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Search results for 'PR 171'
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GPP 78 hydrochloride
GPP 78 hydrochloride is an inhibitor of nicotinamide phosphoribosyltransferase (NMPRTase); potently depletes NAD levels and exhibits cytotoxicity in vitro (IC50 values are 3.0 and 3.8 nM respectively). Learn MoreStarting at: $169.00
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Galloflavin
Galloflavin is an inhibitor of human lactate dehydrogenase (LDH) (Ki values are 5.46 and 15.1 μM for LDH-A and LDH-B, respectively, in competition with pyruvate), which inhibits lactate production and decreases ATP synthesis in PLD/PRF/5 cells. Learn MoreStarting at: $109.00
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Okadaic acid
Okadaic acid is a potent inhibitor of protein phosphatase 1 with an IC50 value of 3 nM) and protein phosphatase 2A with an IC50 value of 0.2-1 nM. Learn MoreStarting at: $89.00
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NSC 87877
NSC 87877 is a potent inhibitor of shp2 and shp1 protein tyrosine phosphatases (PTP). NSC 87877 blocks epidermal growth factor receptor-induced activation of Ras and ERK1/2 in HEK293 cells, stimulates store-operated calcium entry in response to thrombin in platelets, and increased acetylcholine receptor clustering in myotubes. Learn MoreStarting at: $95.00
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Sanguinarine chloride
Sanguinarine chloride is an inhibitor of protein phosphatase 2C (PP2C), selective over PP1, PP2A and PP2B in vitro. Learn MoreStarting at: $99.00
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BVT 948
BVT 948 is a non-competitive, cell-permeable inhibitor of protein tyrosine phosphatases (PTPs) (IC50 = 0.09 - 1.7 μM); displays irreversible inhibition through catalysis of the hydrogen peroxide-dependent oxidation of PTP. Learn MoreStarting at: $95.00
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NSC 3852
NSC 3852 is a histone deacetylase inhibitor. Causes cell differentiation and antiproliferative activity in MCF-7 human breast cancer cells in vitro and displays antitumor activity in vivo. Learn MoreStarting at: $45.00
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Ceramide
Ceramide is a potent modulator of cell proliferation and differentiation, which activates protein phosphatase-1 (PP1) and -2A (PP2A), as well as ceramide-activated protein phosphatase (CAPP) in vitro. Learn MoreStarting at: $95.00
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TCS 401
TCS 401 is a selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B) (Ki values are 0.29, 59, 560, 1100, > 2000, > 2000 and > 2000 μM for PTP1B, CD45 D1D2, PTPβ, PTPε D1, SHP-1, PTPα D1 and LAR D1D2 respectively). Learn MoreStarting at: $139.00
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Sodium 4-Phenylbutyrate
Sodium 4-Phenylbutyrate is a histone deacetylase inhibitor that displays anticancer activity. Learn MoreStarting at: $65.00
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Alexidine dihydrochloride
Alexidine dihydrochloride is a selective inhibitor of protein tyrosine phosphatases localized to mitochondrion 1 (PTPMT1) (IC50 = 1.08 μM in vitro). Learn MoreStarting at: $70.00
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UNC 926 hydrochloride
UNC 926 hydrochloride is a methyl-lysine (Kme) reader domain inhibitor; binds to the MBT domain of the L3MBTL1 protein (Kd = 3.9 μM), which selectively inhibits the L3MBTL13XMBT-H4K20me1 interaction in a peptide pull down assay. Learn MoreStarting at: $110.00
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ZM 449829
Potent is a selective inhibitor of Janus tyrosine kinase 3 (JAK3), which binds competitively to the JAK3 ATP site. And inhibits STAT-5 phosphorylation and T-cell proliferation. Learn MoreStarting at: $89.00
