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GPP 78 hydrochloride
GPP 78 hydrochloride is an inhibitor of nicotinamide phosphoribosyltransferase (NMPRTase); potently depletes NAD levels and exhibits cytotoxicity in vitro (IC50 values are 3.0 and 3.8 nM respectively). Learn MoreStarting at: $169.00
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Galloflavin
Galloflavin is an inhibitor of human lactate dehydrogenase (LDH) (Ki values are 5.46 and 15.1 μM for LDH-A and LDH-B, respectively, in competition with pyruvate), which inhibits lactate production and decreases ATP synthesis in PLD/PRF/5 cells. Learn MoreStarting at: $109.00
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UNC 1215
UNC 1215 is a potent inhibitor of L3MBTL3 methyllysine (Kme) reader domain (IC50 = 40 nM; Kd = 120 nM), which displays >100-fold selectivity over a panel of histone methyltransferases, kinases, ion channels and 7-TM receptors. Learn MoreStarting at: $149.00
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SGC 0946
SGC 0946 is a potent DOT1L methyltransferase inhibitor (KD = 0.06 nM, IC50 = 0.3 nM in a radioactive assay) which blocks H3K79 methylation in A431 cells and MCF10A cells (IC50 values are 2.65 and 8.8 nM respectively). Learn MoreStarting at: $199.00
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TCS HDAC6 20b
TCS HDAC6 20b is a selective inhibitor of histone deacetylase 6 (HDAC6) that inhibits HCT116 growth in combination with taxol. Learn MoreStarting at: $149.00
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KD 5170
KD 5170 is a histone deacetylase (HDAC) inhibitor that exhibits broad spectrum inhibition of HDAC classes I and II in assays using purified recombinant human isoforms. Learn MoreStarting at: $139.00
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TC-H 106
TC-H 106 is a class I histone deacetylase (HDAC) inhibitor with IC50 values of 150, 370, 760 and 5000 nM for HDAC1, HDAC3, HDAC2 and HDAC8 respectively. Learn MoreStarting at: $125.00
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NCH 51
NCH 51 is a histone deacetylase (HDAC) inhibitor that inhibits growth of various cancer cells in vitro. Learn MoreStarting at: $115.00
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Okadaic acid
Okadaic acid is a potent inhibitor of protein phosphatase 1 with an IC50 value of 3 nM) and protein phosphatase 2A with an IC50 value of 0.2-1 nM. Learn MoreStarting at: $89.00
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ZM 39923 hydrochloride
ZM 39923 hydrochloride is a potent, selective inhibitor of Janus tyrosine kinase 3 (JAK3) with pIC50 values of 7.1, 5.6, 4.4, and < 5.0 for JAK3, EGFR, JAK1 and CDK4 respectively. Learn MoreStarting at: $119.00
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NSC 87877
NSC 87877 is a potent inhibitor of shp2 and shp1 protein tyrosine phosphatases (PTP). NSC 87877 blocks epidermal growth factor receptor-induced activation of Ras and ERK1/2 in HEK293 cells, stimulates store-operated calcium entry in response to thrombin in platelets, and increased acetylcholine receptor clustering in myotubes. Learn MoreStarting at: $95.00
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Sanguinarine chloride
Sanguinarine chloride is an inhibitor of protein phosphatase 2C (PP2C), selective over PP1, PP2A and PP2B in vitro. Learn MoreStarting at: $99.00
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TCS PIM-1 1
TCS PIM-1 1 is an ATP-competitive Pim-1 kinase inhibitor that displays selectivity over Pim-2 and MEK1/2 (IC50 values are 50, > 20000 and > 20000 nM for Pim-1, Pim-2 and MEK1/2 respectively). Learn MoreStarting at: $109.00
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PIM-1 Inhibitor 2
PIM-1 Inhibitor 2 is a potent Pim-1 kinase inhibitor (Ki = 91 nM). Learn MoreStarting at: $125.00
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BVT 948
BVT 948 is a non-competitive, cell-permeable inhibitor of protein tyrosine phosphatases (PTPs) (IC50 = 0.09 - 1.7 μM); displays irreversible inhibition through catalysis of the hydrogen peroxide-dependent oxidation of PTP. Learn MoreStarting at: $95.00
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NSC 3852
NSC 3852 is a histone deacetylase inhibitor. Causes cell differentiation and antiproliferative activity in MCF-7 human breast cancer cells in vitro and displays antitumor activity in vivo. Learn MoreStarting at: $45.00
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Ceramide
Ceramide is a potent modulator of cell proliferation and differentiation, which activates protein phosphatase-1 (PP1) and -2A (PP2A), as well as ceramide-activated protein phosphatase (CAPP) in vitro. Learn MoreStarting at: $95.00
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M 344
Histone deacetylase inhibitor (IC50 = 100 nM) which induces terminal cell differentiation and causes an increase in hyperacetylated histone H4. Learn MoreStarting at: $55.00
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TCS 401
TCS 401 is a selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B) (Ki values are 0.29, 59, 560, 1100, > 2000, > 2000 and > 2000 μM for PTP1B, CD45 D1D2, PTPβ, PTPε D1, SHP-1, PTPα D1 and LAR D1D2 respectively). Learn MoreStarting at: $139.00
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1,2,3,4,5,6-Hexabromocyclohexane
1,2,3,4,5,6-Hexabromocyclohexane potently and directly inhibits JAK2 tyrosine kinase autophosphorylation, specifically inhibiting ligand-dependent JAK2 activation. Learn MoreStarting at: $75.00
