3 and -[3H]Cyclopamine binding (Ki values are 7.8 nM and 8.4 nM respectively). Learn MoreStarting at: $139.00
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Ciliobrevin A
Ciliobrevin A is a hedgehog (Hh) pathway antagonist which blocks Sonic hedgehog (Shh)-induced Hh pathway activation (IC50 = 7 μM) downstream of Smo. Learn MoreStarting at: $119.00
